Bottle Dry Injectable Filling Machine

A Bottle Dry Injectable Filling Machine often referred to as a Dry Powder Injectable Filling Machine is specialized pharmaceutical equipment designed for the precise filling of sterile dry powders into glass vials or bottles. These powders are typically used for injectable medications that are reconstituted with a solvent before administration. Common applications include antibiotics, vaccines, and other heat-sensitive drugs that can’t be stored as liquids. The machines ensure aseptic processing to maintain sterility, with filling accuracies often within ±2% for doses ranging from 50mg to 1,500mg.

Injectable Filling Machine are critical in cGMP-compliant environments, often integrated into cleanrooms or under laminar flow hoods. They typically combine filling with secondary operations like rubber stoppering or capping to minimize contamination risks.

Dry Injectable Filling Machine Video

Key Features and Components

Based on industry-standard models, here’s a breakdown of common features:

• Filling Mechanism: Auger or vacuum-driven powder wheels for precise dosing; supports single or multiple doses.

• Container Handling: In-feed turntable/unscrambler for vials; Delrin conveyor belts to prevent sticking.

• Stoppering/Capping: Integrated rubber stopper placement or screw capping; vibratory bowl feeders.

• Drive System: Servo motors, AC frequency drives for speed control; imported gear motors.

• Safety/Compliance: No-oil gearboxes; clutch devices on separators; isolator/RABS compatibility for aseptic barriers.

Types and Production Capacities

• Single-Head Models: Compact, semi-automatic or automatic; output: 30-60 vials/min. Ideal for small batches or R&D.

• Double-Head/Wheel Models: Higher throughput; output: 100-200 vials/min. Suited for large-scale production.

• Monobloc Systems: Combine filling, stoppering, and sometimes labeling in one unit for efficiency.

Salient Features of Bottle Dry Injectable Filling Machine

• Monoblock cGMP Model.

• “No Bottle – No Fill” System

• Rotary Bottle Movement System with Rotary Funnel System

• Funnel with Unique Vibratory system for filling semi free flow powder at higher speed.

• All contact parts with easy removal system for Cleaning / Autoclaving / Sterilization.

• Machine construction in SS304 material.

• Filling Accuracy of ±2% depending on powder at controlled humidity below 28% Rh.

• Automatic Infeed and Exit of Bottles through Star Wheel System.

• No Bottle at infeed conveyor – Automatic Machine on/off system.

• Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.

• Low Air – Machine Stop System.

• Low Vacuum – Machine Stop System.

• Toughened Glass Safety Cabinet.

Process Operation of Injectable Filling Machine

The incoming sterilized dry bottle is fed through the in-feed turn table. Suitable guide supply bottles on to flat conveyor belt at the required speed for feeding. There is filling head mounted on machine top plate in the same line. When bottle reaches to the mechanical holder detained filling station, Bottle sensor sense the bottles and Magnetic clutch starts to rotate which is mounted on auger shaft. It fills the desired amount of powder into the bottle through auger, where rotation time is previously determined. Duly filled bottles go upward on to the sealing station with the help of SS conveyor belt.

Technical Specification of Dry Injectable Filler Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.