Eight Head Ampoule Filling Machine

The Eight Head Ampoule Filling Machine is a high-speed, advanced piece of pharmaceutical equipment designed for precise filling and sealing of glass ampoules, primarily used in sterile pharmaceutical, biotech, cosmetic, veterinary, and chemical industries. Below is a detailed description based on industry standards and available information:

Eight Head Ampoule Filling Machine Video

Key Features and Description:

1. High-Speed Production:

   • Capable of filling and sealing up to 12,000 ampoules per hour (approximately 80–280 ampoules per minute, depending on ampoule size and liquid viscosity). For example, it can process up to 290 ampoules/min for 1ml ampoules, 270 for 2ml, 260 for 3ml, 240 for 5ml, and 150 for 10ml.

   • Ideal for medium to large-scale production lines requiring high output with minimal errors.

2. Filling and Sealing Mechanism:

   • Filling Capacity: Handles ampoule sizes from 0.5ml to 25ml in a single dose, with precise volume control. Common models support 1ml to 10ml ampoules, with some offering flexibility up to 20ml.

   • Filling Options: Equipped with multiple filling mechanisms, including:

     • Piston Pump Filling: Ensures consistent dosing for various liquids.

     • Servo-Driven Filling: Enhances accuracy with programmable control.

     • Peristaltic Pump Filling: Ideal for sterile operations, minimizing contamination.

   • Two-Stage Sealing Process:

     • Preheating: Removes residual droplets to ensure clean sealing.

     • Sealing: Uses LPG and oxygen with clippers for precise, defect-free seals.

   • Nitrogen Flushing: Pre- and post-filling nitrogen purging to maintain sterility and prevent contamination.

3. Construction and Compliance:

   • Built on a stainless steel square pipe frame with SS 316L contact parts for injectable liquids, ensuring compliance with cGMP standards. Non-contact parts are typically made of SS 304.

   • GMP Compliance: Designed for sterility, with contact surfaces ensuring hygiene for injectable liquids.

   • Robust Design: Heavy-duty stainless steel piping and anti-rust treatment for durability and jerk-free operation.

   • Easy Maintenance: Features a large bottom opening for cleaning and quick-changeover parts to minimize downtime when switching ampoule sizes (1ml to 10ml).

4. Operational Efficiency:

   • Slant Travel Mechanism: Ampoules move in an inclined position through filling and sealing stations, accommodating variations in neck dimensions and thicknesses.

   • No Ampoule, No Fill System: Prevents liquid wastage by halting filling when no ampoule is detected.

   • Neck Centering: Ensures precise alignment during filling, gas flushing, and sealing for improved accuracy.

   • Automated Process: Sterilized ampoules are loaded into a slant hopper, delivered via a synchronized star wheel to an eccentric rack, and processed through pre-gassing, filling, post-gassing, preheating, and sealing stations. Filled ampoules are collected automatically without manual handling.

5. Advanced Features:

   • PLC-Based Control: Some models include a PLC with an HMI touch screen for automatic fill volume adjustments, reducing manual intervention.

   • Servo-Based Vertical Models: High-speed vertical fillers with 8, 12, or 16 nozzles for enhanced precision.

   • Pre-Warming Unit: Ensures proper heating of ampoule necks for flawless sealing, especially for thicker glass.

   • Gas Flow Meters: Acrylic body meters for easy flame setting (oxygen and LPG).

   • Optional Features:

     • Safety cabinet with doors and Class 100 laminar airflow for sterile filling.

     • Compatibility with both open-mouth and closed-mouth (Type B and C) ampoules.

     • Dead tray for upright collection of filled ampoules and waste tip collector for easy disposal.

     • CE and ISO 9001:2000 certifications for quality assurance.

6. Applications:

   • Suitable for filling and sealing ampoules with injectable liquids, agro-insecticides, veterinary medicines, cosmetics, and chemicals.

   • Can be used standalone or integrated into a complete ampoule filling line with washing, sterilization, inspection, and labeling machines.

7. Technical Specifications (based on common models like Adinath AFS-200 or Harsiddh HFS-300V):

   • Output: 80–280 ampoules/min (up to 17,000/hour, depending on size).

   • Filling Heads: 8 nozzles for simultaneous filling.

   • Sealing: Uses LPG and oxygen with a two-stage process.

   • Power Requirements: Adjustable voltage per customer needs.

   • Ampoule Handling: Processes 1ml to 10ml open-mouth glass ampoules; some models support up to 20ml or closed-mouth ampoules.

   • Dimensions: Compact, monoblock design with filler and sealer on a single platform.

8. Advantages:

   • High Precision: Minimal breakage and accurate dosing for high reliability.

   • Low Maintenance: Quick-change parts and easy cleaning reduce operational costs.

   • Versatility: Handles a wide range of ampoule sizes and liquid types with customizable filling options.

   • Sterility: Nitrogen flushing and GMP-compliant materials ensure product safety.

   • Global Reach: Machines are exported to over 48 countries, with manufacturers like Adinath International offering tailored solutions.

Process Operation:

1. Sterilized ampoules are loaded into the slant hopper.

2. A synchronized star wheel delivers ampoules (in groups of eight) to a moving eccentric rack.

3. Ampoules move through stations for:

   • Pre-Nitrogen Flushing: Inert gas to maintain sterility.

   • Filling: Precise liquid dosing via chosen pump mechanism.

   • Post-Nitrogen Flushing: Additional gas flush to prevent contamination.

   • Preheating: Warms ampoule necks for sealing.

   • Sealing: Uses LPG/oxygen for a clean, secure seal.

4. Filled and sealed ampoules are automatically collected in an upright position on a tray, with waste tips ejected into a separate container.

Salient Features of Eight Head Ampoule Filling Machine

• Compact cGMP model.

• Higher output up to 12000 Ampoules per hour.

• All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.

• Minimum change over parts from 1ml to 10ml ampoule size.

• “No Ampoule – No Filling” system.

• Ampoule neck centering during gas flushing and filling operations.

• Possibility of nitrogen gas flushing before, during and after filling.

• Full accessibility allows easy maintenance.

• Machine equipped with pre-warming station.

• Flow Meters for regulating flames easily.

• Minimum change over time, little maintenance, easy cleaning.

Process Operation of Eight Head Ampoule Filler

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Technical Specification of Eight Head Ampoule Filling Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.