Injectable Powder Filling and Rubber Bunging Machine

Description

Injectable Powder Filling and Bunging Machine also known as a vial dry powder filling machine or sterile powder filler is a specialized piece of pharmaceutical equipment designed for the precise filling of sterile powders into glass vials, followed by immediate bunging (insertion of rubber stoppers) to maintain sterility and integrity. These machines are essential in the production of injectable medications, such as antibiotics, vaccines, or lyophilized drugs, ensuring compliance with cGMP (current Good Manufacturing Practice) standards. They minimize contamination risks by integrating filling and stoppering on a single monobloc platform, often under laminar airflow for Class 100 sterile environments. Injectable Powder Filling and Bunging Machine are widely used in pharmaceutical manufacturing lines, where they can handle vial sizes from 2ml to 100ml, filling doses ranging from 50mg to 1500mg with high accuracy (±1% for uniform density powders).

  • Vial Feeding: Sterilized vials enter via a turntable or slat conveyor belt, then move to a star wheel for indexing.

 

  • Powder Preparation: Sterile powder is stored in a hopper with mechanical agitators to ensure uniform density. It’s pre-loaded into a secondary hopper.

 

  • Filling: Vials reach the powder wheel station. Vacuum suction draws precise powder volumes into wheel ports. The powder is then dispensed into vials. Servo-driven wheels ensure consistent dosing.

 

  • Bunging/Stoppering: Immediately after filling, rubber stoppers are fed from a vibrating bowl and pressed into vials using pneumatic or mechanical presses.

 

  • Exit and Integration: Filled and bunged vials exit via conveyor for downstream processes like capping, labeling, or inspection. The entire process is enclosed to avoid exposure.

 

This vacuum-air pressure system ensures no powder spillage and high volumetric accuracy, making it ideal for sensitive injectables.

If you need details on specific models and pricing, let me know!

Working Principle of Injectable Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Injectable Powder Filling Machine

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machines

Applications of Powder Filling Machines

Advantages of Injectable Powder Filling and Rubber Bunging Machine

Superior Sterility & Contamination Control

Excellent Filling Accuracy & Consistency

Easy Operation & Maintenance

Enhanced Product Stability & Safety

Key Features of Injectable Powder Filling and Rubber Bunging Machine

  • Compact Design: Built on a sturdy frame with access doors for easy maintenance.

 

  • Sterility Controls: Inbuilt HEPA filters, laminar airflow, and optional isolators for aseptic processing.

 

  • Safety Mechanisms: “No Vial, No Fill” and “No Stopper, No Bung” systems to prevent product loss; rejection/sampling stations for quality checks.

 

  • Versatility: Supports half/full bunging for lyophilized products; compatible with dry/wet rubber stoppers.

 

  • Advanced Controls: PLC with HMI touchscreens, servo motors for precise indexing, and vacuum-based filling for accuracy.

FAQ for Injectable Powder Filling and Rubber Bunging Machine

The machine is available in two models:

  • APF 12S (Single Head): Up to 100 vials per minute
  • APF 12D (Double Head): Up to 200 vials per minute

Fill volume ranges from 50 mg to 10 grams (with multiple dosing options). Filling accuracy is ±2% to ±3%, depending on powder bulk density uniformity and environmental control.

It is designed for sterile dry powder injectables in the pharmaceutical and biotech industries. Compatible vial sizes range from 5ml to 250ml. The vacuum powder wheel system handles powders with varying flow properties effectively. All product contact parts are SS316L for easy sterilization and full cGMP compliance.

  • Compact cGMP model with built-in rubber bunging/stoppering unit
  • No Vial – No Fill” system to eliminate wastage
  • Vacuum powder wheel with adjustable piston depth and multiple dosing
  • Safety clutch system to prevent vial breakage
  • Individual drives with variable AC frequency drive for filling and bunging
  • Easy-to-remove SS316L contact parts for autoclaving and tool-less adjustments
  • Digital production counter, optional PLC/HMI, and Laminar Air Flow (Class 100) support

These features ensure high sterility, efficiency, and minimal downtime.

Immediate rubber bunging after filling protects moisture-sensitive powders, maintains sterility, and enhances product stability until reconstitution. The machine is fully cGMP-compliant. Maintenance is straightforward: all contact parts are easily removable for autoclaving/sterilization. Regular cleaning of the powder wheel, hopper, agitators, doctor blade, and bunging components is recommended, along with controlled cleanroom conditions (temperature & humidity).

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Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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