Onion Skin Ampoule Filler

Description

Onion Skin Ampoule Filler or onion skin ampoule filling Machine is suitable for filling onion skin ampoules. Machine designed to work with thin glass thickness onion skin tubes. These tubes are widely uses in biomedical industry for specific operations. Diameter and length of these tubes are lesser compared to standard pharmaceutical ampoules. Machine is suitable to fill 0.2ml to 5ml liquid into onion skin ampoules with precision liquid discharge system.

Onion skin ampoule filler machine having different machine models which can produce ampoules ranging from 25 ampoules per minute to 200 ampoules per minute. We have single head, double head, four head, six head and eight head machine models in this machine. We have option of different filling mechanism which includes peristaltic pump type filling, servo driven piston pump filling and mechanical piston pump filling. We can offer any of these as per user requirements.

Onion skin ampoules also called as biological indicators. Glass of these type of packing is kept thin, so that end user can easily break the ampoule during usage of product. As thickness of these ampoules is less, so it is also called as crushable glass ampoules. Sturdy design, easy operation and economical price are the key aspects which put Adinath in elite league of onion skin ampoule filling machine manufacturers in India.

Salient Features of Onion Skin Ampoule Filler

Compact model.
Ampoule neck centering during gas flushing and filling operations.
“No Ampoule – No Filling” system.
All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.

Full accessibility allows easy maintenance.
Possibility of nitrogen gas flushing before, during and after filling.
Machine equipped with pre-warming station.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Onion Skin Ampoule Filler

The sterilized ampoule tray directly loaded in to slant hopper of the unit. The Synchronized star wheel delivers ampoules, one by one on moving eccentric ampoule rack in single/double/four/six/eight. During the movement of ampoule machine perform below mentioned operations:

Pre-Gassing: Nitrogen or argon is flushed into the ampoules to create an inert environment.
Filling: Precise liquid volumes (0.2ml to 25ml) are dispensed using piston or peristaltic pumps.
Post-Gassing: Additional nitrogen/argon flushing occurs to maintain sterility.
Pre-Warming and Sealing: Ampoules are warmed at a low-pressure flame station, then rotated at the sealing station for uniform sealing. Special rollers ensure consistent sealing quality.
Collection: Sealed ampoules are automatically collected in an upright position on a dead tray for further processing.

Technical Specification of Onion Skin Ampoule Filler

Model	AFS-1	AFS-2	AFS-4	AFS-8
No. of Head	Single	Two	Four	Eight
Syringes	One	Double	Four	Eight
Ampoule Sizes	1 ml to 30 ml	1 ml to 30 ml	1 ml to 20 ml	1 ml to 20 ml
Filling Speed	Up to 25 ampoules/minute	Up to 50 ampoules/minute	Up to 100 ampoules/minute	Up to 200 ampoules/minute
Filling Precision	± 1%	± 1%	± 1%	± 1%
Filling Pump	Piston Pump	Piston Pump	Piston Pump	Piston Pump
Burner Gas	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)
Nitrogen Arrangement	Before & After Filling	Before & After Filling	Before & After Filling	Before & After Filling
Number of Fill Nozzles	One	Two	Four	Eight
Number of Nitrogen Nozzles	Two	Four	Eight	Sixteen
Number of Sealing Burners	Two	Four	Eight	Sixteen
Power Required	0.5 H.P.	1 H.P.	1 H.P.	2 H.P.
Power Voltage	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L
Overall Dimension	915mm (L) x 610mm (W) x 965mm (H) approx.	915mm (L) x 760mm (W) x 965mm (H) approx.	1200mm (L) x 1070mm (W) x 965mm (H) approx.	2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Onion Skin Ampoule Filler

Excellent Handling of Thin & Variable Onion Skin Ampoules

High Filling Precision with Minimal Wastage

Superior Sterility and Product Protection

Compact, cGMP-Compliant & Easy to Operate/Maintain

High Output with Flexibility

Key Features and Design of Onion Skin Ampoule Filler

Purpose and Applications: The machine is engineered to fill and seal onion skin ampoules, which are commonly used for packaging agro-insecticides, veterinary medicines, cosmetics, and chemicals. It is also suitable for biological indicator tubes used in specific biomedical applications, such as mobile detection systems where ampoules are crushed to mix chemicals with a swab for detecting residues.

Construction: Built on a stainless steel square pipe frame (AISI SS 304 for non-contact parts and AISI SS 316L for contact parts), the machine is encased in stainless steel with a matte finish, ensuring durability, hygiene, and compliance with cGMP and FDA standards. A large bottom opening facilitates easy cleaning and maintenance.

Filling Mechanism: Operates on a volumetric piston-pump or peristaltic pump system, achieving high precision (up to 1% accuracy) for filling volumes ranging from 0.2ml to 25ml in a single dose. Some models offer servo-driven or mechanical piston pump options for enhanced control.

Sealing Process: Uses oxygen and LPG (propane) or oxyhydrogen gas (generated via water electrolysis, replacing traditional gas cylinders) for flame sealing. Specially designed burners accommodate thin glass (0.3mm–0.8mm), with pre-warming and rotation stations ensuring uniform sealing. Burned-off ampoule tips are clipped and ejected into a separate container.

Output Capacity: Depending on the model (single, double, four, six, or eight-head), production rates range from 10 to 250 ampoules per minute.

Ampoule Handling: Supports ampoules with a minimum diameter of 7mm and height of 55mm, with no upper limit for size, as machines can be customized. The slant travel design accommodates variations in ampoule neck dimensions, thickness, and ovality.

Gas Flushing: Features nitrogen or argon flushing before and after filling to ensure product stability and sterility.

Automation and User-Friendly Design: Equipped with a synchronized star wheel and eccentric rack system, ampoules are fed from a hopper, transferred to a transport rack, and processed in batches (1/2/4/6/8 ampoules per stroke). The machine includes a “No Ampoule – No Filling” system, pre-heating stations, and a dead tray for upright collection of sealed ampoules. Format parts can be changed by hand without tools, and a pendant-type electrical control panel enhances operational ease.

Compact Footprint: Designed for cleanroom integration with minimal maintenance and easy sterilization, reducing contamination risks.

FAQ for Onion Skin Ampoule Filler

What is an Onion Skin Ampoule Filler?

An Onion Skin Ampoule Filler (also known as Onion Skin Ampoule Filling and Sealing Machine) is a specialized pharmaceutical machine designed for filling and sealing thin-walled glass ampoules, commonly called “onion skin” or crushable ampoules. These ampoules have very thin glass walls (typically 0.2–0.3 mm), making them easy to break or crush for single-use applications like biological indicators, diagnostic kits, or mobile detection systems. The machine handles small-diameter tubes (as low as 6–7 mm) and fills precise volumes of liquids, from 0.2 ml to 30 ml depending on the model.

What are the main applications of Onion Skin Ampoule Filler Machines?

Onion skin ampoule fillers are widely used in:

Pharmaceuticals and biotechnology (for biological indicators and injectable solutions)
Veterinary medicines
Cosmetics and serums
Chemical and agrochemical industries (e.g., agro-insecticides)
Diagnostic and testing kits where the ampoule needs to be easily crushed by the end user

They are ideal for sterile, small-volume liquid filling in crushable glass tubes.

What filling capacities and speeds does the Onion Skin Ampoule Filler offer?

Our Onion Skin Ampoule Filler is available in multiple head configurations (Single, Double, Four, Six, or Eight heads).

Filling range: Typically 0.2 ml to 30 ml (model-dependent)
Output speed: From 25–50 ampoules per minute (lab/small scale) up to 200 ampoules per minute (high-speed models)
Accuracy: ±1% or better with volumetric piston pumps or servo-driven systems

It can handle ampoule diameters starting from 6–7 mm and heights from 55 mm onwards.

What are the key features and advantages of your Onion Skin Ampoule Filler?

Compact footprint and easy handling
Suitable for thin-walled “onion skin” or crushable glass ampoules
High filling accuracy with no-drip filling nozzles
Gas sealing (LPG + Oxygen) for perfect hermetic seals
Dead tray for safe collection of sealed ampoules
Contact parts made from high-grade stainless steel (SS 316) for GMP compliance
Easy changeover for different ampoule sizes
Low maintenance and economical operation

These features make it highly flexible for various open-mouth thin glass tubes.

How does the Onion Skin Ampoule Filler ensure product safety and compliance?

The machine is designed with GMP-compliant construction using non-reactive materials to maintain sterility. It features precise volumetric filling, flame sealing to create airtight closures, and systems to minimize contamination. Optional configurations include peristaltic pumps or servo piston filling for sensitive products. The design also includes safety features like clipper elimination of glass tips and separate collection trays, ensuring operator safety and regulatory compliance for pharmaceutical production.

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