Eight Syringe Vial Filling Machine

Q: How does the machine ensure accuracy and hygiene?

The machine offers a filling accuracy of +/- 1% . To maintain strict hygiene and prevent product loss, it features a 'No Vial - No Filling' system . This sensor-based technology ensures that the syringes only dispense liquid when a vial is correctly positioned under the needles, keeping the conveyor and machine bed clean.

Q: Can this machine handle both filling and stoppering?

Yes, most Eight Syringe models are built as Filling and Stoppering machines . After the eight needles dispense the liquid, the vials move immediately to the stoppering station where rubber stoppers (either 13mm or 20mm) are automatically picked and placed, ensuring the product is sealed immediately after filling to minimize contamination risk.

Description

Eight Syringe Vial Filling Machine is an advanced, Automatic Pharmaceutical Filling and Stoppering System designed for high-precision liquid filling of injectable vials. It utilizes eight stainless steel syringes for volumetric dispensing, making it ideal for medium-batch production in sterile environments. This machine ensures compliance with cGMP standards, minimizes product variation, and supports efficient operation without frequent change parts for different vial sizes or fill volumes.

Infeed: Sterilized and siliconized vials are fed via an in-feed turntable and guided onto a stainless steel slat conveyor belt.

Positioning: Vials are indexed by a star wheel under the eight filling nozzles for precise centering.

Filling: Nozzles descend via cam mechanism for nitrogen pre-purge, followed by liquid filling as the nozzles ascend. Liquid is drawn from a reservoir through transparent silicone tubing.

Stoppering: Filled vials are transferred to a rubber stoppering station, where vacuum or mechanical stoppers are placed and seated.

Outfeed: Completed vials exit via conveyor for capping or further packaging.

The process is continuous and synchronized, with each of the eight heads operating independently for uninterrupted production.

If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Salient Features of Eight Syringe Vial Filling Machine

Piston pump/Peristaltic pump aseptic filling.
Filling accuracy of ±0.5% to ±1%.
No cross contamination.
All Contact Parts Made from Stainless Steel 316L & framework by Stainless Steel 304.
Variable A.C. frequency drive for speed adjustment.
Suitable for the filling Volume of 2ml to 250ml.

Digital Vial Counter for counting production output.
“No Vial – Machine Stop” System.
On-line Mechanism., “No Vial – No Filling” System.
Easy to validate filling system for small/large batch production.
IQ/OQ documentation can be provided.
PLC system with Graphical User Interface. (Optional)

Working Principle of Eight Syringe Vial Filling Machine

The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.

The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.

Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.

Technical Specification of Eight Syringe Vial Filling Machine

Model	ALVF-120
Filling Heads	Eight
Production Rate	Up to 150 Vials/Minute
Vial Diameter	15mm to 70mm
Vial Height	25mm to 140mm
Filling Precision	±1%
Power Required	2 H.P.
Electrical Characteristics	440 Volts, 3 Phase, 50 Hertz
Overall Dimension	3000mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Automatic Vial Filling Machine

High Speed Vial Filling Machine

Vial Liquid Filling Machine

Vial Powder Filling Machine

Automatic Vial Filling and Rubber Stoppering Machine

Lab Scale Vial Filling Stoppering & Cap Sealing Machine

Injectable Vial Powder Filling & Stoppering Machine

Peristaltic Pump based Vial Filling Machine

Applications of Vial Filling Machine

Advantages of Eight Syringe Vial Filling Machine

High Production Throughput

High Dosing Accuracy

Integrated "No Vial – No Filling" System

cGMP Compliance and Sterility

Multi-Stage Synchronization

Key Components of Eight Syringe Vial Filling Machine

Filling Mechanism: Equipped with eight independent SS 316L syringes and nozzles for accurate liquid dosing. Syringes feature non-return valves to prevent volume variations during suction and delivery. Nitrogen purging (pre- and post-gassing) is integrated to maintain sterility and prevent oxidation.

No Vial-No Fill Sensor: Automatically detects empty vial positions to avoid wastage and ensure safety.

Construction: Made from high-grade stainless steel (SS 316L) for corrosion resistance and easy cleaning. Includes eccentric blocks, cam-driven nozzle movement, and synthetic rubber tubing for durability and low maintenance.

Sterility Compliance: Operates in a controlled environment with laminar airflow compatibility; suitable for Grade A cleanrooms.

Flexibility: Adjustable stroke length on pistons allows for varying fill volumes. No mechanical change parts needed for most vial sizes.

FAQ for Eight Syringe Vial Filling Machine

What is the output capacity of the Eight Syringe Vial Filling Machine?

The Eight Syringe (Eight Head) model is designed for high-speed efficiency, capable of filling 120 to 150 vials per minute. The actual output depends on factors such as the vial diameter, the fluid’s viscosity, and the specific fill volume required for your production run.

What filling range can this machine accommodate?

This machine is highly versatile and can handle a wide range of fill volumes, typically from 2 ml to 250 ml. The volume is easily adjustable, and the machine utilizes eight high-precision Stainless Steel 316L volumetric syringes to ensure consistent dosage.

How does the machine ensure accuracy and hygiene?

The machine offers a filling accuracy of +/- 1%. To maintain strict hygiene and prevent product loss, it features a “No Vial – No Filling” system. This sensor-based technology ensures that the syringes only dispense liquid when a vial is correctly positioned under the needles, keeping the conveyor and machine bed clean.

What materials are used to ensure cGMP compliance?

To meet international pharmaceutical standards (cGMP), all contact parts, including the syringes, nozzles, and delivery tubes, are made from AISI SS 316L. The non-contact parts and the main structure are made from AISI SS 304 with a matte finish to allow for easy sterilization and durability in a cleanroom environment.

Can this machine handle both filling and stoppering?

Yes, most Eight Syringe models are built as Filling and Stoppering machines. After the eight needles dispense the liquid, the vials move immediately to the stoppering station where rubber stoppers (either 13mm or 20mm) are automatically picked and placed, ensuring the product is sealed immediately after filling to minimize contamination risk.

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