2ml Ampoule Filler

Description

2ml Ampoule Filler is a specialized machine designed for the precise filling and sealing of 2ml glass ampoules, commonly used in pharmaceutical, biotech, cosmetic, and chemical industries. Below is a detailed description based on current industry standards and available information: 2ml Ampoule Filler is a compact, automated or semi-automated machine engineered to fill and seal 2ml glass ampoules with liquids, such as injectable drugs, serums, or other sterile solutions. These machines ensure high accuracy, sterility, and compliance with cGMP (current Good Manufacturing Practices) standards, making them ideal for small to medium-scale production in pharmaceutical and cosmetic applications.

Output Needs: Choose single or double-head fillers for small-scale production (1,500–4,500 ampoules/hour) or multi-head (four, six, or eight) for higher outputs (up to 12,000 ampoules/hour).

Ampoule Type: Ensure the machine supports closed or open 2ml ampoules

Sterility Requirements: Opt for models with laminar airflow or isolator systems for enhanced aseptic conditions in pharmaceutical applications.

This machine ensures compliance with cGMP standards for sterile injectable filling. If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Salient Features of 2ml Ampoule Filler

Compact model as per cGMP standard.
Higher production output up to 12000 Ampoules per hour.
“No Ampoule – No Filling” system.
Machine equipped with pre-warming station.
Full accessibility allows easy maintenance.
Flow Meters for regulating flames easily.

All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Minimum change over parts from 1ml to 10ml ampoule size.
Ampoule neck centering during gas flushing and filling operations.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of 2ml Ampoule Filler

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Technical Specification of 2ml Ampoule Filler

Model	AFS-1	AFS-2	AFS-4	AFS-8
No. of Head	Single	Two	Four	Eight
Syringes	One	Double	Four	Eight
Ampoule Sizes	1 ml to 30 ml	1 ml to 30 ml	1 ml to 10 ml	1 ml to 20 ml
Filling Speed	Up to 25 ampoules/minute	Up to 50 ampoules/minute	Up to 100 ampoules/minute	Up to 200 ampoules/minute
Filling Precision	± 1%	± 1%	± 1%	± 1%
Filling Pump	Piston Pump	Piston Pump	Piston Pump	Piston Pump
Burner Gas	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)
Nitrogen Arrangement	Before & After Filling	Before & After Filling	Before & After Filling	Before & After Filling
Number of Fill Nozzles	One	Two	Four	Eight
Number of Nitrogen Nozzles	Two	Four	Eight	Sixteen
Number of Sealing Burners	Two	Four	Eight	Sixteen
Power Required	0.5 H.P.	1 H.P.	1 H.P.	2 H.P.
Power Voltage	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L
Overall Dimension	915mm (L) x 610mm (W) x 965mm (H) approx.	915mm (L) x 760mm (W) x 965mm (H) approx.	1200mm (L) x 1070mm (W) x 965mm (H) approx.	2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of 2ml Ampoule Filler

High accuracy in filling and sealing, ensuring product safety and sterility.

Fast changeover between ampoule sizes, enhancing production flexibility.

Compact, monobloc design saves space and simplifies operation.

Compliance with GMP and CE standards, suitable for regulated industries.

Low maintenance and robust construction for long-term reliability.

Key Features of 2ml Ampoule Filler

Capacity and Output: Suitable for filling 2ml ampoules (open or closed types) with a filling range typically from 0.5ml to 2ml in a single dose. Production capacity varies by model, ranging from 1,500 to 4,500 ampoules per hour for smaller-scale machines (e.g., single or double-head fillers) to 12,000+ ampoules per hour for high-speed models (e.g., four or eight-head fillers).Filling Mechanism: Utilizes precise filling systems such as peristaltic pumps, servo-driven pumps, or piston pumps to ensure accurate dosing with minimal wastage. Some models feature a “no ampoule, no fill” function to reduce product loss.

Sealing Process: Employs a high-precision sealing system using oxygen and LPG (propane) flames. The process includes pre-heating and sealing stations, where ampoule necks are heated, rotated by specially designed rollers for uniform sealing, and sealed airtight to ensure sterility and prevent contamination.

Nitrogen Purging: Incorporates pre- and post-filling nitrogen flushing to displace atmospheric air, minimizing oxidation and ensuring product stability, especially for sensitive pharmaceuticals.

Construction: Built with high-grade stainless steel (SS 316L for contact parts and SS 304 for non-contact parts) for durability, corrosion resistance, and compliance with cGMP standards. The design often includes a monobloc structure, combining filling and sealing on a single platform for efficiency.

Operation: Features a user-friendly touchscreen interface or PLC (Programmable Logic Controller) system for easy control of filling volume, sealing temperature, and speed. Some models include automatic stop functions to prevent errors and reduce wastage.

Ampoule Handling: Ampoules are loaded via a hopper, transferred through a starwheel or cassette to a slant-travel rack for processing. The slant-travel mechanism accommodates variations in ampoule neck dimensions and thicknesses, ensuring precise centering during filling and sealing.

Customization: Adjustable trays and change parts allow compatibility with ampoule sizes from 1ml to 30ml, though optimized for 2ml. Options for safety cabinets, laminar airflow, or isolator systems are available for enhanced sterility.

Maintenance and Cleaning: Designed for easy maintenance with large bottom openings for thorough cleaning. Flow meters regulate flame intensity, and efficient cooling systems prevent overheating, extending machine lifespan.

FAQ for 2ml Ampoule Filler

What is a 2ml Ampoule Filler?

A 2ml Ampoule Filler is a high-precision automatic monobloc machine designed for filling and flame sealing sterile liquid injectables into 2ml glass ampoules. It integrates nitrogen flushing (pre- and post-filling), accurate volumetric piston filling, neck pre-heating, and LPG + Oxygen flame sealing in one compact unit. This machine is widely used in pharmaceutical production for small-volume parenterals and complies with cGMP, USFDA, WHO, and international standards.

What is the production capacity of the 2ml Ampoule Filler?

The 2ml Ampoule Filler is available in multiple head configurations:

Single Head: Up to 25 ampoules per minute (~1,500 per hour)
Two Heads: Up to 50 ampoules per minute (~3,000 per hour)
Four Heads: Up to 100 ampoules per minute (~6,000 per hour)
Eight Heads: Up to 200 ampoules per minute (~12,000 per hour)

Higher custom models can reach up to 36,000 ampoules per hour. It delivers filling accuracy of ±1% for 2ml ampoules.

Can the 2ml Ampoule Filler handle only 2ml ampoules or other sizes as well?

While optimized for 2ml ampoules, the machine is versatile and can handle ampoule sizes from 1ml to 5ml (and up to 30ml depending on the model and change parts). Quick tool-less changeover allows easy switching between different sizes, making it highly flexible for pharmaceutical manufacturers producing multiple small-volume injectable products.

What are the key features of the 2ml Ampoule Filler?

Key features include:

Optimized for accurate filling of 2ml ampoules
Nitrogen flushing before, during, and after filling to prevent oxidation
Precision piston pumps with neck centering
Slant traveling principle for gentle handling and reduced glass breakage
Tool-less quick changeover system
All product contact parts made of SS 316L
Pre-heating station and precise flame control
“No Ampoule – No Fill/Seal” safety system
Compact monobloc design with easy cleaning and maintenance

What are the main benefits of the 2ml Ampoule Filler?

Main benefits include:

Excellent filling accuracy (±1%) specifically for 2ml volume with minimal wastage
High sterility assurance through nitrogen flushing and automation
Gentle handling that reduces glass particle generation and breakage
Fast format changeover for different ampoule sizes
Compact footprint suitable for cleanroom environments
High production output with low maintenance
Full cGMP compliance and easy validation for regulated markets

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