Automatic Vial Filling Machine

Description

Automatic Vial Filling Machine is a high-precision, automated pharmaceutical packaging equipment designed to fill liquid or semi-liquid medications into glass or plastic vials with extreme accuracy, sterility, and speed. Automatic Vial Filling Machine are essential in pharmaceutical, biotech, and cosmetic industries for aseptic filling of injectables, vaccines, eye drops, and other sensitive products.

This cGMP-compliant machine ensures high filling accuracy, minimal contamination risk, and seamless integration with upstream (vial washing & sterilizing) and downstream (rubber stoppering, capping & labeling) equipment to form a complete sterile production line.

The Automatic Vial Filling Machine delivers consistent quality, high throughput, reduced labor, and full regulatory compliance (USFDA, WHO, cGMP). It is ideal for manufacturers looking for reliable, efficient, and sterile liquid vial filling solutions.

Working Principle of Automatic Vial Filling Machine

The incoming dry vials (sterilized and siliconized) are fed through the unscrambler and suitably guided on the moving Delrin slat conveyor belt at the required speed of the correct placement below filling unit.

 

The filling unit consists of Filling Head, Syringes & Nozzles; Syringes & Nozzles are made of AISI SS 316L materials. A Star Wheel is provided which holds the vial during filling operation. A sensor is provided for ”No Vial-No Filling” operation. Syringes are mounted on eccentric block and driving through bottom main gear box. Volume can be increase & decrease by increasing or decreasing stroke length of piston as per filling size. Syringes is having non return valve for sucking and delivering situation to avoid volume variation. Liquid reaches to filling nozzles through silicon transparent pipe. Nozzles having up & down movement with help of cam mechanism, and it come down when vial hold by starwheel for filling operation and starts filling when it starts to move up and after completion of filling operation, starwheel delivers two vials together on conveyor for rubber stoppering operation.

 

Stoppering unit consist of Star wheel, Vibrator unit and Bowl. The sterilized and siliconized rubber stoppers stored in the vibrator bowl moves vertically to the rubber stopper chute. The vial is hold firmly by starwheel, which will be in continuous rotary motion and vial which is coming from filling unit get in to starwheel and move in rotary direction along with starwheel, during movement it picks up the rubber stopper from the exit end of the chute and rubber stopper pressed by fix single pressing roller, which is spring loaded. Then vial further move on conveyor and collected on out feed starwheel for next sealing operation.

Technical Specification of Automatic Vial Filling Machine

Model

ALVF-40

ALVF-80

ALVF-120

ALVF – 250

Filling Heads

Two

Four

Eight

Twelve

Production Rate

Up to 40 Vials/Minute

Up to 80 Vials/Minute

Up to 150 Vials/Minute

Up to 250 Vials/Minute

Input Specification

    

Vial Diameter

15mm to 70mm

15mm to 70mm

15mm to 70mm

15mm to 70mm

Vial Height

25mm to 140mm

25mm to 140mm

25mm to 140mm

25mm to 140mm

Filling Precision

±1%

±1%

±1%

±1%

Power Required

1 H.P.

1.5 H.P.

2 H.P.

2 H.P.

Electrical Characteristics

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

440 Volts, 3 Phase, 50 Hertz

Overall Dimension

2050mm (L) x 850mm (W) x 1700mm (H)

2200mm (L) x 850mm (W) x 1700mm (H)

3000mm (L) x 945mm (W) x 1700mm (H)

3500mm (L) x 945mm (W) x 1700mm (H)

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Vial Filling Machine

Applications of Vial Filling Machine

Benefits of Automatic Vial Filling Machine

Excellent Filling Accuracy

High Production Output and Efficiency

Superior Sterility and Product Safety

Versatility and Easy Changeover

Low Operating Cost and Easy Maintenance

Seamless Line Integration and Compliance

Key Components of Automatic Vial Filling Machine

  • Vial Feeding System: Automatic unscrambler or conveyor feeds vials in upright position

 

  • Washing Station (Optional): Cleans vials with WFI (Water for Injection) and sterile air

 

  • Sterilization Tunnel (Optional): De-pyrogenates vials using hot air (up to 300°C)

 

  • Filling Station: Peristaltic pumps, piston pumps, or time-pressure systems for precise dosing

 

  • Stoppering/Capping Unit: Places rubber stoppers and aluminum caps (flip-off or tear-off)

 

  • Nitrogen Purging (Optional): Displaces oxygen to extend shelf life

 

  • Checkweigher/Reject System: Detects under/over-filled or defective vials

 

  • Laminar Air Flow (LAF)/Isolator: Ensures Class 100/ISO 5 cleanroom conditions

FAQ for Automatic Vial Filling Machine

Our Automatic Vial Filling Machine is available in four models with the following outputs:

  • ALVF-40 (2 filling heads): Up to 40 vials per minute
  • ALVF-80 (4 filling heads): Up to 80 vials per minute
  • ALVF-120 (8 filling heads): Up to 150 vials per minute
  • ALVF-250 (12 filling heads): Up to 250 vials per minute

The actual speed depends on vial size, fill volume (2ml to 250ml), and liquid viscosity. All models provide consistent filling accuracy of ±1%.

The machine handles a wide range of vial sizes:

  • Vial Diameter: 15mm to 70mm
  • Vial Height: 25mm to 140mm

It supports fill volumes from 2ml to 250ml. Changeover between different vial sizes is quick and requires minimum change parts. The versatile design makes it suitable for both small-batch and large-scale sterile liquid filling in pharmaceutical production.

Sterility and accuracy are maintained through:

  • Operation under Laminar Air Flow (Class 100) environment.
  • No Vial – No Filling” sensor to prevent wastage and contamination.
  • All product contact parts made of AISI SS 316L.
  • Optional nitrogen flushing before and after filling to minimize oxidation.
  • High-precision volumetric piston pumps with non-return valves.

The compact monoblock design and advanced safety features ensure compliance with USFDA, WHO, and cGMP guidelines for sterile injectable production.

Power requirements are model-specific:

  • ALVF-40: 1 HP
  • ALVF-80: 1.5 HP
  • ALVF-120 & ALVF-250: 2 HP

(All models operate on 440 Volts, 3 Phase, 50 Hz – customizable as per your country’s voltage.)

Key features include:

  • Variable AC frequency drive for speed control
  • Digital vial counter
  • Safety clutch to avoid vial breakage
  • Easy integration with vial washing, sterilizing, rubber stoppering, and capping machines
  • Optional PLC with HMI touchscreen and PRIME feature for quick line cleaning

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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