

Dry Powder Injection Filling Machine are specialized pharmaceutical equipment designed to precisely fill sterile dry powders into glass or plastic vials for reconstitution into injectable solutions. These machines ensure high accuracy, sterility, and compliance with cGMP and FDA standards, often integrating filling, stoppering, and sealing in a single monoblock system. They are critical for handling sensitive formulations, offering advantages like extended shelf life and reduced energy costs compared to lyophilization.
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The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.
The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.
The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
A Dry Powder Injection Filling Machine is specialized aseptic equipment designed to fill sterile dry powders into glass or plastic vials for reconstitution into injectable solutions. It uses a vacuum-driven powder wheel with pistons: sterilized powder is agitated in the hopper for uniform bulk density, sucked into the wheel ports via vacuum, excess powder is doctored off, and then flushed into vials using compressed or nitrogen gas. Vials are immediately stoppered to maintain sterility throughout the process.
The machine offers a filling accuracy of ±2–3% (depending on powder characteristics, bulk density uniformity, and environmental conditions).
It is ideal for sterile dry powder injectables such as antibiotics and other sensitive pharmaceutical formulations in the Pharmaceutical and Biotech industries. The machine handles vial sizes from 5ml to 250ml and supports high-sterility requirements in controlled cleanroom environments.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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