20ml Ampoule Filling Machine

Q: Which ampoule sizes can the 20ml Ampoule Filling Machine handle, and how easy is changeover?

The machine is optimized for 20ml ampoules and supports: AFS-1 : 1ml to 30ml AFS-2, AFS-4 & AFS-8 : 1ml to 20ml It works with both open-mouth and closed-mouth ampoules (Type B, C, or D). Changeover between sizes is quick with minimum changeover parts and mostly tool-less adjustments, resulting in very low downtime. The “No Ampoule – No Filling” system prevents product wastage.

Description

20ml Ampoule Filling Machine is designed for high-precision filling and sealing of 20ml glass ampoules, commonly used in pharmaceutical, biotech, cosmetic, and chemical industries. These machines ensure accurate dosing of liquid or semi-liquid products, maintain sterility, and comply with cGMP standards. Below is a detailed description based on typical features of such machines:

Machines can be configured for specific needs, such as handling larger 25ml or 30ml ampoules or integrating with upstream (washing, sterilization) and downstream (labeling, inspection) equipment.

Options for single-head to multi-head (up to 16 heads) configurations to match production scale.

Production Volume: Choose the number of filling heads based on required output (e.g., single-head for small-scale, multi-head for high-speed production).

Ampoule Type: Ensure compatibility with open or closed 20ml ampoules.

Regulatory Compliance: Verify cGMP compliance and suitability for sterile environments.

Maintenance: Opt for models with easy cleaning and minimal changeover time.

This machine ensures compliance with cGMP standards for sterile injectable filling. If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Salient Features of 20ml Ampoule Filling Machine

Minimum change over time, little maintenance, easy cleaning.
Higher production output up to 12000 Ampoules per hour.
All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Minimum change over parts from 1ml to 10ml ampoule size.
Ampoule neck centering during gas flushing and filling operations.

Compact model as per cGMP standard.
Possibility of nitrogen gas flushing before, during and after filling.
Full accessibility allows easy maintenance.
Machine equipped with pre-warming station.
Flow Meters for regulating flames easily.
“No Ampoule – No Filling” system.

Working Principle of 20ml Ampoule Filling Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect one/two/four/eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. For detailed working process please explore Automatic Ampoule Filler Video in top right section of this page.

Loading: Sterilized 20ml ampoules are loaded onto an infeed hopper or tray, then transferred via a starwheel or cassette to a moving rack.

Pre-Gassing: Nitrogen purging to remove air and prevent contamination.

Filling: Precise liquid dosing using piston or peristaltic pumps, with neck centering for accuracy.

Post-Gassing: Additional nitrogen flushing to ensure product stability.

Pre-Heating and Sealing: Ampoules are pre-heated, then sealed using oxygen/LPG flames.

Collection: Filled and sealed ampoules are automatically collected on a tray or dead plate for further processing.

Technical Specification of 20ml Ampoule Filling Machine

Model	AFS-1	AFS-2	AFS-4	AFS-8
No. of Head	Single	Two	Four	Eight
Syringes	One	Double	Four	Eight
Ampoule Sizes	1 ml to 30 ml	1 ml to 30 ml	1 ml to 20 ml	1 ml to 20 ml
Filling Speed	Up to 25 ampoules/minute	Up to 50 ampoules/minute	Up to 100 ampoules/minute	Up to 200 ampoules/minute
Filling Precision	± 1%	± 1%	± 1%	± 1%
Filling Pump	Piston Pump	Piston Pump	Piston Pump	Piston Pump
Burner Gas	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)
Nitrogen Arrangement	Before & After Filling	Before & After Filling	Before & After Filling	Before & After Filling
Number of Fill Nozzles	One	Two	Four	Eight
Number of Nitrogen Nozzles	Two	Four	Eight	Sixteen
Number of Sealing Burners	Two	Four	Eight	Sixteen
Power Required	0.5 H.P.	1 H.P.	1 H.P.	2 H.P.
Power Voltage	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L
Overall Dimension	915mm (L) x 610mm (W) x 965mm (H) approx.	915mm (L) x 760mm (W) x 965mm (H) approx.	1200mm (L) x 1070mm (W) x 965mm (H) approx.	2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of 20ml Ampoule Filling Machine

High Precision and Filling Accuracy

Enhanced Sterility and Product Safety

High Production Efficiency and Speed

Versatility and Flexibility

Improved Operational Convenience

Regulatory and Quality Compliance

Key Features of 20ml Ampoule Filling Machine

Capacity and Compatibility:
- Suitable for filling 20ml glass ampoules (open or closed, Type B, C, or D).
- Can handle a range of ampoule sizes (typically 1ml to 30ml) with minimal changeover parts, making it versatile for various production needs.
- Filling capacity ranges from 0.5ml to 25ml in a single dose, with some models supporting up to 30ml.

Filling Mechanism:
- Utilizes advanced filling technologies such as volumetric piston pumps, peristaltic pumps, or servo-driven systems for precise dosing with accuracy up to ±0.5%.
- Features “no ampoule, no fill” systems to minimize product wastage.
- Nitrogen gas flushing (pre- and post-filling) to prevent contamination and ensure product stability.

Sealing Process:
- Equipped with pre-heating and sealing stations using combustible gases (oxygen and LPG/propane) for hermetic sealing.
- Ampoule neck centering during filling and sealing to accommodate variations in neck dimensions and thickness.
- Flow meters regulate flame intensity for consistent sealing.

Construction and Design:
- Built with stainless steel 316L for contact parts and 304 for non-contact parts, ensuring durability and compliance with cGMP standards.
- Monoblock design integrates loading, filling, sealing, and collection on a single platform for efficiency.
- Slant travel mechanism to handle variations in ampoule dimensions and ensure smooth operation.
- Compact structure with large openings for easy cleaning and maintenance.

Production Speed:
- Capable of filling 15 to 250 ampoules per minute, depending on the model and number of filling heads (single, two, four, six, or eight).
- High-speed models can achieve up to 36,000 ampoules per hour.

Automation and Control:
- PLC-based control systems with touch-screen HMI for real-time monitoring and parameter adjustments (e.g., fill volume, conveyor speed, flame intensity).
- Optional high-precision inspection cameras and sensors to ensure quality control and minimize errors.
- No training required for operation due to user-friendly interfaces.

Additional Features:
- Optional laminar airflow (LAF) hoods, RABS, or isolator enclosures for enhanced sterility.
- Cooling systems to prevent overheating and extend machine lifespan.
- Dead tray or collection tray for efficient diversion of filled and sealed ampoules.
- Safety features like gas/oxygen safety valves, pressure reducers, and stainless steel hoods for fume extraction.

FAQ for 20ml Ampoule Filling Machine

What is a 20ml Ampoule Filling Machine and what does it do?

The 20ml Ampoule Filling Machine is a fully automatic monoblock system designed to fill and hermetically seal 20ml glass ampoules with sterile liquid injectables, vaccines, serums, or pharmaceutical solutions. It integrates nitrogen flushing (pre- and post-filling), precise volumetric piston filling, neck pre-heating, and flame sealing in one continuous operation. Using the slant travel principle for gentle handling, it ensures high sterility, low breakage, and compliance with cGMP standards for pharmaceutical and biotech production.

What is the production capacity of the 20ml Ampoule Filling Machine?

Our 20ml Ampoule Filling Machine is available in multiple models with the following outputs:

AFS-1 (Single Head): Up to 25 ampoules per minute (~1,500/hour)
AFS-2 (Two Heads): Up to 50 ampoules per minute (~3,000/hour)
AFS-4 (Four Heads): Up to 100 ampoules per minute (~6,000/hour)
AFS-8 (Eight Heads): Up to 200 ampoules per minute (~12,000/hour)

Actual speed for 20ml ampoules depends on liquid viscosity and ampoule quality. All models provide consistent filling accuracy of ±1% using high-precision piston pumps.

Which ampoule sizes can the 20ml Ampoule Filling Machine handle, and how easy is changeover?

The machine is optimized for 20ml ampoules and supports:

AFS-1: 1ml to 30ml
AFS-2, AFS-4 & AFS-8: 1ml to 20ml

It works with both open-mouth and closed-mouth ampoules (Type B, C, or D). Changeover between sizes is quick with minimum changeover parts and mostly tool-less adjustments, resulting in very low downtime. The “No Ampoule – No Filling” system prevents product wastage.

How does the 20ml Ampoule Filling Machine ensure sterility and product quality?

Sterility and quality are maintained through:

Nitrogen gas flushing before, during, and after filling to remove oxygen and prevent oxidation.
Precise ampoule neck centering during flushing and filling.
Pre-warming station before flame sealing using LPG + Oxygen burners.
All product contact parts made of Stainless Steel 316L.
Optional Laminar Air Flow (LAF) cabinet for Class 100 aseptic conditions.

The compact monoblock design and slant travel mechanism minimize contamination risks and glass breakage, meeting USFDA and WHO guidelines for sterile injectable production.

What are the power requirements and key safety features of the 20ml Ampoule Filling Machine?

Power requirements are model-specific and energy-efficient:

AFS-1: 0.5 HP
AFS-2 & AFS-4: 1 HP
AFS-8: 2 HP

(All models run on 230 Volts, Single Phase, 50 Hz, 4 Wire System – customizable as per your country’s voltage.)

Key safety and operational features include safety clutches, pressure regulators, gas/oxygen safety valves, stainless steel fume extraction hoods, full accessibility for easy cleaning, PLC + HMI controls, and the “No Ampoule – No Filling” system. The machine integrates seamlessly with washing, sterilizing, inspection, and labeling equipment for a complete line.

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