An Aseptic Washing Machine (also known as an aseptic vial washer, aseptic bottle washer, or sterile washing machine) is a specialized piece of pharmaceutical equipment designed to clean and decontaminate vials, ampoules, syringes, bottles, or other primary packaging components under strictly aseptic (sterile) conditions before they enter the sterile filling process.
Aseptic Washing Machine Video
Key Features and Purpose
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Primary Goal: Remove particulate matter, pyrogens, endotoxins, and microbial contamination from containers while maintaining a sterile environment (typically ISO 5 / Class 100 or better).
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Used in sterile injectable manufacturing (vials, pre-filled syringes, cartridges, ampoules, etc.).
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Ensures the containers are clean and pyrogen-free before sterilization (usually by depyrogenation tunnel or autoclave) and aseptic filling.
How It Works
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Loading: Containers are loaded (manually or automatically) into the machine.
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Pre-cleaning: External cleaning with purified water or air.
- Internal Washing Cycles:
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Recirculated WFI (Water for Injection) sprays
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Fresh WFI rinsing
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Clean compressed air or nitrogen blowing to remove water droplets
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Silicone oil application (for syringes, if needed)
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Sterile Environment: Entire washing zone is under laminar flow (HEPA-filtered air) and surrounded by isolator or RABS to prevent recontamination.
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Discharge: Clean, sterile, and dry containers are directly transferred (via conveyor or robotic arm) into the depyrogenation tunnel or filling line without exposure to the outside environment.
Critical Design Aspects
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Made of 316L stainless steel (mirror-polished, <0.4 μm Ra) for easy cleaning and sterilization.
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Uses WFI at 60–80°C for washing and pyrogen removal.
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No dead legs, fully drainable, CIP/SIP capable (Clean-In-Place / Sterilize-In-Place).
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Validated for particulate and endotoxin reduction (typically <0.1 EU/container after washing + depyrogenation).
Salient Features of Aseptic Washing Machine
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Geneva mechanism.
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Four inner, one outer and one air wash.
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Sequence of washes of washes to customer’s choice
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Stationary nozzles eliminate contamination of water cycles.
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Easy loading and unloading with two rows.
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Individual solenoid valve for each washing sequence.
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Pumps and tanks are mounted on parable stand for easy maintenance.
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Easy operation.
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Higher capacity centrifugal pumps to wash bigger bottles.
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The stationary nozzles avoid chipping of bottle necks.
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Bottle guide system especially for lightweight bottle.
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Pumps and Tanks are mounted on portable stand for easy maintenance.
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Separate panel control to avoid any short circuit due to spraying of water.
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S.S. glycerin fill pressure meter.
Process Operation of Aseptic Bottle Washer
The bottles are loaded on the subsequent indexing part of rotating platform and are cleared in series of operations. Specially designed bottle holders are provided to hold bottles with neck diameter. The bottles are placed in an inverted position in these cup shaped holders. Spraying showers does the external cleaning of the bottles. Solenoid valves are provided to enable the regulation of wash timings, it also spraying water when bottle are stopped means ensure saving of water and sequence of various washing media to suit specific requirement.
Technical Specification of Aseptic Washer Machine
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Model No |
ARBW – 64 | ARBW – 100 |
| Production Output | Up to 60 Bottles / Minute (Depending on Bottle Size) |
Up to 100 Bottles / Minute (Depending on Bottle Size) |
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Input Specification |
Diameter of the container: 25 mm to 100mm Outside Diameter of Neck: 20 mm to 38 mm (with the help of change parts) Height of the container: Up to 280 mm (with the help of change parts) |
Diameter of the container: 25 mm to 100mm Outside Diameter of Neck: 20 mm to 38 mm (with the help of change parts) Height of the container: Up to 280 mm (with the help of change parts) |
| Power Supply | Main Unit: 0.75 H.P., 380 Volt, 3 Phase, 4 Wire System, 50 Hz
Optional Accessories (2 Pumps – Pumping Station) 0.75 H.P., 380 Volt, 3 Phase, 4 Wires System, 50 Hz Electric Heater Tank: 2 K.W. |
Main Unit: 0.75 H.P., 380 Volt, 3 Phase, 4 Wire System, 50 Hz Optional Accessories (2 Pumps – Pumping Station) 0.75 H.P., 380 Volt, 3 Phase, 4 Wires System, 50 Hz Electric Heater Tank: 2 K.W. |
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Overall Dimension |
1550 mm (L) x 1700 mm (W) x 1300 mm (H) approx. | 1800 mm (L) x 1700 mm (W) x 1300 mm (H) approx. |
| Air Consumption | 30 CFM @ 5 bar |
30 CFM @ 5 bar |
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Net Weight |
650 kgs. approx. |
750 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
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