Automatic Injectable Powder Filling Machine

Q: What is the filling accuracy and production speed of the Automatic Injectable Powder Filling Machine?

The machine provides a filling accuracy of ±2–3% (depending on powder characteristics, bulk density uniformity, and environmental conditions). APF 12S (Single Head) : Up to 100 vials/minute APF 12D (Double Head) : Up to 200 vials/minute Fill range: 50mg to 10 grams (up to 1500mg in single dosing).

Q: What are the key features of the Automatic Injectable Powder Filling Machine?

Compact cGMP model with SS316L contact parts (easily removable for autoclaving). Servo-driven powder wheel and vial transport, vacuum-driven dosing, and tool-less doctor/wiper blade adjustment. Built-in turn tables, rubber stoppering system, and safety features like clutch for vial breakage protection. Options include PLC with HMI, inbuilt Laminar Air Flow (Class 100), “No Vial – No Fill”, IQ/OQ documentation, and sampling/rejection systems.

Description

Automatic Injectable Powder Filling Machine is a specialized piece of pharmaceutical equipment designed for the aseptic filling of sterile dry powders into glass vials, followed by rubber stoppering (bunging). These machines are critical in the production of injectable drugs, ensuring high precision, sterility, and compliance with standards like GMP, 21 CFR, and ISO 9001:2015. They are typically used in cleanroom environments with laminar airflow, HEPA filters, and isolator technology to prevent contamination.

Vial Feeding: Vials are fed via turntables or conveyor belts.

Powder Filling: Using a vacuum-air pressure system or servo-driven auger/piston mechanism to dispense micro-doses with accuracy of ±1-2%.

Stoppering: Automatic insertion of rubber stoppers using vibratory bowls.

Output: Machines handle vial sizes from 2-100 ml, with speeds ranging from 60-400 vials per minute (VPM), depending on configuration.

Automatic Injectable Powder Filling Machine reduce manual intervention, minimize powder waste, and include safety features like “no vial, no fill” and rejection systems for defective units.

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Salient Features of Automatic Injectable Powder Filling Machine

Compact GMP Model.
Filling Accuracy of ± 2% depending upon powder characteristics and environmental conditions.
Powder wheel rotation and vial transportation through servo motors.
Vacuum driven specially designed Powder Wheels.
All contact parts made of SS316L materials with easy removal system for Autoclaving / Sterilization.
Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.
Built in Turn Tables with Separate Drive for speed control of infeed and outfeed of vials, Built in Rubber Stoppering System.

Suitable to fill 50mg to 1500mg in single dosing.
Multiple dosing system with the help of change parts.
Various safety features including Clutch system for Vial Breakage.
IQ/OQ Validation documentation can be provided.
PLC system with Graphical User Interface can be offered.
Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.
Sampling and Rejection system can be provided on demand.

Working Principle of Automatic Injectable Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Automatic Injectable Powder Filling Machine

Models	APF 12S	APF 12D
Production Output	Up to 100 vials/minute	Up to 200 vials/minute
Fill Volume	50 mg. to 10grams	50 mg. to 10 grams
Vial Size	5ml to 250ml	5ml to 250ml
Filling Accuracy	± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder	± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder
Power Load	3.5 H. P.	4.5 H. P.
Overall Dimension	2600mm (L) X 1100mm (W) X 1800mm (H) approx.	3000mm (L) X 1100mm (W) X 1800mm (H) approx.
Net Weight	500 kgs. approx.	700 kgs. approx.
Gross Weight	750 kgs. approx.	950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machines

Antibiotic Powder Filling Machine

Injectable Powder Filling Machine

Auger Powder Filling Machine

Bottle Dry Injectable Filling Machine

Automatic Dry Syrup Powder Filling Machine

Dry Syrup Powder Filler Capper

Dry Syrup Powder Filling Machine

Double Head Auger Powder Filling Machine

Applications of Powder Filling Machines

Benefits of Automatic Injectable Powder Filling Machine

Efficiency: High throughput reduces labor costs and downtime.

Precision: Servo/auger systems ensure uniform dosing, critical for regulatory compliance.

Hygiene: All wetted parts are autoclavable; minimal powder exposure.

Scalability: Modular designs allow integration into full vial filling lines.

Key Features of Automatic Injectable Powder Filling Machine

Compact cGMP Model — Designed for sterile pharmaceutical production with full compliance to regulatory standards.

High Filling Accuracy — Achieves ±2–3% accuracy (depending on powder characteristics, bulk density uniformity, and environmental conditions).

Servo-Driven Operation — Powder wheel rotation and vial transportation controlled by servo motors for precise and smooth performance.

Vacuum-Driven Powder Wheel — Specially designed powder wheel with pistons and ports for accurate volumetric dosing via vacuum suction.

Material Construction — All product contact parts made of SS316L with easy removal system for autoclaving/sterilization.

Tool-Less Adjustments — Easy external adjustment of Doctor Blade and Wiper Blade for quick setup and minimal downtime.

Built-in Turn Tables & Stoppering — Separate drives for infeed/outfeed vial control and integrated rubber stoppering system.

Dosing Flexibility — Suitable for 50mg to 10 grams (or up to 1500mg) in single dosing; multiple dosing possible with change parts.

Safety Features — Includes clutch system for vial breakage protection, “No Vial – No Fill” system, and other interlocks.

Advanced Options — PLC with HMI, Inbuilt Laminar Air Flow for Class 100 sterile filling, IQ/OQ documentation, and sampling/rejection systems.

FAQ for Automatic Injectable Powder Filling Machine

What is an Automatic Injectable Powder Filling Machine and how does it work?

An Automatic Injectable Powder Filling Machine is a specialized aseptic filling system designed for filling sterile dry powders into glass vials, followed by automatic rubber stoppering. It uses a vacuum-driven powder wheel with pistons: sterilized powder is agitated in the hopper for uniform density, precisely sucked into wheel ports via vacuum, excess is doctored off, and then flushed into vials using compressed or nitrogen air. Filled vials are immediately stoppered to maintain sterility.

What is the filling accuracy and production speed of the Automatic Injectable Powder Filling Machine?

The machine provides a filling accuracy of ±2–3% (depending on powder characteristics, bulk density uniformity, and environmental conditions).

APF 12S (Single Head): Up to 100 vials/minute
APF 12D (Double Head): Up to 200 vials/minute Fill range: 50mg to 10 grams (up to 1500mg in single dosing).

What types of products and containers can the Automatic Injectable Powder Filling Machine handle?

It is ideal for sterile injectable powders (e.g., antibiotics and other dry powder injectables) in the Pharmaceutical and Biotech industries. The machine handles vial sizes from 5ml to 250ml. It is designed for high-sterility applications in controlled cleanroom environments.

What are the key features of the Automatic Injectable Powder Filling Machine?

Compact cGMP model with SS316L contact parts (easily removable for autoclaving).
Servo-driven powder wheel and vial transport, vacuum-driven dosing, and tool-less doctor/wiper blade adjustment.
Built-in turn tables, rubber stoppering system, and safety features like clutch for vial breakage protection.
Options include PLC with HMI, inbuilt Laminar Air Flow (Class 100), “No Vial – No Fill”, IQ/OQ documentation, and sampling/rejection systems.

What are the main advantages of using an Automatic Injectable Powder Filling Machine?

Ensures superior sterility and product safety for injectable powders.
High precision with minimal wastage and consistent dosing.
Hygienic, easy-to-clean design with fast changeover and low maintenance.
High-speed automated operation suitable for large-scale production.
Full regulatory compliance support and seamless integration into complete sterile vial filling lines.

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