A Parenterals Bottle Powder Filling Machine is specialized equipment used in pharmaceutical manufacturing to accurately and sterilely fill dry powders into glass or plastic bottles or vials under aseptic conditions. These machines are critical for parenteral (injectable) drug production, ensuring compliance with GMP (Good Manufacturing Practices), FDA regulations, and ISO standards to prevent contamination. They typically integrate filling, stoppering, and sometimes capping in a monoblock or rotary design.
Parenterals Bottle Powder Filling Machine Video
Key Features and Technologies
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Filling Mechanism: Often uses volumetric methods like vacuum/pressure systems, auger dosing, or servo-driven pistons for precise dosing with accuracy up to ±1-2%.
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Aseptic Design: Includes laminar airflow, isolators, hydrogen peroxide sanitization, and 100% in-process control (IPC) to maintain Class 100 cleanroom standards and minimize dust exposure.
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Containment: Protects operators from potent or toxic powders via enclosed systems and filtration.
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Automation: Servo motors for speed adjustment during filling/weighing/stoppering; options for rejection systems and integration with washers, sealers, and labelers.
Common Applications
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Filling sterile powders into vials or bottles for injectables.
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Used in pharma, biotech, and nutraceutical industries for both sterile and non-sterile products.
Salient Features of Powder Filling Machine
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Compact GMP Model.
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No Bottle – No Fill System
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Rotary Bottle Movement System with Rotary Funnel System
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Funnel with Unique Vibratory system for filling semi free flow powder at higher speed.
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All contact parts with easy removal system for Cleaning / Autoclaving / Sterilization.
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Machine construction in SS304 material.
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Filling Accuracy of ±2% depending on powder at controlled humidity below 28% Rh.
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Automatic Infeed and Exit of Bottles through Star Wheel System.
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No Bottle at infeed conveyor – Automatic Machine on/off system.
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Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.
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Low Air – Machine Stop System.
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Low Vacuum – Machine Stop System.
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Toughened Glass Safety Cabinet.
Working Principle of Bottle Powder Filling Machine
The incoming sterilized dry bottle is fed through the in-feed turn table. Suitable guide supply bottles on to flat conveyor belt at the required speed for feeding. There is filling head mounted on machine top plate in the same line.
When bottle reaches to the mechanical holder detained filling station, Bottle sensor sense the bottles and Magnetic clutch starts to rotate which is mounted on auger shaft. It fills the desired amount of powder into the bottle through auger, where rotation time is previously determined.
Duly filled bottles go upward on to the sealing station with the help of SS conveyor belt.
Technical Specification of Parenterals Powder Filler Machine
| Models | AI-DPM 12 | AI-DPM 16 |
| Production Output | Up to 80 bottles/minute | Up to 120 bottles/minute |
| Bottle Diameter | Up to 85mm | Up to 85mm |
| Bottle Height | Up to 200mm | Up to 200mm |
| Fill Volume | 5gms. To 70gms. in Single Dose with the help of change parts for different fill volume | 5gms. To 70gms. in Single Dose with the help of change parts for different fill volume |
| Fill Accuracy | ± 2% Depending upon the Powder, under the controlled level of Humidity | ± 2% Depending upon the Powder, under the controlled level of Humidity |
| Humidity | Below 28% Rh required on machine to be arrange by customer | Below 28% Rh required on machine to be arrange by customer |
| Power | 2.0 H.P. For Machine and 3.0 H.P. For Vacuum Pump | 2.5 H.P. For Machine and 3.0 H.P. For Vacuum Pump |
| Overall Dimension | 1700 mm (L) x 1000 mm (W) x 1800 mm approx. | 2000 mm (L) x 1200 mm (W) x 1800 mm approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
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