Automatic Ampoule Vial Washing Machine

Q: What is an Automatic Ampoule Vial Washing Machine and what does it clean?

The Automatic Ampoule Vial Washing Machine is a high-speed, rotary, cGMP-compliant washer designed for thorough internal and external cleaning of glass ampoules and vials. It uses a specialized gripper system that holds containers by the neck, inverts them for effective washing, and re-inverts them before discharge. The machine ensures removal of dust, particles, and contaminants, making it ideal for preparing sterile containers for injectable, biotech, veterinary, and cosmetic filling lines. It is available in two models: AVRW-120 and AVRW-240.

Q: What is the production capacity and size range of the Automatic Ampoule Vial Washing Machine?

AVRW-120 : Up to 100 ampoules/vials per minute AVRW-240 : Up to 200 ampoules/vials per minute (High Speed model) It handles 1ml to 10ml ampoules (diameter 9mm to 21.5mm, height 60mm to 140mm) and is also suitable for vials in the same range (with change parts). The washing sequence and speed are fully adjustable as per customer requirements.

Q: What utilities are required and what optional features are available?

Utilities Required: Power: 4 H.P. (AVRW-120) or 5.5 H.P. (AVRW-240), 440V, 3 Phase, 50 Hz Compressed Air: 20 CFM Water: 200–500 liters/hour (depending on size and sequence) Key Optional Features: Separate pumping station with 3 pumps and 3 × 25L tanks Recirculation and siliconization system No-vial-no-wash system (saves water & air) PLC with HMI, safety cabinet with interlock doors Automatic container counter and digital speed display

Q: Is Automatic Ampoule Vial Washing Machine cGMP, MHRA, FDA and WHO-GMP Compliant?

Yes — Adinath International Automatic Ampoule Vial Washing Machine complies to cGMP, MHRA, FDA and WHO-GMP standards, with optional CE marked equipments and 21 CFR Part 11 software compliance for the HMI/PLC. Machine contact parts having Stainless Steel 316L grade materials with validation documents having IQ, OQ, DQ validation protocols as optional. Organization is ISO 9001:2015 certified.

Q: Does Adinath International provide Automatic Ampoule Vial Washing Machine internationally?

Yes, Adinath International Automatic Ampoule Vial Washing Machine export this machine to more than 48 countries of this world including America, Europe, Asia, Middle East, Africa, CIS and Australia sub continents. Please visit our clientele page for complete list of our customers worldwide. Located at Ahmedabad, India having world class infrastructure .

Description

In the highly regulated pharmaceutical industry, maintaining impeccable cleanliness and sterility is paramount, especially for injectable products. A Automatic Ampoule Vial Washing Machine stands out as a reliable, semi-automatic, compact, and versatile piece of pharmaceutical equipment specifically designed to clean glass ampoules and vials effectively. This advanced ampoule washer ensures full compliance with current Good Manufacturing Practices (cGMP) standards, making it an essential asset for injectable manufacturing facilities worldwide.

Also known as a multi-jet ampoule washer or vial washing machine, this equipment uses high-pressure multijet technology to deliver powerful, targeted sprays of water and air inside and outside the containers. It thoroughly removes dust, particles, residues, and contaminants from glass ampoules and vials, preparing them for filling, sealing, and sterilization processes.

The machine is particularly popular in small to medium-scale injectable manufacturing units due to its user-friendly design and flexibility. With interchangeable change parts, it efficiently handles a wide range of sizes: ampoules from 1ml to 20ml and glass vials from 2ml to 100ml. This adaptability eliminates the need for multiple dedicated machines, saving space and investment costs.

Salient Features of Ampoule Vial Washing Machine

Fully cGMP-compliant model.
Production capacity of up to 200 ampoules per minute.
All parts in contact with the internal surface of the container and the wash media are manufactured from AISI 316L stainless steel.
Non-contact parts are constructed from engineering plastics and AISI 304 stainless steel.
Optionally supplied with 3 pumps and 3 tanks of 25 liters each.
Provides three water washes and three air washes.
Offers complete user flexibility in the washing cycle.
Equipped with 18 jets serving 6 internal washing zones.
Features 15 gripper cassettes, each fitted with 2 grippers.
Suitable for ampoules ranging from 1 ml to 10 ml.

Washing sequence can be customized according to customer requirements.
All surface finishes, welding joints, and selected components are processed and treated in accordance with cGMP standards.
Each washing zone has an independent circuit to prevent cross-contamination.
Automatic infeed and outfeed of containers.
Optionally equipped with a PLC system and password-protected printing facility.
Container unit counter with display on the control panel.
Can operate as a standalone machine or as part of an in-line system.
Digital speed indicator showing current output.
IQ/OQ/DQ validation documentation can be provided.
Programming and software validation in accordance with 21 CFR Part 11 available on request.

Working Principle of Automatic Ampoule Vial Washing Machine

Ampoules are fed from the infeed tray onto an infeed feed worm and then transferred to the infeed starwheel.

Grippers pick up each ampoule from the infeed starwheel, invert it to the neck-down position over the washing needles, and advance it together with the needle bar during the washing cycle.

Traveling in the neck-down position above the washing needles ensures maximum washing time once the needles enter the ampoule neck.

The machine is equipped with six distinct washing stations, each fitted with six needles, for optimum cleaning; the washing sequence can be adjusted as required.

An external wash station is also provided for thorough external cleaning of the ampoules.

On completion of the washing cycle, the ampoules are inverted back to the neck-up position and transferred to the output starwheel.

Washed ampoules received from the output starwheel can be collected on the output tray or transferred directly into a tunnel.

An optional separate pumping station supplies the precise volume of water at the required pressure. In the absence of a separate pumping station, a re-circulation and siliconization system can be provided on request.

INTERNAL CLEANING The AVRW is equipped with six internal cleaning stations. Each station has six cleaning needles, giving a total of 36 needles. Every cleaning station is supplied through a dedicated pipe connected to the cleaning-media distribution area. This design reduces the risk of particle generation, simplifies maintenance and cleaning, and saves time.

EXTERNAL CLEANING Three external cleaning stations are mounted in a fixed position above the ampoules. Each station can be easily adjusted for height, angle, and lateral position. Cleaning media is supplied to each station via a pipe connected to the cleaning-media distribution area.

CLEANING MEDIA PRINCIPLE WFI, purified water, and compressed-air cleaning stations are synchronized with ampoule movement by means of a reciprocating motion. The design ensures that these media are dispensed only while the needles are advancing. WFI consumption is further reduced by collecting used WFI in a re-circulating tank for subsequent use in the pre-washing station.

Technical Specification of Ampoule Vial Washing Machine

Model	AVRW 120	AVRW 240
Production Output	Up to 100 per minute	Up to 200 per minute
Ampoule Diameter	9mm to 21.5mm	9mm to 21.5mm
Ampoule Height	60mm to 140mm	60mm to 140mm
Power Load	4 H.P.	5.5 H.P.
Power Voltage	440 Volts, 3 Phase 50 Hertz, 4 wire system	440 Volts, 3 Phase 50 Hertz, 4 wire system.
Optional Accessories	Programmable Logic Control (System) with HMI Safety Cabinet with doors	Programmable Logic Control (System) with HMI Safety Cabinet with doors
Utility	Air – 20 CFM Water – 200 to 500 liters per hour depend upon ampoule size.	Air – 20 CFM Water – 200 to 500 liters per hour depend upon ampoule size.
Water Tank & Pump	3 nos. each with 25 liters Capacity & Centrifugal pump	3 nos. each with 25 liters Capacity & Centrifugal pump
Overall Dimension:	2050mm (L) X 2000mm (W) X 1210mm (H) approx.	2450mm (L) X 2000mm (W) X 1300mm (H) approx.
Net Weight	700 kgs. approx.	900 kgs. approx.
Gross Weight	1000 kgs. approx.	1300 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Washing Machine

Ampoule Vial Washing Machine

Automatic Ampoule Washer

Automatic Rotary Ampoule Washing Machine

Automatic External Ampoule Washing Machine

Injectable Glass Ampoule Washing Machine

Lab Scale Ampoule Washing Machine

Multijet Ampoule Washing Machine

Rotary Ampoule Washer

Applications of Ampoule Vial Washing Machine

Washing Cycle of Automatic Ampoule Vial Washing Machine

1^st wash	Recycled Water (WFI)
2^nd wash	Compressed Air
3^rd wash	DM Water
4^th wash	Compressed Air
5^th wash	Water for Injection (WFI)
6^th wash	Compressed Air

Advantages of Automatic Ampoule Vial Washing Machine

High-Speed Production with Consistent Quality

Superior Internal & External Cleaning with Multi-Station Jets

Minimal Contact Design – Reduced Contamination Risk

Full cGMP Compliance & Easy Regulatory Validation

Key Features of Automatic Ampoule Vial Washing Machine

Construction: Made of AISI 316L stainless steel for contact parts and AISI 304 or FDA-approved engineering plastics for non-contact parts, ensuring durability and hygiene.

Gripper System: A specialized gripper holds containers by the neck, inverts them for washing, and releases them in a vertical position post-washing, minimizing contamination.

Washing Process: Typically includes 3 water washes (e.g., recycled water, purified water, Water for Injection – WFI) and 3 air washes for internal and external cleaning. Washing sequences are customizable.

Capacity: Models like AVRW-120 (up to 100 ampoules/vials per minute) and AVRW-240 (up to 200 ampoules/vials per minute) cater to different production needs.

Operation: Fully automatic with PLC control, optional printing facilities, and safety features like automatic stop if the acrylic cover is lifted. No-vial-no-wash systems reduce water and air wastage.

Cleaning Efficiency: Uses pressurized jets via multiple washing stations (e.g., 6 stations with 6 needles each) for thorough internal and external cleaning. WFI consumption is optimized via recirculation tanks.

Flexibility: Handles various container sizes (1ml to 20ml ampoules, 2ml to 100ml vials) with change parts. External washing stations are adjustable for precise cleaning.

Compliance: Designed to meet cGMP, GAMP, and 21 CFR Part 11 standards, with IQ/OQ/DQ validation documentation available.

FAQ for Automatic Ampoule Vial Washing Machine

What is an Automatic Ampoule Vial Washing Machine and what does it clean?

The Automatic Ampoule Vial Washing Machine is a high-speed, rotary, cGMP-compliant washer designed for thorough internal and external cleaning of glass ampoules and vials. It uses a specialized gripper system that holds containers by the neck, inverts them for effective washing, and re-inverts them before discharge. The machine ensures removal of dust, particles, and contaminants, making it ideal for preparing sterile containers for injectable, biotech, veterinary, and cosmetic filling lines. It is available in two models: AVRW-120 and AVRW-240.

What is the production capacity and size range of the Automatic Ampoule Vial Washing Machine?

AVRW-120: Up to 100 ampoules/vials per minute
AVRW-240: Up to 200 ampoules/vials per minute (High Speed model)

It handles 1ml to 10ml ampoules (diameter 9mm to 21.5mm, height 60mm to 140mm) and is also suitable for vials in the same range (with change parts). The washing sequence and speed are fully adjustable as per customer requirements.

How does the washing process work in the Automatic Ampoule Vial Washing Machine?

Containers are fed via an infeed tray and starwheel. Grippers pick them up by the neck, invert them (neck-down), and pass them over 6 internal washing stations (with 18 jets total). The standard cycle includes 3 water washes + 3 air washes with independent circuits:

Recycled Water / WFI
Compressed Air
DM Water
Compressed Air
Water for Injection (WFI)
Compressed Air

External washing is provided through 3 adjustable stations. After washing, ampoules/vials are re-inverted upright and discharged. This ensures maximum cleaning efficiency with minimal media consumption and no cross-contamination.

What materials and regulatory standards does the machine comply with?

All contact parts (with containers and washing media) are made of AISI 316L Stainless Steel. Non-contact parts use AISI 304 Stainless Steel and engineering plastics. The machine is a complete cGMP model with smooth finishes and pharmaceutical-grade welding. It supports IQ/OQ/DQ documentation and optional 21 CFR Part 11 compliant PLC + HMI with password protection and printing facility, making it easy to validate for FDA, WHO, and other regulatory audits.

What utilities are required and what optional features are available?

Utilities Required:

Power: 4 H.P. (AVRW-120) or 5.5 H.P. (AVRW-240), 440V, 3 Phase, 50 Hz
Compressed Air: 20 CFM
Water: 200–500 liters/hour (depending on size and sequence)

Key Optional Features:

Separate pumping station with 3 pumps and 3 × 25L tanks
Recirculation and siliconization system
No-vial-no-wash system (saves water & air)
PLC with HMI, safety cabinet with interlock doors
Automatic container counter and digital speed display

Is Automatic Ampoule Vial Washing Machine cGMP, MHRA, FDA and WHO-GMP Compliant?

Yes — Adinath International Automatic Ampoule Vial Washing Machine complies to cGMP, MHRA, FDA and WHO-GMP standards, with optional CE marked equipments and 21 CFR Part 11 software compliance for the HMI/PLC. Machine contact parts having Stainless Steel 316L grade materials with validation documents having IQ, OQ, DQ validation protocols as optional. Organization is ISO 9001:2015 certified.

What is the lead time for Automatic Ampoule Vial Washing Machine?

Manufacturing lead time is generally 7 to 14 weeks from order confirmation. Further it takes 2 to 8 weeks for international shipping depending upon destination. Order can be expediate sooner or later as per specific buying requirements. Destination specific certifications like US FDA, EU, ANVISA, SFDA. CE can add 3 to 6 weeks additionally.

Does Adinath International provide Automatic Ampoule Vial Washing Machine internationally?

Yes, Adinath International Automatic Ampoule Vial Washing Machine export this machine to more than 48 countries of this world including America, Europe, Asia, Middle East, Africa, CIS and Australia sub continents. Please visit our clientele page for complete list of our customers worldwide. Located at Ahmedabad, India having world class infrastructure.

Does After Sales Support provided for Automatic Ampoule Vial Washing Machine?

Service of skilled engineers and technicians provided for technical support of supplied equipments. Installations, commissioning, training and IQ, OQ, DQ validations performed by qualified engineers. Remote support through video call, phone, email and other modes provided for international installations. Spare parts of Automatic Ampoule Vial Washing Machine stocked at our premises in Ahmedabad and shipped immediately after ordering. Standard 12 months manufacturing warranty included with supplied equipment.

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Automatic Ampoule Vial Washing Machine

Description

Salient Features of Ampoule Vial Washing Machine

Working Principle of Automatic Ampoule Vial Washing Machine

Technical Specification of Ampoule Vial Washing Machine

Types of Ampoule Washing Machine

Injectable Glass Ampoule Washing Machine

Lab Scale Ampoule Washing Machine

Applications of Ampoule Vial Washing Machine

Washing Cycle of Automatic Ampoule Vial Washing Machine

Advantages of Automatic Ampoule Vial Washing Machine

High-Speed Production with Consistent Quality

Superior Internal & External Cleaning with Multi-Station Jets

Minimal Contact Design – Reduced Contamination Risk

Full cGMP Compliance & Easy Regulatory Validation

Key Features of Automatic Ampoule Vial Washing Machine

FAQ for Automatic Ampoule Vial Washing Machine

Countries We Export to

Partner with Industry Experts

Countries We Export to

Partner with Industry Experts

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