Parenterals Bottle Powder Filling Machine

Q: What is the production capacity and filling accuracy of the machine?

The machine is available in two models: AI-DPM 12 : Up to 80 bottles per minute AI-DPM 16 : Up to 120 bottles per minute It handles fill volumes from 5g to 70g per dose (with change parts). Filling accuracy is ±2% , depending on the powder characteristics, when operated at controlled humidity below 28% RH.

Q: Why is humidity control important and what are the key maintenance features?

Humidity must be maintained below 28% RH to ensure filling accuracy and prevent powder clumping or bridging, especially with moisture-sensitive injectables. Key maintenance-friendly features include: Tool-less adjustment of doctor blade and wiper blade Easily removable contact parts for cleaning/autoclaving “No Bottle – No Fill” and low air/vacuum stop systems Toughened glass safety cabinet and cGMP-compliant design for minimal downtime.

Description

Parenterals Bottle Powder Filling Machine is specialized equipment used in pharmaceutical manufacturing to accurately and sterilely fill dry powders into glass or plastic bottles or vials under aseptic conditions. These machines are critical for parenteral (injectable) drug production, ensuring compliance with GMP (Good Manufacturing Practices), FDA regulations, and ISO standards to prevent contamination. They typically integrate filling, stoppering, and sometimes capping in a monoblock or rotary design.

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Salient Features of Parenterals Bottle Powder Filling Machine

Filling Accuracy of ±2% depending on powder at controlled humidity below 28% Rh.
Automatic Infeed and Exit of Bottles through Star Wheel System.
Rotary Bottle Movement System with Rotary Funnel System
Funnel with Unique Vibratory system for filling semi free flow powder at higher speed.
All contact parts with easy removal system for Cleaning / Autoclaving / Sterilization.
Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.

Compact cGMP Model.
“No Bottle – No Fill” System
No Bottle at infeed conveyor – Automatic Machine on/off system.
Machine construction in SS304 material.
Low Air – Machine Stop System, Low Vacuum – Machine Stop System.
Toughened Glass Safety Cabinet.

Working Principle of Parenterals Bottle Powder Filling Machine

The incoming sterilized dry bottle is fed through the in-feed turn table. Suitable guide supply bottles on to flat conveyor belt at the required speed for feeding. There is filling head mounted on machine top plate in the same line.

When bottle reaches to the mechanical holder detained filling station, Bottle sensor sense the bottles and Magnetic clutch starts to rotate which is mounted on auger shaft. It fills the desired amount of powder into the bottle through auger, where rotation time is previously determined.

Duly filled bottles go upward on to the sealing station with the help of SS conveyor belt.

Technical Specification of Parenterals Bottle Powder Filling Machine

Models	AI-DPM 12	AI-DPM 16
Production Output	Up to 80 bottles/minute	Up to 120 bottles/minute
Bottle Diameter	Up to 85mm	Up to 85mm
Bottle Height	Up to 200mm	Up to 200mm
Fill Volume	5gms. To 70gms. in Single Dose with the help of change parts for different fill volume	5gms. To 70gms. in Single Dose with the help of change parts for different fill volume
Fill Accuracy	± 2% Depending upon the Powder, under the controlled level of Humidity	± 2% Depending upon the Powder, under the controlled level of Humidity
Humidity	Below 28% Rh required on machine to be arrange by customer	Below 28% Rh required on machine to be arrange by customer
Power	2.0 H.P. For Machine and 3.0 H.P. For Vacuum Pump	2.5 H.P. For Machine and 3.0 H.P. For Vacuum Pump
Overall Dimension	1700 mm (L) x 1000 mm (W) x 1800 mm approx.	2000 mm (L) x 1200 mm (W) x 1800 mm approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machine

Antibiotic Powder Filling Machine

Injectable Powder Filling Machine

Auger Powder Filling Machine

Bottle Dry Injectable Filling Machine

Automatic Dry Syrup Powder Filling Machine

Dry Syrup Powder Filler Capper

Dry Syrup Powder Filling Machine

Double Head Auger Powder Filling Machine

Applications of Powder Filling Machine

Advantages of Parenterals Bottle Powder Filling Machine

Superior Sterility and Product Safety

High Filling Accuracy and Minimal Waste

Compact GMP-Compliant Design and Easy Operation/Maintenance

Regulatory Compliance and Cost Efficiency

Key Features of Parenterals Bottle Powder Filling Machine

Filling Mechanism: Often uses volumetric methods like vacuum/pressure systems, auger dosing, or servo-driven pistons for precise dosing with accuracy up to ±1-2%.

Aseptic Design: Includes laminar airflow, isolators, hydrogen peroxide sanitization, and 100% in-process control (IPC) to maintain Class 100 cleanroom standards and minimize dust exposure.

Containment: Protects operators from potent or toxic powders via enclosed systems and filtration.

Automation: Servo motors for speed adjustment during filling/weighing/stoppering; options for rejection systems and integration with washers, sealers, and labelers.

FAQ for Parenterals Bottle Powder Filling Machine

What is a Parenterals Bottle Powder Filling Machine?

A Parenterals Bottle Powder Filling Machine is specialized pharmaceutical equipment designed to accurately and aseptically fill sterile dry powders into glass or plastic bottles/vials. It is primarily used for injectable (parenteral) drugs, dry syrups, and antibiotics. The machine maintains sterility under controlled conditions (e.g., low humidity) and complies with GMP, FDA, and ISO standards to prevent contamination.

What is the production capacity and filling accuracy of the machine?

The machine is available in two models:

AI-DPM 12: Up to 80 bottles per minute
AI-DPM 16: Up to 120 bottles per minute

It handles fill volumes from 5g to 70g per dose (with change parts). Filling accuracy is ±2%, depending on the powder characteristics, when operated at controlled humidity below 28% RH.

How does the Parenterals Bottle Powder Filling Machine work?

Sterilized bottles are fed via an infeed turntable and star wheel onto a conveyor. A bottle sensor detects the container and activates a magnetic clutch-driven auger. Powder is dispensed through a vibratory funnel system into the bottle. Filled bottles then move to the sealing station. The rotary system with “No Bottle – No Fill” logic ensures precision and minimal waste.

What types of powders and containers can the machine handle?

It is ideal for sterile dry injectable powders, antibiotics, dry syrups, and other semi-free-flowing or non-free-flowing pharmaceutical powders. The machine handles bottles with diameters up to 85mm and heights up to 200mm. All product contact parts are made of SS316 (or Nylon/HDPE options) for easy cleaning and sterilization.

Why is humidity control important and what are the key maintenance features?

Humidity must be maintained below 28% RH to ensure filling accuracy and prevent powder clumping or bridging, especially with moisture-sensitive injectables. Key maintenance-friendly features include:

Tool-less adjustment of doctor blade and wiper blade
Easily removable contact parts for cleaning/autoclaving
“No Bottle – No Fill” and low air/vacuum stop systems
Toughened glass safety cabinet and cGMP-compliant design for minimal downtime.

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