Plastic Vial Filling Machine

Description

Plastic Vial Filling Machine is an automated or semi-automated piece of equipment primarily used in the pharmaceutical, biotechnology, cosmetic, and chemical industries to precisely fill, stopper, and seal plastic vials with liquids, semi-solids, powders, or suspensions. These machines ensure high accuracy, sterility, and efficiency, making them essential for producing injectable drugs, vaccines, oncology preparations, and other sensitive formulations. Unlike glass Vial Fillers, plastic vial machines are designed to handle the flexibility and chemical resistance of plastic containers, reducing breakage risks and interactions between the product and container while supporting ready-to-use (RTU) formats.

Unlike glass vial fillers, this machine is optimized for the flexible and lightweight nature of plastic vials. It ensures accurate dosing, gentle handling to avoid deformation, and reliable sealing while maintaining strict sterility standards. Controlled by a PLC system with touchscreen HMI, the machine offers consistent performance, easy operation, and full compliance with cGMP, FDA, and EU Annex 1 requirements.

  • Vial Loading and Washing: Sterile plastic vials are fed via conveyor or rotary star wheel into a washing station for rinsing and drying.

 

  • Filling: Vials are positioned under nozzles; precise volumes are dispensed.

 

  • Stoppering: Rubber stoppers are placed and seated automatically.

 

  • Capping/Sealing: Caps are applied and secured, often with vision systems for quality checks.

 

  • Inspection and Ejection: Filled vials are scanned for defects and transferred to downstream lines for labeling or packaging.

 

Vial Filling Machine handle both sterile (aseptic) and non-sterile applications, with speeds ranging from small-batch (clinical trials) to high-volume production. They are valued for their cost-effectiveness, reduced particle generation compared to glass, and adaptability to formats like nested RTU vials.

If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Working Principle of Plastic Vial Filling Machine

The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.

 

The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.

 

Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.

Technical Specification of Plastic Vial Filling Machine

Model

ALVF-40

ALVF-80

ALVF-120

ALVF – 250

Filling Heads

Two

Four

Eight

Twelve

Production Rate

Up to 40 Vials/Minute

Up to 80 Vials/Minute

Up to 150 Vials/Minute

Up to 250 Vials/Minute

Vial Diameter

15mm to 70mm

15mm to 70mm

15mm to 70mm

15mm to 70mm

Vial Height

25mm to 140mm

25mm to 140mm

25mm to 140mm

25mm to 140mm

Filling Precision

±1%

±1%

±1%

±1%

Power Required

1 H.P.

1.5 H.P.

2 H.P.

2 H.P.

Electrical Characteristics

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

Overall Dimension

2050mm (L) x 850mm (W) x 1700mm (H)

2200mm (L) x 850mm (W) x 1700mm (H)

3000mm (L) x 945mm (W) x 1700mm (H)

3500mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Applications of Vial Filling Machine

Advantages of Plastic Vial Filling Machine

Reduced Breakage and Improved Safety

Lower Weight and Transportation Cost Savings

High Filling Accuracy and Minimal Product Waste

Enhanced Sterility and Lower Contamination Risk

Higher Production Speed and Efficiency

Better Flexibility and Versatility

Key Features of Plastic Vial Filling Machine

  • Filling Mechanism: Employs peristaltic, piston, or time-pressure pumps for volumetric dosing, adjustable for vial sizes from 2 ml to 500 ml. It supports diverse viscosities and minimizes waste through sensors that detect under- or over-fills.

 

  • Stoppering and Closing: Automatically inserts rubber stoppers or plugs, followed by capping with plastic press-fit closures, aluminum seals, or crimps. This occurs in a sterile Grade A environment with laminar airflow to prevent contamination.

 

  • Modular Design: Often compact and configurable for cleanrooms or isolators, with quick changeovers for different vial formats without manual adjustments.

 

  • Sterilization Integration: Includes pre-washing with Water for Injection (WFI), depyrogenation via dry heat tunnels, and post-filling external cleaning to remove particles.

 

  • Compliance and Safety: cGMP-compliant, with features like no-vial/no-fill sensors, rejection of defective vials, and compatibility with clean-in-place (CIP) systems for hygiene.

FAQ for Plastic Vial Filling Machine

Key advantages include:

  • Shatterproof plastic vials reduce breakage, product loss, and safety risks
  • Significantly lower weight, leading to reduced transportation and storage costs
  • High filling accuracy (±0.5% to ±1%) with minimal product wastage
  • Gentle handling to prevent deformation of flexible plastic containers
  • Higher production speeds and easier line integration compared to glass vial lines
  • Lower overall packaging and operational costs while maintaining GMP compliance

It is especially suitable for high-volume or hospital-use sterile products.

The machine is built for aseptic processing in ISO Class 5 / Grade A environments, often with RABS or isolator compatibility. It uses advanced filling technologies such as peristaltic pumps or servo-driven piston pumps for precise dosing. Features like “No Vial – No Fill” interlock, smooth plastic-friendly vial handling, SS316L product contact parts, and easy-to-clean design help maintain sterility and achieve consistent fill volumes with minimal particulate generation.

Production capacity usually ranges from 60 to 300+ vials per minute, depending on the number of filling heads and product viscosity. It can handle a wide range of plastic vial sizes from 0.5 ml to 100 ml (and sometimes higher). The machine is optimized for lightweight plastic formats, offering fast changeover and reliable performance even at high speeds.

Choose a Plastic Vial Filling Machine when:

  • You need shatterproof, lightweight, and cost-effective packaging
  • Breakage reduction and lower shipping costs are priorities
  • The product is intended for hospital, veterinary, or high-volume use
  • You want easier handling and reduced risk of glass-related contamination or injuries

Glass vial fillers are still preferred for certain ultra-sensitive biologics requiring highest thermal resistance, while plastic vial fillers excel in safety, logistics savings, and user convenience.

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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