Single Syringe Vial Filler

Q: What is a Single Syringe Vial Filler?

A Single Syringe Vial Filler is a compact, fully automatic monoblock machine designed for precise aseptic filling of sterile injectable liquids into glass or plastic vials. Also known as the VFCS 20 model or Single Head Vial Filler, it integrates liquid filling with rubber stoppering on a single platform. It is ideal for low-volume production, R&D labs, pilot batches, clinical trials, and small-scale manufacturing in the pharmaceutical, biotech, veterinary, and cosmetic industries. The machine handles vaccines, antibiotics, biologics, suspensions, and other sterile liquids with high accuracy while maintaining sterility under laminar airflow.

Q: What is the filling accuracy and how does the Single Syringe Vial Filler work?

The machine delivers excellent filling accuracy of ±1% , depending on liquid characteristics and vial size. Working Principle : Pre-sterilized vials are fed via an in-feed turntable or unscrambler onto a stainless steel slat conveyor. Vials are precisely positioned under the single syringe filling head. Liquid is dosed using a piston or peristaltic pump system with diving nozzles to minimize foaming and splashing. Filled vials immediately move to the integrated rubber stoppering station, where stoppers are inserted via a vibratory bowl and spring-loaded rollers. A “No Vial – No Filling” system prevents product wastage. Speed is controlled via variable AC frequency drive.

Description

Single Syringe Vial Filler is a specialized piece of equipment or a manual process used in pharmaceutical, laboratory, or medical settings to accurately dispense and fill a single vial with liquid medication, solution, or substance using one syringe. This is commonly applied in small-batch production, clinical trials, research, or patient self-administration scenarios where precision, sterility, and minimal waste are critical. Unlike automated multi-syringe systems designed for high-volume manufacturing, a single syringe approach prioritizes flexibility for low-volume or one-off fillings, often integrating with benchtop or semi-automatic machines.

Pharma and Biotech: Ideal for filling vials with APIs, vaccines, or biologics in R&D/clinical phases, reducing overfill waste compared to multi-dose vials.

Medical Use: Enables safe home or clinic preparation of single-dose injections, improving patient convenience over traditional vial-to-syringe draws.

If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Salient Features of Single Syringe Vial Filler

Small footprint cGMP complied machine.
Filling accuracy of ±1% depends upon liquid characteristics & vial size.
No cross contamination.
All Contact Parts Made from Stainless Steel 316L & framework by Stainless Steel 304.
Variable A.C. frequency drive for speed adjustment.
2ml to 250ml fill dosage in one machine.

Digital Vial Counter for counting production output.
In-feed Turn Table/ Unscrambler for automatic feeding of objects.
On-line Mechanism., “No Vial – No Filling” System.
Easy to validate filling system for small/large batch production.
IQ/OQ documentation can be provided.
PLC system with Graphical User Interface. (Optional)

Working Principle of Single Syringe Vial Filler

Our Vial Filling Machines comprise of a stainless steel slat conveyor and vials are transferred using this conveyor. Once the vials reach the filling station from the conveyor, the next phase of operation begins. Filling station is equipped with a number of heads for quicker operations. Here precise filling of vials takes place and they are now moved for the stoppering process. This is a very crucial part of the entire process as this ensures the vials remain immaculate and the product inside the vials also remains preserved. Pharmaceutical products must always remain free of external contaminants and other factors. The medicinal value may get compromised otherwise and hence Vial Filling and Capping Machines are indispensable to the pharmaceutical industry.

Technical Specification of Single Syringe Vial Filler

Model	VFCS 20
Production Output	Up to 20 vials/minute
Vial Size	2ml to 100ml
Filling Accuracy	±1% to the filling volume
Power Load	1 H. P.
Overall Dimension	1700mm (L) x 900mm (W) x 1700mm (H) approx.
Net Weight	300 kgs. approx.
Gross Weight	450 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Automatic Vial Filling Machine

High Speed Vial Filling Machine

Vial Liquid Filling Machine

Vial Powder Filling Machine

Automatic Vial Filling and Rubber Stoppering Machine

Lab Scale Vial Filling Stoppering & Cap Sealing Machine

Injectable Vial Powder Filling & Stoppering Machine

Peristaltic Pump based Vial Filling Machine

Applications of Vial Filling Machine

Advantages of Single Syringe Vial Filler

High precision and low shear for sensitive fluids.

Cost-effective for low volumes; quick changeovers.

Enhances yield by minimizing dead volume in the syringe needle.

Key Components of Single Syringe Vial Filler

Syringe Mechanism: Employs a single syringe equipped with a needle or spike for drawing and injecting fluid. Peristaltic or rotary piston pumps may be integrated for controlled dispensing, ensuring accuracy within ±1% volume tolerance.

Vial Compatibility: Designed for pre-sterilized vials, often ready-to-use (RTU) formats. Includes vacuum-assisted stoppering to prevent contamination and maintain seal integrity.

Sterility and Safety: Features single-use fluid paths, alcohol wipe compatibility for vial septums, and needle-free adapters to reduce needlestick risks. Systems like vented vial adapters allow air displacement without bubbles.

Operation Mode: Manual for simple draws or semi-automatic for repeatable fills. In manual mode, air is injected into the vial first to equalize pressure, followed by drawing the exact dose.

FAQ for Single Syringe Vial Filler

What is a Single Syringe Vial Filler?

A Single Syringe Vial Filler is a compact, fully automatic monoblock machine designed for precise aseptic filling of sterile injectable liquids into glass or plastic vials. Also known as the VFCS 20 model or Single Head Vial Filler, it integrates liquid filling with rubber stoppering on a single platform.

It is ideal for low-volume production, R&D labs, pilot batches, clinical trials, and small-scale manufacturing in the pharmaceutical, biotech, veterinary, and cosmetic industries. The machine handles vaccines, antibiotics, biologics, suspensions, and other sterile liquids with high accuracy while maintaining sterility under laminar airflow.

What is the production capacity and suitable vial sizes for the Single Syringe Vial Filler?

The Single Syringe Vial Filler (Model: VFCS 20) has a production output of up to 20 vials per minute.

It handles vial sizes from 2ml to 100ml (compatible up to 250ml in some configurations) and fill volumes from 2ml to 250ml in a single machine setup. This makes it highly suitable for flexible, small-batch production where high-speed multi-head machines are not required.

What is the filling accuracy and how does the Single Syringe Vial Filler work?

The machine delivers excellent filling accuracy of ±1%, depending on liquid characteristics and vial size.

Working Principle: Pre-sterilized vials are fed via an in-feed turntable or unscrambler onto a stainless steel slat conveyor. Vials are precisely positioned under the single syringe filling head. Liquid is dosed using a piston or peristaltic pump system with diving nozzles to minimize foaming and splashing. Filled vials immediately move to the integrated rubber stoppering station, where stoppers are inserted via a vibratory bowl and spring-loaded rollers. A “No Vial – No Filling” system prevents product wastage. Speed is controlled via variable AC frequency drive.

What are the key features and construction of the Single Syringe Vial Filler?

Key features include:

Compact small-footprint cGMP-compliant monoblock design
All product contact parts made of AISI SS 316L; framework in SS 304
“No Vial – No Filling” mechanism to avoid wastage
Variable AC frequency drive for adjustable speed
Digital vial counter for production monitoring
In-feed turntable/unscrambler for automatic vial feeding
Optional PLC + HMI with Graphical User Interface and IQ/OQ documentation
Easy cleaning, no cross-contamination, and quick format changeover

The machine has a power load of 1 HP and approximate dimensions of 1700mm (L) × 900mm (W) × 1700mm (H) with a net weight of 300 kg.

What are the main advantages of using a Single Syringe Vial Filler?

The main advantages include:

Perfect for R&D, pilot-scale, and small-batch production with low investment cost
High filling accuracy (±1%) and minimal product wastage
Compact design saves valuable cleanroom space
Reduced labor costs and human error through automation
Easy validation and quick changeover for different vial sizes and volumes
Full cGMP compliance with support for sterile injectable manufacturing
Flexible standalone use or integration into complete lines (washing → sterilization → filling → stoppering → capping)
Cost-effective and reliable solution for laboratories needing precision without high-speed requirements

Countries We Export to

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

GET A QUOTE!