

Injectable Powder Filling and Bunging Machine also known as a vial dry powder filling machine or sterile powder filler is a specialized piece of pharmaceutical equipment designed for the precise filling of sterile powders into glass vials, followed by immediate bunging (insertion of rubber stoppers) to maintain sterility and integrity. These machines are essential in the production of injectable medications, such as antibiotics, vaccines, or lyophilized drugs, ensuring compliance with cGMP (current Good Manufacturing Practice) standards. They minimize contamination risks by integrating filling and stoppering on a single monobloc platform, often under laminar airflow for Class 100 sterile environments. Injectable Powder Filling and Bunging Machine are widely used in pharmaceutical manufacturing lines, where they can handle vial sizes from 2ml to 100ml, filling doses ranging from 50mg to 1500mg with high accuracy (±1% for uniform density powders).
This vacuum-air pressure system ensures no powder spillage and high volumetric accuracy, making it ideal for sensitive injectables.
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The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
Vial Size | 5ml to 250ml | 5ml to 250ml |
Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
Power Load | 3.5 H. P. | 4.5 H. P. |
Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
Net Weight | 500 kgs. approx. | 700 kgs. approx. |
Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
An Injectable Powder Filling and Rubber Bunging Machine (also known as Vial Dry Powder Filling and Stoppering Machine) is a monobloc aseptic system designed for filling sterile dry powders into glass vials followed by immediate insertion of rubber stoppers (bungs). It integrates filling and bunging in one compact unit to maintain sterility, making it ideal for producing injectable antibiotics, vaccines, and lyophilized drugs under cGMP standards.
The machine is available in two models:
Fill volume ranges from 50 mg to 10 grams (with multiple dosing options). Filling accuracy is ±2% to ±3%, depending on powder bulk density uniformity and environmental control.
It is designed for sterile dry powder injectables in the pharmaceutical and biotech industries. Compatible vial sizes range from 5ml to 250ml. The vacuum powder wheel system handles powders with varying flow properties effectively. All product contact parts are SS316L for easy sterilization and full cGMP compliance.
These features ensure high sterility, efficiency, and minimal downtime.
Immediate rubber bunging after filling protects moisture-sensitive powders, maintains sterility, and enhances product stability until reconstitution. The machine is fully cGMP-compliant. Maintenance is straightforward: all contact parts are easily removable for autoclaving/sterilization. Regular cleaning of the powder wheel, hopper, agitators, doctor blade, and bunging components is recommended, along with controlled cleanroom conditions (temperature & humidity).
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
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