Dry Powder Filling Machine For Glass Vials

Description

Dry Powder Filling Machine For Glass Vials are specialized equipment used primarily in the pharmaceutical industry to accurately dispense sterile dry powders into glass vials. Dry Powder Filling Machine ensure precise dosing, maintain sterility, and often integrate rubber stoppering and sealing processes in a monoblock design to comply with cGMP standards. They are essential for handling sensitive formulations that cannot be stored in liquid form, reducing energy costs compared to lyophilization processes.

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Working Principle of Dry Powder Filling Machine For Glass Vials

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Dry Powder Filling Machine For Glass Vials

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machine

Applications of Powder Filling Machine

Advantages of Dry Powder Filling Machine For Glass Vials

High Filling Accuracy and Repeatable Precision

Superior Sterility and Contamination Control

Minimal Product Wastage and Cost Savings

Enhanced Hygiene, Safety, and Easy Maintenance

Key Features of Dry Powder Filling Machine For Glass Vials

  • Dosing Mechanism: Vacuum-pressure or auger systems with servo motors for powder wheel rotation.

 

  • Stoppering Integration: Built-in rubber bung insertion, often with vibratory feeders.

 

  • Material Construction: SS 316L contact parts, explosion-proof options for volatile powders.

 

  • Safety & Controls: PLC/HMI interfaces, sensors for vial jams, and in-process weighing (IPC) for 100% quality control.

 

  • Customization: Modular designs for inline washing, sterilization tunnels, labeling, and cartoning.

FAQ for Dry Powder Filling Machine For Glass Vials

The “No Vial – No Fill” system ensures the machine only dispenses powder when a vial is properly positioned. This eliminates costly powder wastage, reduces cleaning time due to spillage, prevents cross-contamination, and improves overall yield — especially important for expensive sterile injectable powders.

Yes. The Dry Powder Filling Machine for Glass Vials is designed for seamless integration with upstream equipment (vial washing, depyrogenation tunnel) and downstream equipment (capping, labeling, inspection, and cartoning). It supports full automatic sterile vial processing lines while maintaining cGMP compliance.

All product contact parts are made of SS 316L and are easily removable for autoclaving/sterilization. The machine features tool-less adjustments, quick changeover parts for different vial sizes, and a hygienic design that allows thorough cleaning. Regular maintenance involves checking vacuum systems, agitators, and doctor blades, with low overall downtime.

Yes. While the standard models (APF 12S & APF 12D) support high outputs up to 100–200 vials per minute, the machine’s compact GMP design, multiple dosing options, and quick changeover make it suitable for pilot-scale, R&D, and commercial production. Custom lower-speed configurations are also available based on customer needs.

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Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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