High Speed Injectable Powder Filling Machine

A High Speed Injectable Powder Filling Machine is a specialized piece of pharmaceutical equipment designed for the automated filling of sterile dry powders into glass vials for injectable use. These machines ensure precise dosing, maintain sterility, and integrate rubber stoppering in a monobloc setup, complying with cGMP standards. They are essential for high-volume production in cleanroom environments, minimizing contamination risks and waste while handling sensitive formulations that can’t be stored as liquids.

Injectable Powder Filling Machine use vacuum-pressure systems or servo-driven mechanisms to suck and dispense powder accurately, often with in-process controls (IPC) for 100% quality checks. Output speeds typically range from 100 to 450 vials per minute (VPM), depending on the model and configuration.

High Speed Injectable Powder Filling Machine Video

Key Features

• Precision Dosing: Filling accuracy of ±1-2%, achieved via adjustable pistons, doctor blades, and vacuum ports.

• Sterile Operation: All contact parts made from SS316L stainless steel; optional laminar airflow and containment for aseptic filling.

• Automation: User-friendly interfaces, servo motors for variable dosing, and built-in turntables for smooth vial infeed/outfeed.

• Versatility: Supports multiple vial sizes, change parts for different fill volumes, and integration with washing, sealing, or labeling lines.

• Safety & Efficiency: Vibratory rubber stoppering synchronized with filling speed; rejection systems for under/over-filled vials; compact designs to save cleanroom space.

How It Works

1. Vial Feeding: Vials enter via turntable and are oriented upright.

2. Powder Handling: Sterile powder from a hopper is agitated for uniform density, then vacuum-sucked into rotating powder wheel ports.

3. Filling: Precise powder volume is released into vials; excess is doctored off. Servo or vacuum systems adjust for speed.

4. Stoppering: Rubber stoppers are vibrated and inserted inline.

5. Output: Filled/stoppered vials exit for capping or further processing. IPC weighing ensures consistency, rejecting defects.

Applications

• Primary Use: Filling sterile powders for injectables in vials.

• Industries: Pharmaceuticals, biotech, and nutraceuticals.

• Benefits: Boosts throughput, reduces labor, ensures regulatory compliance, and supports lyophilization prep.

Salient Features of Injectable Powder Filling Machine

• Compact cGMP model.

• “No Vial, No Filling” system eliminates wastage of costly powder.

• Multiple Dosing System.

• High Volumetric Filling Accuracy of ± 1% of uniform density Injectable powder can be ensured by setting the depth of piston in the port of powder wheel.

• Built-in Rubber Stoppering Unit saves lot of space in the Sterile Area & reduces the length of Laminar Flow.

• Individual drive for the filling & sealing to match the speed of filling & sealing.

• All motors are provided with appropriate contractors and relays for the protection against any overload or jamming.

• Safety clutch system to avoid Vial breakage.

• Variable AC Frequency Drive for speed adjustment.

• All contact parts are easily removable for mandatory Autoclaving/ Sterilization.

• Digital counter for counting production output.

Process Operation of Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Injectable Powder Filling Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.