Onion Skin Ampoule Filling Machine

We offer four standard models:

• AFS-1 (Single Head): Up to 25 ampoules per minute (~1,500 per hour)
• AFS-2 (Two Heads): Up to 50 ampoules per minute
• AFS-4 (Four Heads): Up to 100 ampoules per minute (~6,000 per hour)
• AFS-8 (Eight Heads): Up to 200 ampoules per minute (~12,000 per hour)

Higher custom models can reach up to 36,000 ampoules per hour. It supports ampoule sizes from 1ml to 30ml (model dependent), with filling range 0.5ml to 25ml (or smaller volumes down to 0.1ml in special configurations) and filling accuracy of ±1%.

The machine uses the slant traveling principle along with neck centering and ampoule rotation to gently handle fragile onion skin ampoules and reduce breakage. Key adaptations include:

• Specially designed burners for thin glass
• Pre-warming station for uniform heating
• Nitrogen flushing before, during, and after filling
• Precise neck centering during flushing and filling

Sterilized ampoules move through synchronized star wheels for pre-gassing, filling with piston pumps, post-gassing, pre-heating, and LPG + Oxygen flame sealing. A “No Ampoule – No Filling” system prevents wastage.

Key features include:

• All product contact parts in SS 316L and non-contact parts in SS 304
• Nitrogen flushing before, during, and after filling to prevent oxidation
• Tool-less quick changeover with minimal parts
• Slant design and neck centering to accommodate variations in thin ampoule shape and thickness
• Pre-warming station and precise flame control
• “No Ampoule – No Fill/Seal” safety system
• Compact monobloc design with easy maintenance and cleanroom compatibility
• Optional PLC/HMI with 21 CFR Part 11 compliance

These features ensure high sterility, low glass breakage, and consistent sealing quality.

It is widely used in:

• Pharmaceuticals (small-volume injectables, vaccines, and parenterals)
• Biotechnology
• Cosmetics and serums
• Veterinary medicines
• Chemical and agro-insecticide industries

Main benefits:

• Gentle handling of delicate thin-walled ampoules with reduced breakage
• High filling accuracy (±1%) and minimal product wastage
• Enhanced sterility through nitrogen flushing and automation
• Fast format changeover and low maintenance
• Compact footprint with robust cGMP, USFDA, WHO, and ISO-compliant design
• Easy integration into complete injectable production lines

Yes — Adinath International Onion Skin Ampoule Filling Machine complies to cGMP, MHRA, FDA and WHO-GMP standards, with optional CE marked equipments and 21 CFR Part 11 software compliance for the HMI/PLC. Machine contact parts having Stainless Steel 316L grade materials with validation documents having IQ, OQ, DQ validation protocols as optional. Organization is ISO 9001:2015 certified.

Manufacturing lead time is generally 7 to 14 weeks from order confirmation. Further it takes 2 to 8 weeks for international shipping depending upon destination. Order can be expediate sooner or later as per specific buying requirements. Destination specific certifications like US FDA, EU, ANVISA, SFDA. CE can add 3 to 6 weeks additionally.

Yes, Adinath International Onion Skin Ampoule Filling Machine export this machine to more than 48 countries of this world including America, Europe, Asia, Middle East, Africa, CIS and Australia sub continents. Please visit our clientele page for complete list of our customers worldwide. Located at Ahmedabad, India having world class infrastructure.

Service of skilled engineers and technicians provided for technical support of supplied equipments. Installations, commissioning, training and IQ, OQ, DQ validations performed by qualified engineers. Remote support through video call, phone, email and other modes provided for international installations. Spare parts of Onion Skin Ampoule Filling Machine stocked at our premises in Ahmedabad and shipped immediately after ordering. Standard 12 months manufacturing warranty included with supplied equipment.