Ampoule Washing Machine

Description

An ampoule washing machine is a specialized, high-performance piece of equipment engineered for the pharmaceutical, veterinary, and biotechnology sectors. It is designed to clean glass ampoules and, in many configurations, vials with exceptional precision and reliability. These machines play a vital role in ensuring the highest levels of sterility and product safety by thoroughly removing contaminants such as dust particles, glass fibers, microbial residues, and chemical traces before the containers are filled with injectable drugs, vaccines, biologics, or other sensitive pharmaceutical formulations.

 

In today’s stringent regulatory environment, maintaining cGMP (current Good Manufacturing Practices) compliance is essential. A modern pharmaceutical ampoule washing machine helps manufacturers meet FDA, EMA, WHO, and other international standards by delivering consistent, validated cleaning results that minimize contamination risks and protect formulation integrity.

 

Glass ampoules are widely used for sterile injectable products because they provide excellent barrier properties and long-term stability. However, during manufacturing, storage, and transportation, ampoules can accumulate various contaminants. Manual cleaning is inefficient, inconsistent, and introduces human error. Automated ampoule washing machines solve these challenges through advanced engineering, offering repeatable processes that significantly reduce particulate matter and bioburden. 

Working Principle of Ampoule Washing Machine

Ampoules fed from the infeed tray are received by an infeed feed worm and then transferred to the infeed starwheel. Grippers pick up each ampoule from the infeed starwheel, invert it into the neck-down position over the washing needles, and travel together with the needle bar during the washing process. With the ampoules moving neck-down above the washing needles and advancing in tandem with the needle bar, maximum washing time is achieved once the needles enter the ampoule necks. The machine is equipped with six different washing stations, each containing six needles, for optimum washing; the sequence of these stations can be adjusted as required. The washer also includes an external wash for thorough cleaning of the ampoules.

 

At the end of the cycle, the washed ampoules are inverted back to the neck-up position and transferred to the output starwheel. From the output starwheel, the washed ampoules can be collected on an output tray or pushed into a tunnel. An optional separate pumping station supplies the correct volume of water at the required pressure. If a separate pumping station is not provided, a re-circulation and siliconization system can be supplied on request.

 

INTERNAL CLEANING: The AVRW is fitted with six internal cleaning stations. Each station has six cleaning needles, giving a total of 36 cleaning needles. Every cleaning station is supplied through a pipe connected to the cleaning-media washing area. This arrangement reduces the risk of particle generation, simplifies maintenance and cleaning, and saves time.

 

EXTERNAL CLEANING: Three external cleaning stations are mounted in a fixed position above the ampoules and can be easily adjusted for height, angle, and lateral position. Each station receives cleaning media through a pipe connected to the cleaning-media washing area.

 

CLEANING MEDIA PRINCIPLE: WFI, purified water, and air cleaning stations are synchronized with the ampoules by reciprocating motion. The design ensures that these media are used only when the needles move in the forward direction. WFI consumption is further reduced by collecting the WFI in a re-circulating water tank for subsequent use in the pre-washing station.

Technical Specification of Ampoule Washing Machine

Model

AVRW 120

AVRW 240

Production Output

Up to 100 per minute

Up to 200 per minute

Ampoule Diameter

9mm to 21.5mm

9mm to 21.5mm

Ampoule Height

60mm to 140mm

60mm to 140mm

Power Load

4 H.P.

5.5 H.P.

Power Voltage

440 Volts, 3 Phase 50 Hertz, 4 wire system

440 Volts, 3 Phase 50 Hertz, 4 wire system.

Optional Accessories

  • Programmable Logic Control (System) with HMI
  • Safety Cabinet with doors
  • Programmable Logic Control (System) with HMI
  • Safety Cabinet with doors

Utility

  • Air – 20 CFM
  • Water – 200 to 500 liters per hour depend upon ampoule size.
  • Air – 20 CFM
  • Water – 200 to 500 liters per hour depend upon ampoule size.

Water Tank & Pump

3 nos. each with 25 liters Capacity & Centrifugal pump

3 nos. each with 25 liters Capacity & Centrifugal pump

Overall Dimension:

2050mm (L) X 2000mm (W) X 1210mm (H) approx.

2450mm (L) X 2000mm (W) X 1300mm (H) approx.

Net Weight

700 kgs. approx.

900 kgs. approx.

Gross Weight

1000 kgs. approx.

1300 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Washing Machine

Applications of Ampoule Washing Machine

Benefits of Ampoule Washing Machine

Ensures sterility and cleanliness critical for pharmaceutical safety.

High-speed operation improves production efficiency.

Customizable washing sequences and modular designs cater to diverse needs.

Reduces manual handling, minimizing contamination risks.

Washing Cycle of Ampoule Washing Machine

1st wash           

Recycled Water (WFI)

2nd wash

Compressed Air

3rd wash          

DM Water

4th wash

Compressed Air

5th wash

Water for Injection (WFI)

6th wash

Compressed Air

FAQ for Automatic Ampoule Washing Machine

The machine is available in two standard models:

  • AVRW 120: Up to 100 ampoules per minute
  • AVRW 240: Up to 200 ampoules per minute

Higher-speed versions can reach up to 300–400 ampoules per minute depending on configuration. The output is adjustable with a digital speed indicator.

It is suitable for glass ampoules from 1ml to 10ml (extendable up to 20ml).

  • Ampoule Diameter: 9 mm to 21.5 mm
  • Ampoule Height: 60 mm to 140 mm

Interchangeable change parts allow easy switching between different sizes.

Ampoules are fed from the infeed tray to a star wheel. Grippers hold them by the neck, invert them (neck-down), and pass them over stationary washing needles across 6 internal washing stations (providing 3 water washes + 3 air washes). External washing is performed simultaneously. Each zone has independent circuits to prevent cross-contamination. After washing, ampoules are re-inverted (neck-up) and discharged to the output tray or directly to a sterilization tunnel. A typical sequence is: Recycled Water → Air → DM Water → Air → WFI → Air.

All product-contact parts are made of AISI 316L Stainless Steel, while non-contact parts use AISI 304 Stainless Steel and FDA-approved engineering plastics, ensuring full cGMP compliance. Utilities required:

  • Power: 4 HP (AVRW 120) / 5.5 HP (AVRW 240), 440V, 3 Phase, 50 Hz
  • Compressed Air: 20 CFM
  • Water: 200–500 liters per hour (depending on ampoule size)

Optional features include PLC with HMI, separate pumping station with 3 tanks, recirculation system, siliconization, and safety cabinet.

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Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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