Dry Powder Injection Filling Machine

Dry Powder Injection Filling Machine are specialized pharmaceutical equipment designed to precisely fill sterile dry powders into glass or plastic vials for reconstitution into injectable solutions. These machines ensure high accuracy, sterility, and compliance with cGMP and FDA standards, often integrating filling, stoppering, and sealing in a single monoblock system. They are critical for handling sensitive formulations, offering advantages like extended shelf life and reduced energy costs compared to lyophilization.

Dry Powder Injection Filling Machine Video

Key Features

• Dosing System: Vacuum-pressure or auger-based dosing with servo-driven powder wheels.

• Sterility: Operates under laminar airflow (LAF) in Class 100/ISO 5 cleanrooms.

• Stoppering & Sealing: Integrated rubber bung insertion and aluminum cap sealing.

• Control Systems: PLC/HMI with sensors for vial jams and in-process checkweighing (IPC).

• Construction: SS 316L contact parts; explosion-proof options for volatile powders.

Applications

• Primary Use: Filling sterile powders like antibiotics, acyclovir, or biologics into vials for reconstitution.

• Industries: Pharmaceuticals (sterile injectables), biotech (vaccines, peptides).

• Vial Compatibility: 2ml to 100ml glass/plastic vials; adaptable for tube vials.

• Special Features: Some models support spray-freeze-dried pellets or moisture-sensitive powders.

Salient Features of Dry Powder Injection Filler Machine

• Compact GMP Model.

• Suitable to fill 50mg to 1500mg in single dosing.

• Powder wheel rotation and vial transportation through servo motors.

• Vacuum driven specially designed Powder Wheels.

• All contact parts made of SS316L materials with easy removal system for Autoclaving / Sterilization.

• Filling Accuracy of ± 2% depending upon powder characteristics and environmental conditions.

• Built in Rubber Stoppering System.

• Multiple dosing system with the help of change parts.

• Built in Turn Tables with Separate Drive for speed control of infeed and outfeed of vials.

• Various safety features including Clutch system for Vial Breakage.

• Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.

• IQ/OQ Validation documentation can be provided.

• PLC system with Graphical User Interface can be offered.

• Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.

• Sampling and Rejection system can be provided on demand.

Process Operation of Injectable Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Dry Powder Injection Filling Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.