Single Needle Ampoule Filling Machine

A Single Needle Ampoule Filling Machine is a specialized piece of equipment designed for the precise filling and sealing of glass ampoules, primarily used in pharmaceutical, biotech, cosmetic, and chemical industries. It is typically employed for small-scale or laboratory production, offering a compact and efficient solution for filling sterile liquids or powders into ampoules with high accuracy.

Single Needle Ampoule Filling Machine Video

Key Features and Functionality:

1. Purpose and Application:

   • Used for filling and sealing open-mouth glass ampoules with liquid or powder products, such as injectable drugs, veterinary medicines, or cosmetics.

   • Ideal for small-scale injectable companies, research labs, and parenteral production units requiring low to medium output.

2. Construction and Materials:

   • Built with high-grade stainless steel 316L for filling contact parts to meet cGMP (Current Good Manufacturing Practice) standards, ensuring hygiene and durability.

   • Features a compact, monoblock design where the filler and sealer are integrated on a single platform, optimizing space and operation.

3. Design and Construction:

   • Compact cGMP Model: Built to comply with Current Good Manufacturing Practices (cGMP) standards, ensuring hygiene and quality.

   • Material: Contact parts are made of high-quality Stainless Steel 316 (for filling nozzles and syringes), while non-contact parts are made of Stainless Steel 304, ensuring durability and resistance to corrosion.

   • Ergonomic Design: Features a compact footprint with easy-to-clean surfaces and minimal changeover parts for different ampoule sizes, reducing downtime.

4. Filling Mechanism:

   • Operates on a volumetric piston-pump principle or, in some cases, a peristaltic pump for precise dosing.

   • Features in-process control (IPC) to monitor filling weight and ensure accuracy.

   • Non-contact filling reduces the risk of particulate contamination.

5. Additional Features:

   • Neck Centering: Ensures accurate alignment of the ampoule neck during gas flushing, filling, and sealing operations for consistent results.

   • Waste Elimination: Burned-off ampoule tips are clipped and ejected into a separate container to maintain cleanliness.

   • Optional Laminar Air Flow: Can be integrated for Class 100 sterile filling, ensuring a contamination-free environment.

6. Advantages:

   • Precision and Sterility: Provides high accuracy in filling and sealing, critical for pharmaceutical applications.

   • Flexibility: Accommodates various ampoule sizes with minimal changeover time.

   • Ease of Use: Manual settings allow operators to adjust filling volumes, and the machine supports quick integration with existing production lines.

   • Safety and Hygiene: Stainless steel construction and nitrogen flushing ensure compliance with stringent safety standards.

   • Cost-Effective: Suitable for small-scale production, reducing the need for large, expensive machinery.

7. Optional Features:
   • Inbuilt laminar airflow for sterile filling.

• PLC systems for real-time monitoring and parameter adjustments.

Why Choose a Single Needle Ampoule Filling Machine?

This machine is recommended for its simplicity, precision, and suitability for small-scale operations. It ensures sterile, accurate filling and sealing with minimal operator intervention, making it ideal for laboratories, startups, or facilities with lower production demands. Its compact design and compliance with cGMP standards make it a reliable choice for producing high-quality ampoules.

Types of Ampoule Filling Machines

• Small Ampoule Filling Machine
• Ampoule Filling and Sealing Machine
• Onion Skin Ampoule Filling Machine
• Servo Driven Ampoule Filling Machine
• Peristaltic Pump type Ampoule Filling Machine
• Closed Ampoule Filling Machine
• Single Head Ampoule Filling Machine
• Two Head Ampoule Filling Machine
• Four Head Ampoule Filling Machine
• Six Head Ampoule Filling Machine
• Eight Head Ampoule Filling Machine

Salient Features of Single Needle Ampoule Filling Machine

• Compact cGMP model.

• Production output up to 1800 ampoules/hour.

• All contact parts made from high quality Stainless Steel 316 & other Non-contact parts made from Stainless Steel 304.

• Suitable to fill 1ml to 20ml ampoule size and minimum change over parts from one size to another.

• “No Ampoule – No Filling” system.

• Ampoule neck centering during gas flushing and filling operations.

• Possibility of nitrogen gas flushing before, during and after filling.

• Full accessibility allows easy maintenance.

• Equipped with pre-warming station for perfect sealing operations.

• Flow Meters for regulating flames easily.

• Minimum change over time, little maintenance, easy cleaning.

Process Operation of Single Needle Ampoule Filling Machine

Empty washed & sterilized ampoules fed into in-feed hopper from the left hand side of the machine to receiving rack. The moving rack which moves horizontally collect one ampoule from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position through pre-gassing. Pre-gassing, Filling, Post Gassing, Pre-heating & sealing stations completes filling & sealing operations. Filled & sealed ampoules are collected automatically in SS tray in upright position without hand touch.

The machine performs the following operations:

• Ampoule feeding by in-feed hopper, cassettes and ampoule transfer into transport rack.

• One ampoule advanced per machine stroke.

• Centering of ampoules necks during pre-heating, post heating, gas flushing and liquid filling.

• Rotation of ampoules neck in the pre- heating and heating station.

• Elimination of burdened-off ampoule tips by clippers and ejection into a separate container.

Technical Specification of  Ampoule Filling Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.