

Dry Powder Filling Machine For Glass Vials are specialized equipment used primarily in the pharmaceutical industry to accurately dispense sterile dry powders into glass vials. Dry Powder Filling Machine ensure precise dosing, maintain sterility, and often integrate rubber stoppering and sealing processes in a monoblock design to comply with cGMP standards. They are essential for handling sensitive formulations that cannot be stored in liquid form, reducing energy costs compared to lyophilization processes.
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The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
Dry Powder Filling Machines for Glass Vials are designed for aseptic, sterile injectable powders (e.g., antibiotics, vaccines) with built-in rubber stoppering under Class 100 laminar airflow. In contrast, machines for glass bottles are typically used for non-sterile applications like dry syrups and use auger-based filling. Vial machines prioritize higher sterility, precision for small volumes (50 mg–10 g), and monoblock filling + stoppering, while bottle fillers focus on higher-volume fills for oral products.
The “No Vial – No Fill” system ensures the machine only dispenses powder when a vial is properly positioned. This eliminates costly powder wastage, reduces cleaning time due to spillage, prevents cross-contamination, and improves overall yield — especially important for expensive sterile injectable powders.
Yes. The Dry Powder Filling Machine for Glass Vials is designed for seamless integration with upstream equipment (vial washing, depyrogenation tunnel) and downstream equipment (capping, labeling, inspection, and cartoning). It supports full automatic sterile vial processing lines while maintaining cGMP compliance.
All product contact parts are made of SS 316L and are easily removable for autoclaving/sterilization. The machine features tool-less adjustments, quick changeover parts for different vial sizes, and a hygienic design that allows thorough cleaning. Regular maintenance involves checking vacuum systems, agitators, and doctor blades, with low overall downtime.
Yes. While the standard models (APF 12S & APF 12D) support high outputs up to 100–200 vials per minute, the machine’s compact GMP design, multiple dosing options, and quick changeover make it suitable for pilot-scale, R&D, and commercial production. Custom lower-speed configurations are also available based on customer needs.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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