Single Stroke Ampoule Filling Machine

Q: How does the Single Stroke Ampoule Filling Machine work?

The machine operates on the slant traveling principle for gentle ampoule handling and reduced glass breakage. The automated process includes: Loading of sterilized ampoules into the hopper Nitrogen pre-flushing to remove oxygen Precise single-stroke volumetric filling with neck centering Nitrogen post-flushing Neck pre-warming Accurate flame sealing using LPG + Oxygen burners It features “No Ampoule – No Filling” and “No Ampoule – No Seal” safety systems to prevent wastage and maintain high sterility.

Description

Single Stroke Ampoule Filling Machine is a compact, versatile piece of equipment designed for filling and sealing glass ampoules in pharmaceutical, biotech, cosmetic, and chemical industries. It operates on a single-stroke mechanism, meaning one ampoule is processed per machine cycle, making it ideal for small-scale or lab-scale production with outputs typically up to 1,800 ampoules per hour. It automatically handles the filling of sterile liquids (such as vaccines, antibiotics, or serums) into pre-washed and sterilized glass ampoules, followed by sealing them using a gas flame to ensure product integrity and sterility. Limitations see in below details:

Lower output compared to multi-head machines (e.g., four or six-stroke models), making it less suitable for high-volume production.

Typically designed for open-mouth glass ampoules, though some models support closed ampoules with modifications.

This machine ensures compliance with cGMP standards for sterile injectable filling. If you need details on specific models, pricing, or comparisons with multi-head machines, let me know!

Salient Features of Single Stroke Ampoule Filling Machine

Compact cGMP model.
Production output up to 1800 ampoules/hour.
Full accessibility allows easy maintenance.
Flow Meters for regulating flames easily.
“No Ampoule – No Filling” system.
Equipped with pre-warming station for perfect sealing operations.

Ampoule neck centering during gas flushing and filling operations.
Possibility of nitrogen gas flushing before, during and after filling.
All contact parts made from high quality Stainless Steel 316 & other Non-contact parts made from Stainless Steel 304.
Suitable to fill 1ml to 20ml ampoule size and minimum change over parts from one size to another.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Single Stroke Ampoule Filling Machine

Empty washed & sterilized ampoules fed into in-feed hopper from the left hand side of the machine to receiving rack. The moving rack which moves horizontally collect one ampoule from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position through pre-gassing. Pre-gassing, Filling, Post Gassing, Pre-heating & sealing stations completes filling & sealing operations. Filled & sealed ampoules are collected automatically in SS tray in upright position without hand touch.

The machine performs the following operations:

Ampoule feeding by in-feed hopper, cassettes and ampoule transfer into transport rack.
One ampoule advanced per machine stroke.
Centering of ampoules necks during pre-heating, post heating, gas flushing and liquid filling.
Rotation of ampoules neck in the pre- heating and heating station.
Elimination of burdened-off ampoule tips by clippers and ejection into a separate container.

Technical Specification of Single Stroke Ampoule Filling Machine

Model	AFS-30
Production Output	Up to 25 ampules/minute
Ampoule Size	1ml to 30ml
Filling Accuracy	± 1%
Require Gas for Sealing	LPG & Oxygen (O₂)
Nitrogen Flushing	Pre & Post Nitrogen Flushing Available
Power Specification	0.5 H. P.
Electrical Characteristics	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non Contact Parts	Made from Stainless Steel 304
Overall Dimension	915mm (L) x 610mm (W) x 965mm (H) approx.
Net Weight	150 Kgs. approx.
Gross Weight	225 Kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Single Stroke Ampoule Filling Machine

Compact and cost-effective for small to medium batch production.

Minimal changeover parts for different ampoule sizes (1ml to 20ml), reducing downtime.

Easy maintenance and cleaning due to accessible design.

Ensures sterile, precise filling and sealing, maintaining product integrity.

Key Features of Single Stroke Ampoule Filling Machine

Operation: Empty, sterilized ampoules are loaded into an in-feed hopper and transferred to a transport rack via a star wheel. The machine performs sequential operations: pre-gassing (often with nitrogen), filling, post-gassing, pre-heating, and sealing. Filled and sealed ampoules are collected automatically in an upright position without manual handling.

Capacity: Suitable for filling 1ml to 25ml ampoules with a filling range of 0.5ml to 25ml in a single dose.

Material: Contact parts are typically made of high-quality Stainless Steel 316L, and non-contact parts use Stainless Steel 304, ensuring compliance with cGMP standards.

Design: Built on a stainless steel square pipe frame with a matt finish, featuring a large bottom opening for easy cleaning and maintenance. A pendant-type electrical control panel enhances operational ease and safety.

Nitrogen Flushing: Offers optional nitrogen gas flushing before, during, and after filling to prevent oxidation and ensure product stability.

Sealing: Uses oxygen and LPG (propane) for precise sealing, with rollers rotating ampoules during sealing for uniform closure. Waste glass tips are clipped and ejected into a separate container.

Applications: Widely used for filling injectable liquids, veterinary medicines, agro-insecticides, and cosmetic products.

FAQ for Single Stroke Ampoule Filling Machine

What is a Single Stroke Ampoule Filling Machine?

A Single Stroke Ampoule Filling Machine is a compact, fully automatic monobloc machine designed for precise filling and flame sealing of sterile liquid injectables into glass ampoules. It uses a single filling stroke (single needle/single head) and integrates nitrogen flushing (pre- and post-filling), volumetric piston filling, neck pre-heating, and LPG + Oxygen flame sealing in one unit. This model is ideal for small to medium batch production, R&D laboratories, pilot plants, and low-volume pharmaceutical manufacturing. It fully complies with cGMP, USFDA, and WHO standards.

What is the production capacity of the Single Stroke Ampoule Filling Machine?

The Single Stroke Ampoule Filling Machine (Model AFS-1) has a production capacity of up to 25 ampoules per minute (approximately 1,500 ampoules per hour). It supports ampoule sizes from 1ml to 30ml, with a filling range of 0.5ml to 25ml and excellent filling accuracy of ±1%. This makes it the perfect choice for low to medium output requirements.

How does the Single Stroke Ampoule Filling Machine work?

The machine operates on the slant traveling principle for gentle ampoule handling and reduced glass breakage. The automated process includes:

Loading of sterilized ampoules into the hopper
Nitrogen pre-flushing to remove oxygen
Precise single-stroke volumetric filling with neck centering
Nitrogen post-flushing
Neck pre-warming
Accurate flame sealing using LPG + Oxygen burners

It features “No Ampoule – No Filling” and “No Ampoule – No Seal” safety systems to prevent wastage and maintain high sterility.

What are the key features of the Single Stroke Ampoule Filling Machine?

Key features include:

Single stroke / single head monobloc design
Nitrogen flushing before, during, and after filling
Precision piston pump for accurate dosing
Tool-less quick changeover with minimal parts
All product contact parts made of SS 316L
Slant design for smooth movement and low glass particle generation
Pre-heating station and precise flame control
Compact footprint suitable for cleanrooms and R&D setups
Easy cleaning, low maintenance, and optional PLC/HMI control

What are the main benefits of the Single Stroke Ampoule Filling Machine?

Main benefits include:

Ideal for R&D, pilot scale, and small to medium batch production
Lower initial investment and easy maintenance compared to multi-head machines
High filling accuracy (±1%) with minimal product wastage
Gentle handling that reduces glass breakage and contamination risk
Compact design that saves valuable cleanroom space
Fast format changeover and easy validation
Full cGMP compliance with reliable and consistent performance

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