Automatic Vial Powder Filling Machine

Automatic Vial Powder Filling Machine are specialized pharmaceutical equipment designed to precisely fill sterile powders into glass vials under aseptic conditions. These machines ensure compliance with cGMP standards, minimize contamination risks, and integrate processes like filling, stoppering, and capping. They are essential in the production of injectable powders, handling vial sizes from 2R to 100 ml, with speeds ranging from 100 to 450 vials per minute depending on the model.

Automatic Vial Powder Filling Machine Video

Key Features and Technologies

• Filling Mechanism: Typically uses volumetric methods like vacuum/pressure systems or auger screws for accurate dosing. Some advanced models employ 100% in-process control (IPC) weighing to avoid product loss.

• Aseptic Design: Stainless steel construction, laminar airflow integration, and compatibility with isolators or RABS for sterile environments.

• Additional Functions: Inline stoppering, capping, and optional washing/depyrogenation integration.

• Customization: Options for single/double tracks, multiple powder wheels, or hybrid liquid/powder setups.

Salient Features of Automatic Vial Powder Filling Machine

• Compact cGMP model.

• “No Vial, No Filling” system eliminates wastage of costly powder.

• Multiple Dosing System.

• High Volumetric Filling Accuracy of ±2% of uniform density Injectable powder can be ensured by setting the depth of piston in the port of powder wheel.

• Built-in Rubber Stoppering Unit saves lot of space in the Sterile Area & reduces the length of Laminar Flow.

• Individual drive for the filling & sealing to match the speed of filling & sealing.

• All motors are provided with appropriate contractors and relays for the protection against any overload or jamming.

• Safety clutch system to avoid Vial breakage.

• Variable AC Frequency Drive for speed adjustment.

• All contact parts are easily removable for mandatory Autoclaving/ Sterilization.

• Digital counter for counting production output.

Working Principle of Vial Powder Filler

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Vial Powder Filler Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.