The Eight Syringe Vial Filling Machine is an advanced, automatic pharmaceutical filling and stoppering system designed for high-precision liquid filling of injectable vials. It utilizes eight stainless steel syringes for volumetric dispensing, making it ideal for medium-batch production in sterile environments. This machine ensures compliance with cGMP standards, minimizes product variation, and supports efficient operation without frequent change parts for different vial sizes or fill volumes.
Eight Syringe Vial Filling Machine Video
Key Features
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Filling Mechanism: Equipped with eight independent SS 316L syringes and nozzles for accurate liquid dosing. Syringes feature non-return valves to prevent volume variations during suction and delivery. Nitrogen purging (pre- and post-gassing) is integrated to maintain sterility and prevent oxidation.
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No Vial-No Fill Sensor: Automatically detects empty vial positions to avoid wastage and ensure safety.
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Construction: Made from high-grade stainless steel (SS 316L) for corrosion resistance and easy cleaning. Includes eccentric blocks, cam-driven nozzle movement, and synthetic rubber tubing for durability and low maintenance.
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Sterility Compliance: Operates in a controlled environment with laminar airflow compatibility; suitable for Grade A cleanrooms.
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Flexibility: Adjustable stroke length on pistons allows for varying fill volumes. No mechanical change parts needed for most vial sizes.
Operation Process
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Infeed: Sterilized and siliconized vials are fed via an in-feed turntable and guided onto a stainless steel slat conveyor belt.
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Positioning: Vials are indexed by a star wheel under the eight filling nozzles for precise centering.
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Filling: Nozzles descend via cam mechanism for nitrogen pre-purge, followed by liquid filling as the nozzles ascend. Liquid is drawn from a reservoir through transparent silicone tubing.
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Stoppering: Filled vials are transferred to a rubber stoppering station, where vacuum or mechanical stoppers are placed and seated.
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Outfeed: Completed vials exit via conveyor for capping or further packaging.
The process is continuous and synchronized, with each of the eight heads operating independently for uninterrupted production.
Applications
Primarily used in the pharmaceutical industry for filling injectable liquids such as vaccines, antibiotics, and biologics into vials. It’s scalable for R&D, clinical trials, and commercial production, with options for integration into larger lines. Manufacturers like Adinath offer customizable models for specific batch sizes.
Salient Features of Vial Filling Machine
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Suitable for the filling Volume of 2ml to 250ml.
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Piston pump/Peristaltic pump aseptic filling.
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Filling accuracy of ±0.5% to ±1%.
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No cross contamination.
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Easy to validate filling system for small/large batch production.
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All Contact Parts Made from Stainless Steel 316L & framework by Stainless Steel 304.
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Variable A.C. frequency drive for speed adjustment.
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Digital Vial Counter for counting production output.
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In-feed Turn Table/ Unscrambler for automatic feeding of objects.
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On-line Mechanism.
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“No Vial – No Filling” System.
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“No Vial – Machine Stop” System.
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IQ/OQ documentation can be provided.
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PLC system with Graphical User Interface. (Optional)
Process Operation of Automatic Vial Filler
The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.
The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.
Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.
Technical Specification of Eight Syringe Vial Filling Machine
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Model |
ALVF-120 |
| Filling Heads |
Eight |
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Production Rate |
Up to 150 Vials/Minute |
| Vial Diameter |
15mm to 70mm |
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Vial Height |
25mm to 140mm |
| Filling Precision |
±1% |
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Power Required |
2 H.P. |
| Electrical Characteristics |
440 Volts, 3 Phase, 50 Hertz |
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Overall Dimension |
3000mm (L) x 945mm (W) x 1700mm (H) |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
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