Sterile Powder Filling Machine

Description

Sterile Powder Filling Machine is specialized equipment designed for the precise, contamination-free filling of powdered substances—typically pharmaceuticals like antibiotics, vaccines, or high-potency APIs—into sterile containers such as glass vials, syringes, or cartridges. Sterile Powder Filling Machine are essential in aseptic processing environments to ensure product sterility, accuracy, and compliance with cGMP (current Good Manufacturing Practices) standards. They are widely used in the pharmaceutical, biotechnology, and sometimes food industries for injectable or inhalation products where stability in liquid form is not feasible.

  • Sterile powder handling: Powder is stored in a hopper, agitated for uniform density, and dosed using vacuum-assisted wheels or gravimetric systems.

 

  • Filling: Precise volumes (e.g., 50mg to 1500mg) are transferred into containers under laminar airflow or isolator conditions to prevent microbial contamination.

 

  • Stoppering/Capping: Often integrated, with automatic insertion of rubber stoppers and sealing.

 

  • Sterilization: Contact parts are autoclavable, and systems support VHP (Vaporized Hydrogen Peroxide) or dry heat depyrogenation.

 

Sterile Powder Filling Machine minimize waste, ensure fill accuracy (±1%), and support high speeds while maintaining a Class 100 sterile environment.

If you need details on specific models and pricing, let me know!

Working Principle of Sterile Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Sterile Powder Filling Machine

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machines

Applications of Powder Filling Machines

Advantages of Sterile Powder Filling Machine

High-Speed Automated Production

High Filling Accuracy and Minimal Wastage

Regulatory Compliance and Line Integration

Versatility and Operational Efficiency

Key Features of Sterile Powder Filling Machine

When selecting a machine, focus on:

 

  • Powder Properties: Handles fine, hygroscopic, or high-potency powders with varying flowability.

 

  • Output and Accuracy: From lab-scale (20 vials/min) to high-speed (300+ vials/min), with ±0.5-1% fill precision.

 

  • Sterility Assurance: Enclosed pathways, easy-to-sterilize SS316L parts, and compatibility with RABS or isolators.

 

  • Flexibility: Adjustable for vial sizes (2-50ml) and multi-dose capabilities.

FAQ for Sterile Powder Filling Machine

The machine provides a filling accuracy of ±2–3% (depending on powder characteristics, bulk density uniformity, and environmental conditions).

  • APF 12S (Single Head): Up to 100 vials/minute
  • APF 12D (Double Head): Up to 200 vials/minute Fill range: 50mg to 10 grams (with multiple dosing options).

It is ideal for sterile dry powders such as antibiotics, vaccines, and high-potency APIs in the Pharmaceutical and Biotech industries. The machine handles vial sizes from 5ml to 250ml and operates effectively in controlled cleanroom environments with Class 100 laminar airflow.

  • Compact cGMP model with SS316L contact parts (easily removable for autoclaving/sterilization).
  • Vacuum-driven dosing with mechanical agitators, tool-less doctor/wiper blade adjustment, and built-in rubber stoppering unit.
  • “No Vial – No Fill” system, safety clutch for vial breakage protection, and individual drives for filling & stoppering.
  • Variable AC frequency drive, digital production counter, and options for PLC/HMI and inbuilt Laminar Air Flow.

  • Ensures superior sterility and product safety in aseptic processing.
  • High precision with minimal wastage and consistent dosing.
  • Hygienic design with easy cleaning, fast changeover, and low maintenance.
  • High-speed automated operation suitable for large-scale production.
  • Regulatory compliance (cGMP) and seamless integration into complete sterile vial filling lines.

Countries We Export to

United States | Canada | Mexico | Brazil | Argentina | Chile | Colombia | Peru | Germany | United Kingdom | France | Italy | Spain | Netherlands | Belgium | Switzerland | Sweden | Austria | Denmark | Norway | Poland | Finland | Czech Republic | Hungary | Portugal | Ireland | Greece | Slovakia | Romania | Bulgaria | China | Japan | India | South Korea | Indonesia | Vietnam | Thailand | Malaysia | Philippines | Singapore | Bangladesh | Pakistan | Saudi Arabia | United Arab Emirates | Israel | Turkey | Iran | Qatar | Kuwait | South Africa | Nigeria | Egypt | Algeria | Morocco | Kenya | Ghana | Tunisia | Australia | New Zealand | Russia | Ukraine | Belarus | Kazakhstan | Taiwan | Hong Kong | South Sudan | Uzbekistan | Oman | Jordan | Bahrain | Sri Lanka | Myanmar | Lebanon | Mongolia | Ethiopia | Libya | Angola | Zambia | Zimbabwe | Mozambique | Ivory Coast | Senegal | Uganda | Tanzania | Botswana | Ecuador | Venezuela | Bolivia | Paraguay | Uruguay | Trinidad and Tobago | Panama | Guatemala | Costa Rica | Honduras | El Salvador | Nicaragua | Dominican Republic | Haiti | Cuba

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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