Single Stroke Vial Filling Machine

Q: What is a Single Stroke Vial Filling Machine?

A Single Stroke Vial Filling Machine (also known as Single Syringe Vial Filler or Model VFCS 20) is a compact, cGMP-compliant monoblock machine designed for precise filling of sterile liquids into glass vials. It uses a single-stroke piston or syringe mechanism to deliver an accurate volume in one continuous motion per vial. It typically integrates liquid filling with rubber stoppering and is ideal for low-to-medium volume production, R&D labs, pilot batches, clinical trials, and small-scale pharmaceutical or biotech manufacturing.

Q: What is the production capacity and vial size range of the Single Stroke Vial Filling Machine?

The machine has a production output of up to 20 vials per minute . It can handle vial sizes from 2ml to 100ml (with compatibility up to 250ml in some configurations) and fill volumes ranging from 2ml to 250ml in a single stroke. This makes it perfect for flexible small-batch production without requiring multiple machines or frequent changeovers.

Q: What is the filling accuracy of the Single Stroke Vial Filling Machine?

The standard filling accuracy is ±1% , depending on the liquid characteristics and vial size. The machine features a “ No Vial – No Filling ” system to prevent product wastage and ensure consistent dosing. Higher accuracy (up to ±0.5%) is achievable with optional servo-controlled pumps. All contact parts are made of SS 316L for corrosion resistance and compliance with sterile injectable standards.

Q: Which industries and products is the Single Stroke Vial Filling Machine suitable for?

This machine is widely used in the pharmaceutical, biotech, veterinary, and cosmetic industries . It is ideal for filling sterile injectables such as: Vaccines Antibiotics Biologics Suspensions Other liquid formulations It is especially suitable for R&D labs, pilot-scale production, and small-batch manufacturing where precision, sterility, and cost-effectiveness are critical.

Description

Single Stroke Vial Filling Machine is a specialized semi-automatic or automatic pharmaceutical packaging equipment designed primarily for the precise filling of liquid or powder formulations into sterile glass vials used in injectable drug production. It operates on a “single stroke” principle, where the filling mechanism—typically a piston-driven syringe or volumetric pump—delivers the exact volume of product in one continuous linear motion (stroke) per vial, ensuring high accuracy and minimal product waste. This contrasts with multi-stroke systems that might require multiple cycles for larger volumes. These machines are widely used in cleanroom environments to meet cGMP (Current Good Manufacturing Practice) standards, reducing contamination risks and supporting aseptic processing for vaccines, biologics, oncology drugs, and other injectables.

It operates on the single stroke principle, where the filling syringe or piston delivers the exact required volume in one continuous linear motion per vial. This design ensures superior filling accuracy, minimal product wastage, and consistent dosing, making it ideal for small to medium batch production. It operates on the single stroke principle, where the filling syringe or piston delivers the exact required volume in one continuous linear motion per vial. This design ensures superior filling accuracy, minimal product wastage, and consistent dosing, making it ideal for small to medium batch production. The machine integrates liquid filling with rubber stoppering in a single unit and is built to meet stringent cGMP standards. It is specially suited for aseptic processing under laminar airflow in cleanroom environments, minimizing the risk of cross-contamination.

If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Salient Features of Single Stroke Vial Filling Machine

Small footprint cGMP complied machine.
Filling accuracy of ±1% depends upon liquid characteristics & vial size.
No cross contamination.
All Contact Parts Made from Stainless Steel 316L & framework by Stainless Steel 304.
Variable A.C. frequency drive for speed adjustment.
2ml to 250ml fill dosage in one machine.

Digital Vial Counter for counting production output.
In-feed Turn Table/ Unscrambler for automatic feeding of objects.
On-line Mechanism., “No Vial – No Filling” System.
Easy to validate filling system for small/large batch production.
IQ/OQ documentation can be provided.
PLC system with Graphical User Interface. (Optional)

Working Principle of Single Stroke Vial Filling Machine

Our Vial Filling Machines comprise of a stainless steel slat conveyor and vials are transferred using this conveyor. Once the vials reach the filling station from the conveyor, the next phase of operation begins. Filling station is equipped with a number of heads for quicker operations. Here precise filling of vials takes place and they are now moved for the stoppering process. This is a very crucial part of the entire process as this ensures the vials remain immaculate and the product inside the vials also remains preserved. Pharmaceutical products must always remain free of external contaminants and other factors. The medicinal value may get compromised otherwise and hence Vial Filling and Capping Machines are indispensable to the pharmaceutical industry.

Technical Specification of Single Stroke Vial Filling Machine

Model	VFCS 20
Production Output	Up to 20 vials/minute
Vial Size	2ml to 100ml
Filling Accuracy	±1% to the filling volume
Power Load	1 H. P.
Overall Dimension	1700mm (L) x 900mm (W) x 1700mm (H) approx.
Net Weight	300 kgs. approx.
Gross Weight	450 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Automatic Vial Filling Machine

High Speed Vial Filling Machine

Vial Liquid Filling Machine

Vial Powder Filling Machine

Automatic Vial Filling and Rubber Stoppering Machine

Lab Scale Vial Filling Stoppering & Cap Sealing Machine

Injectable Vial Powder Filling & Stoppering Machine

Peristaltic Pump based Vial Filling Machine

Applications of Vial Filling Machine

Advantages of Single Stroke Vial Filling Machine

Precision and Efficiency: Single-stroke design ensures consistent dosing without overfilling, reducing rework.

Cost-Effective: Lower upfront cost compared to fully robotic systems, with easy format changes for various vial diameters (e.g., 13 mm or 20 mm).

Hygiene: Stainless steel construction (SS 304/316) and enclosed design minimize cross-contamination.

Key Components of Single Stroke Vial Filling Machine

Filling Mechanism: Syringes (often made of SS 316L for corrosion resistance) are mounted on an eccentric block driven by a main gearbox. The stroke length of the piston is adjustable to control fill volume (e.g., from 0.5 ml to 20 ml or more), allowing flexibility for different vial sizes (2 ml to 50 ml). Filling occurs via needles or nozzles that penetrate the vial for bottom-up delivery, minimizing foam and air entrapment.

Vial Handling: A star wheel (rotary indexing table) securely holds vials during the filling operation, ensuring precise positioning. Sensors enable a “No Vial-No Fill” function to prevent errors or spills.

Integration with Other Processes: Often combined with rubber stoppering and aluminum cap sealing in a monoblock setup. After filling, a vibrating chute feeds rubber stoppers, which are pressed into place by a spring-loaded roller. Capping follows via a single-disc or roll-on mechanism for tamper-evident seals.

Speed and Capacity: Typically processes 20–60 vials per minute (depending on model), suitable for small to medium batch production. Higher-speed variants can reach 100+ vials/min with motion-filling nozzles that move synchronously with vials.

Safety and Compliance: Designed for sterile areas under laminar airflow, with minimal dead zones for easy cleaning (CIP/SIP compatible). Features include servo-controlled pumps for ±0.5% fill accuracy, inline weight checks, and low-particle generation to comply with EU GMP Annex 1 and FDA regulations.

FAQ for Single Stroke Vial Filling Machine

What is a Single Stroke Vial Filling Machine?

A Single Stroke Vial Filling Machine (also known as Single Syringe Vial Filler or Model VFCS 20) is a compact, cGMP-compliant monoblock machine designed for precise filling of sterile liquids into glass vials. It uses a single-stroke piston or syringe mechanism to deliver an accurate volume in one continuous motion per vial.

It typically integrates liquid filling with rubber stoppering and is ideal for low-to-medium volume production, R&D labs, pilot batches, clinical trials, and small-scale pharmaceutical or biotech manufacturing.

What is the production capacity and vial size range of the Single Stroke Vial Filling Machine?

The machine has a production output of up to 20 vials per minute. It can handle vial sizes from 2ml to 100ml (with compatibility up to 250ml in some configurations) and fill volumes ranging from 2ml to 250ml in a single stroke.

This makes it perfect for flexible small-batch production without requiring multiple machines or frequent changeovers.

What is the filling accuracy of the Single Stroke Vial Filling Machine?

The standard filling accuracy is ±1%, depending on the liquid characteristics and vial size. The machine features a “No Vial – No Filling” system to prevent product wastage and ensure consistent dosing.

Higher accuracy (up to ±0.5%) is achievable with optional servo-controlled pumps. All contact parts are made of SS 316L for corrosion resistance and compliance with sterile injectable standards.

What are the key features of the Single Stroke Vial Filling Machine?

Key features include:

Compact cGMP-compliant design with small footprint
Variable AC frequency drive for speed control
Digital vial counter
In-feed turntable/unscrambler for automatic vial feeding
“No Vial – No Filling” mechanism
Easy cleaning and quick format changeover
Stainless Steel 316L contact parts and SS 304 framework
Optional PLC system with HMI and IQ/OQ documentation

It is designed for operation under laminar airflow to maintain sterility and minimize cross-contamination.

Which industries and products is the Single Stroke Vial Filling Machine suitable for?

This machine is widely used in the pharmaceutical, biotech, veterinary, and cosmetic industries. It is ideal for filling sterile injectables such as:

Vaccines
Antibiotics
Biologics
Suspensions
Other liquid formulations

It is especially suitable for R&D labs, pilot-scale production, and small-batch manufacturing where precision, sterility, and cost-effectiveness are critical.

Countries We Export to

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

GET A QUOTE!