Compact Ampoule Filler

A compact ampoule filler is a specialized pharmaceutical machine designed for precise filling and sealing of glass ampoules, typically used for injectable liquids, vaccines, or other sterile solutions. Below is a concise description of a compact ampoule filler, based on common features and industry standards, with reference to the provided context where applicable:

Compact Ampoule Filler Video

Description of a Compact Ampoule Filler

• Purpose: Fills and seals glass ampoules (open or closed types) with liquid or powder in pharmaceutical, biotech, cosmetic, or chemical industries.

• Design:

  • Compact cGMP Model: Space-efficient, adhering to Current Good Manufacturing Practices (cGMP) for sterile environments.

  • Monobloc Construction: Integrates filling, sealing, and sometimes nitrogen purging in a single unit, reducing contamination risks.

  • Material: Contact parts made of AISI SS 316L for GMP compliance; non-contact parts typically AISI SS 304.

• Capacity:

  • Fills ampoules from 0.5ml to 30ml in single dosing.

  • Output ranges from 15 to 150 ampoules per minute, depending on model (e.g., single-head to eight-head configurations).

• Operation:

  • Filling Mechanism: Utilizes piston pumps, servo-driven systems, or peristaltic pumps for high accuracy (±0.5% fill precision).

  • Process: Ampoules are loaded via an infeed hopper, transported via starwheel or rack, and undergo pre-gassing (nitrogen), filling, post-gassing, pre-heating, and sealing.

  • Sealing: Uses oxygen and LPG (propane) for flame sealing, with safety valves and exhaust systems.

  • Automation: Features PLC-based controls with HMI (Human-Machine Interface) for easy operation and volume adjustments.

• Features:

  • No Ampoule, No Fill: Prevents liquid wastage.

  • Nitrogen Flushing: Before and after filling to minimize contamination.

  • Quick Changeover: Minimal parts change for different ampoule sizes (1ml to 30ml).

  • Accessibility: Designed for easy maintenance and cleaning, with large bottom openings or ergonomic geometry.

  • Optional Features: Laminar Air Flow, safety cabinets, or isolators for enhanced sterility; check-weighing systems for quality control.

  • Applications: Ideal for small to medium-scale production, R&D, or lab-scale operations, handling aqueous solutions, powders, or pellets.

  • Power: Adjustable voltage (e.g., 230V, single-phase, 50Hz) to suit local requirements.

Key Advantages

• High precision and sterile operation ensure product safety.

• Compact footprint suits space-constrained facilities.

• Versatile for various ampoule sizes and types (open or pre-sterilized closed ampoules).

• Easy integration with upstream (e.g., sterilization tunnels) and downstream (e.g., labeling) equipment.

Types of Ampoule Fillers

• Small Ampoule Filler
• Ampoule Filler and Sealer
• Onion Skin Ampoule Filler
• Servo Driven Ampoule Filler
• Peristaltic Pump type Ampoule Filler
• Closed Ampoule Filler
• Single Head Ampoule Filler
• Two Head Ampoule Filler
• Four Head Ampoule Filler
• Six Head Ampoule Filler
• Eight Head Ampoule Filler

Salient Features of Compact Ampoule Filler

• Compact model as per cGMP standard.

• Higher production output up to 12000 Ampoules per hour.

• All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.

• Minimum change over parts from 1ml to 10ml ampoule size.

• “No Ampoule – No Filling” system.

• Ampoule neck centering during gas flushing and filling operations.

• Possibility of nitrogen gas flushing before, during and after filling.

• Full accessibility allows easy maintenance.

• Machine equipped with pre-warming station.

• Flow Meters for regulating flames easily.

• Minimum change over time, little maintenance, easy cleaning.

Process Operation of Compact Ampoule Filler

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect one/two/four/eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. For detailed working process please explore automatic ampoule filler video in top right section of this page.

Technical Specification of Ampoule Filler Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.