Injectable Glass Ampoule Washing Machine is specialized pharmaceutical equipment designed to thoroughly clean and sterilize glass ampoules used for injectable medications, vaccines, or other critical substances. These machines ensure ampoules are free from contaminants, dust, microbes, and pyrogens before filling, maintaining the sterility and safety required for injectable products.
The primary function of an injectable glass ampoule washing machine is to clean the internal and external surfaces of ampoules (typically 1-20ml in size) to eliminate impurities, ensuring compliance with Good Manufacturing Practices (GMP) and regulatory standards like FDA, EMA, and WHO. This is critical to prevent contamination that could compromise the integrity of the pharmaceutical formulation.
Ampoules are loaded manually or automatically onto an infeed tray or conveyor. The transport system (e.g., feed screw or star wheel) moves them to the washing station, where grippers or clamps invert the ampoules. A series of high-pressure jet washes (using recycled water, purified water, WFI, and compressed air) clean the internal and external surfaces. Nozzles track and insert into ampoules for precise cleaning, controlled by solenoid valves or PLC. After washing, ampoules are dried with filtered compressed air and discharged via an outfeed system (e.g., feed worm or conveyor) to a sterilization tunnel or filling line under sterile conditions.
Ampoules feed from the Infeed tray are received on an Infeed Feed worm then moves on Infeed starwheel. The Grippers picks up the Ampoule from Infeed Star Wheel and invert it in neck down position over washing needles and move along with the needle bar for Washing. Ampoules traveling in neck down position above washing needles and moves along with the Needle bar ensures maximum time for washing once the needle enter in the Ampoule neck. Machine having six different washing stations each of 6 needles for optimum Washing and the sequence can be adjusted as per requirements. Washer also having external wash for optimum washing of ampoules.
On completion of a cycle, washed Ampoules are again inverted to neck upward position and feed to output star wheel. Washed Ampoules received from output starwheel can be collected on Output Tray or can be pushed to tunnel. A separate pumping station (optional) gives the right quantum of water at the desired pressure. In the absent of separate pumping station, we can provide the re-circulation & siliconization system on request.
INTERNAL CLEANING:
The AVRW is equipped with 6 internal cleaning stations and each station has 6 cleaning needles making up a total of 36 cleaning needles. Each cleaning station is supplied via a pipe connected to the cleaning media-making washing area. This not only reduces the risk of particle generation, but also simplifies maintenance and cleaning efforts while saving time.
EXTERNAL CLEANING
The 3 external cleaning stations mounted in a stationary position above the ampoule can be easily adjusted for a specific height, angle and lateral position. Each cleaning station receives cleaning media-making through a pipe connected to the cleaning media-making washing area.
CLEANING MEDIA PRINCIPAL:
WFI, Purified water and air cleaning station are synchronized with the ampoule by reciprocating motion. Design is such that these media are put to use only when needles motion in forward direction. WFI consumption is further reduced by collecting the WFI in re-circulating water tank to be used later on in the pre-washing station.
Model | AVRW 120 | AVRW 240 |
Production Output | Up to 100 per minute | Up to 200 per minute |
Ampoule Diameter | 9mm to 21.5mm | 9mm to 21.5mm |
Ampoule Height | 60mm to 140mm | 60mm to 140mm |
Power Load | 4 H.P. | 5.5 H.P. |
Power Voltage | 440 Volts, 3 Phase 50 Hertz, 4 wire system | 440 Volts, 3 Phase 50 Hertz, 4 wire system. |
Optional Accessories |
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Utility |
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Water Tank & Pump | 3 nos. each with 25 liters Capacity & Centrifugal pump | 3 nos. each with 25 liters Capacity & Centrifugal pump |
Overall Dimension: | 2050mm (L) X 2000mm (W) X 1210mm (H) approx. | 2450mm (L) X 2000mm (W) X 1300mm (H) approx. |
Net Weight | 700 kgs. approx. | 900 kgs. approx. |
Gross Weight | 1000 kgs. approx. | 1300 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
1st wash | Recycled Water (WFI) |
2nd wash | Compressed Air |
3rd wash | DM Water |
4th wash | Compressed Air |
5th wash | Water for Injection (WFI) |
6th wash | Compressed Air |
The machine is available in two main models:
It is suitable for medium to large-scale pharmaceutical production of injectable products.
The machine handles glass ampoules ranging from 1ml to 10ml (extendable up to 20ml in some configurations).
Change parts are provided for different sizes, and the washing sequence can be customized as per requirement.
Ampoules are fed via an infeed tray and star wheel. Grippers pick them up, invert them neck-down, and move them over stationary washing needles across 6 internal washing stations (with 3 water washes + 3 compressed air washes). External washing is also performed simultaneously. Independent circuits for each zone prevent cross-contamination. After washing, ampoules are re-inverted neck-up and discharged to an output tray or directly to a sterilization tunnel. The typical cycle is: Recycled Water → Air → DM Water → Air → WFI → Air.
All product-contact parts are made of AISI 316L Stainless Steel, while non-contact parts use AISI 304 Stainless Steel and engineering plastics, ensuring full cGMP compliance. Utilities required:
Optional features include PLC with HMI, separate pumping station with 3 tanks, recirculation system, and safety cabinet.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.
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