Automatic Injectable Powder Filling Machine

An Automatic Injectable Powder Filling Machine is a specialized piece of pharmaceutical equipment designed for the aseptic filling of sterile dry powders into glass vials, followed by rubber stoppering (bunging). These machines are critical in the production of injectable drugs, ensuring high precision, sterility, and compliance with standards like GMP, 21 CFR, and ISO 9001:2015. They are typically used in cleanroom environments with laminar airflow, HEPA filters, and isolator technology to prevent contamination.

Injectable Powder Filling Machine Video

Process Involves:

1. Vial Feeding: Vials are fed via turntables or conveyor belts.

2. Powder Filling: Using a vacuum-air pressure system or servo-driven auger/piston mechanism to dispense micro-doses with accuracy of ±1-2%.

3. Stoppering: Automatic insertion of rubber stoppers using vibratory bowls.

4. Output: Machines handle vial sizes from 2-100 ml, with speeds ranging from 60-400 vials per minute (VPM), depending on configuration.

Automatic Injectable Powder Filling Machine reduce manual intervention, minimize powder waste, and include safety features like “no vial, no fill” and rejection systems for defective units.

Applications and Benefits

• Applications: Primarily for sterile injectables like cephalosporins, penicillin powders, or lyophilized drugs. Also adaptable for dry syrups or talcum powders.

• Benefits:

  • Efficiency: High throughput reduces labor costs and downtime.

  • Precision: Servo/auger systems ensure uniform dosing, critical for regulatory compliance.

  • Hygiene: All wetted parts are autoclavable; minimal powder exposure.

  • Scalability: Modular designs allow integration into full vial filling lines.

Salient Features of Automatic Injectable Powder Filler

• Compact GMP Model.

• Suitable to fill 50mg to 1500mg in single dosing.

• Powder wheel rotation and vial transportation through servo motors.

• Vacuum driven specially designed Powder Wheels.

• All contact parts made of SS316L materials with easy removal system for Autoclaving / Sterilization.

• Filling Accuracy of ± 2% depending upon powder characteristics and environmental conditions.

• Built in Rubber Stoppering System.

• Multiple dosing system with the help of change parts.

• Built in Turn Tables with Separate Drive for speed control of infeed and outfeed of vials.

• Various safety features including Clutch system for Vial Breakage.

• Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.

• IQ/OQ Validation documentation can be provided.

• PLC system with Graphical User Interface can be offered.

• Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.

• Sampling and Rejection system can be provided on demand.

Process Operation of Injectable Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Injectable Powder Filling Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.