

An Injectable Glass Ampoule Washing Machine is specialized pharmaceutical equipment designed to thoroughly clean and prepare glass ampoules used for injectable medications, vaccines, and other critical sterile substances. These high-precision machines ensure ampoules are completely free from contaminants, dust, microbes, pyrogens, and particulate matter before filling, maintaining the stringent sterility and safety standards required for parenteral products.
Injectable drugs demand the highest level of purity. Even minor contamination in glass ampoules can lead to product recalls, regulatory issues, or serious patient health risks. An injectable glass ampoule washing machine addresses this by delivering consistent, validated cleaning of both internal and external surfaces. It plays a vital role in the aseptic processing chain, preparing containers for filling, sealing, and final sterilization.
Ampoules fed from the infeed tray are received by the infeed feed worm and then transferred to the infeed star wheel. Grippers pick up each ampoule from the infeed star wheel, invert it into the neck-down position over the washing needles, and move it along with the needle bar for washing. Traveling in the neck-down position above the washing needles and moving with the needle bar ensures maximum washing time once the needles enter the ampoule neck. The machine has six different washing stations, each equipped with six needles for optimum washing; the sequence can be adjusted as required. The washer also includes an external wash for thorough cleaning of the ampoules.
At the end of the cycle, the washed ampoules are inverted back to the neck-up position and transferred to the output star wheel. Ampoules received from the output star wheel can be collected on the output tray or pushed into a tunnel. An optional separate pumping station supplies the correct volume of water at the desired pressure. In the absence of a separate pumping station, a re-circulation and siliconization system can be provided on request.
INTERNAL CLEANING: The AVRW is equipped with six internal cleaning stations, each having six cleaning needles, for a total of 36 cleaning needles. Each station is supplied through a pipe connected to the cleaning media-making washing area. This design reduces the risk of particle generation, simplifies maintenance and cleaning, and saves time.
EXTERNAL CLEANING: Three external cleaning stations are mounted in a stationary position above the ampoules and can be easily adjusted for height, angle, and lateral position. Each station receives cleaning media through a pipe connected to the cleaning media-making washing area.
CLEANING MEDIA PRINCIPLE: WFI, purified water, and air cleaning stations are synchronized with the ampoule through reciprocating motion. The design ensures that these media are used only when the needles move in the forward direction. WFI consumption is further reduced by collecting the used WFI in a re-circulating water tank for later use in the pre-washing station.
Model | AVRW 120 | AVRW 240 |
Production Output | Up to 100 per minute | Up to 200 per minute |
Ampoule Diameter | 9mm to 21.5mm | 9mm to 21.5mm |
Ampoule Height | 60mm to 140mm | 60mm to 140mm |
Power Load | 4 H.P. | 5.5 H.P. |
Power Voltage | 440 Volts, 3 Phase 50 Hertz, 4 wire system | 440 Volts, 3 Phase 50 Hertz, 4 wire system. |
Optional Accessories |
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Utility |
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Water Tank & Pump | 3 nos. each with 25 liters Capacity & Centrifugal pump | 3 nos. each with 25 liters Capacity & Centrifugal pump |
Overall Dimension: | 2050mm (L) X 2000mm (W) X 1210mm (H) approx. | 2450mm (L) X 2000mm (W) X 1300mm (H) approx. |
Net Weight | 700 kgs. approx. | 900 kgs. approx. |
Gross Weight | 1000 kgs. approx. | 1300 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
1st wash | Recycled Water (WFI) |
2nd wash | Compressed Air |
3rd wash | DM Water |
4th wash | Compressed Air |
5th wash | Water for Injection (WFI) |
6th wash | Compressed Air |
The Injectable Glass Ampoule Washing Machine is a high-performance, cGMP-compliant rotary washing system designed to thoroughly clean the internal and external surfaces of glass ampoules used for injectable drugs, vaccines, and sterile solutions. It removes dust, particles, fibers, microbes, and pyrogens using multiple high-pressure water and air wash cycles, ensuring ampoules meet the strict sterility and cleanliness standards required before filling and sealing.
The machine is available in two main models:
It is suitable for medium to large-scale pharmaceutical production of injectable products.
The machine handles glass ampoules ranging from 1ml to 10ml (extendable up to 20ml in some configurations).
Change parts are provided for different sizes, and the washing sequence can be customized as per requirement.
Ampoules are fed via an infeed tray and star wheel. Grippers pick them up, invert them neck-down, and move them over stationary washing needles across 6 internal washing stations (with 3 water washes + 3 compressed air washes). External washing is also performed simultaneously. Independent circuits for each zone prevent cross-contamination. After washing, ampoules are re-inverted neck-up and discharged to an output tray or directly to a sterilization tunnel. The typical cycle is: Recycled Water → Air → DM Water → Air → WFI → Air.
All product-contact parts are made of AISI 316L Stainless Steel, while non-contact parts use AISI 304 Stainless Steel and engineering plastics, ensuring full cGMP compliance. Utilities required:
Optional features include PLC with HMI, separate pumping station with 3 tanks, recirculation system, and safety cabinet.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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