Dry Powder Injection Filling Machine

Description

Dry Powder Injection Filling Machine are specialized pharmaceutical equipment designed to precisely fill sterile dry powders into glass or plastic vials for reconstitution into injectable solutions. These machines ensure high accuracy, sterility, and compliance with cGMP and FDA standards, often integrating filling, stoppering, and sealing in a single monoblock system. They are critical for handling sensitive formulations, offering advantages like extended shelf life and reduced energy costs compared to lyophilization.

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Working Principle of Dry Powder Injection Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

 

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

 

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Dry Powder Injection Filling Machine

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machines

Applications of Powder Filling Machines

Advantages of Dry Powder Injection Filling Machine

Superior Sterility and Product Safety

High Filling Accuracy and Minimal Wastage

Hygienic Design and Easy Maintenance

Regulatory Compliance and Line Integration

Versatility and Cost Efficiency

Key Features of Dry Powder Injection Filling Machine

  • Dosing System: Vacuum-pressure or auger-based dosing with servo-driven powder wheels.

 

  • Sterility: Operates under laminar airflow (LAF) in Class 100/ISO 5 cleanrooms.

 

  • Stoppering & Sealing: Integrated rubber bung insertion and aluminum cap sealing.

 

  • Control Systems: PLC/HMI with sensors for vial jams and in-process checkweighing (IPC).

 

  • Construction: SS 316L contact parts; explosion-proof options for volatile powders.

FAQ for Dry Powder Injection Filling Machine

The machine offers a filling accuracy of ±2–3% (depending on powder characteristics, bulk density uniformity, and environmental conditions).

  • APF 12S (Single Head): Up to 100 vials/minute
  • APF 12D (Double Head): Up to 200 vials/minute Fill range: 50mg to 10 grams (up to 1500mg in single dosing with change parts).

It is ideal for sterile dry powder injectables such as antibiotics and other sensitive pharmaceutical formulations in the Pharmaceutical and Biotech industries. The machine handles vial sizes from 5ml to 250ml and supports high-sterility requirements in controlled cleanroom environments.

  • Compact cGMP model with all contact parts in SS316L (easily removable for autoclaving/sterilization).
  • Servo-driven powder wheel and vial transport, vacuum-driven dosing, and tool-less doctor/wiper blade adjustment.
  • Built-in turn tables, integrated rubber stoppering system, and safety features like clutch for vial breakage protection.
  • Options include PLC with HMI, inbuilt Laminar Air Flow (Class 100), “No Vial – No Fill”, IQ/OQ documentation, and sampling/rejection systems.

  • Superior sterility assurance and product safety for injectable powders.
  • High precision dosing with minimal wastage and consistent results.
  • Hygienic design with easy cleaning, fast changeover, and low maintenance.
  • High-speed automated operation suitable for large-scale production.
  • Full regulatory compliance (cGMP/FDA) and seamless integration into complete sterile vial filling lines.

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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