Six Head Ampoule Filling Machine

Q: Which ampoule sizes can the Six Head Ampoule Filling Machine handle?

This machine is suitable for ampoule sizes from 1 ml to 10 ml (extendable up to 20 ml with change parts). It features quick format changeover with minimum change parts. The slant travel mechanism ensures smooth and gentle handling of ampoules with varying neck dimensions and glass thickness.

Q: What materials are used in the construction of the Six Head Ampoule Filling Machine?

All product contact parts are manufactured from high-quality Stainless Steel 316L , while non-contact parts and the sturdy frame use Stainless Steel 304 with a matte finish. This material selection ensures corrosion resistance, easy cleaning, long operational life, and full compliance with pharmaceutical industry standards.

Description

Six Head Ampoule Filling Machine (Model AFS-6) is a high-speed, fully automatic pharmaceutical equipment designed for precise filling and sealing of glass ampoules. It is ideal for medium to large-scale production of sterile liquid injectables, offering significantly higher output compared to four-head models. This advanced machine works on the slant travel principle, where ampoules move at an angle through various stations. This design accommodates variations in ampoule neck dimensions and thicknesses, ensuring gentle handling, accurate filling, and uniform sealing while maintaining strict sterility and cGMP compliance. Six Head Ampoule Filling and Sealing Machine is a high-precision, automated piece of equipment designed for filling and sealing glass ampoules in pharmaceutical, biotech, cosmetic, and chemical industries.

Control System: Equipped with a pendant-type electrical control panel for safe and easy operation. Some models include PLC and HMI for automatic fill volume adjustments and real-time monitoring.

Safety and Compliance: CE-certified and 21 CFR Part 11-compliant models are available. Features like safety valves, pressure reducers, and stainless steel hoods for fume extraction ensure operator safety and environmental protection.

Cooling System: Efficient cooling prevents overheating, extending machine lifespan.

Versatility: Some models support both open and closed-mouth ampoules, with options for integration with washing, sterilization, and labeling systems for a complete production line.

Salient Features of Six Head Ampoule Filling Machine

Compact cGMP model.
Higher output up to 9000 Ampoules per hour.
Full accessibility allows easy maintenance.
Flow Meters for regulating flames easily.
“No Ampoule – No Filling” system.
Machine equipped with pre-warming station.

Ampoule neck centering during gas flushing and filling operations.
Possibility of nitrogen gas flushing before, during and after filling.
All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Minimum change over parts from 1ml to 10ml ampoule size.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Six Head Ampoule Filling Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect six ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Technical Specification of Six Head Ampoule Filling Machine

Model Name	AFS-6
Production Speed	Up to 150 ampules/minute
Ampoule Sizes	1 ml to 20 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	2 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	2000mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Benefits of Six Head Ampoule Filling Machine

High Precision: Ensures accurate dosing and reliable sealing, critical for pharmaceutical safety.

Efficiency: High output and fast changeover times boost productivity.

Flexibility: Handles a wide range of ampoule sizes and liquid types with minimal adjustments.

Aseptic Processing: Nitrogen flushing and sterile design minimize contamination risks.

Durability: Stainless steel construction ensures long-term reliability and compliance with GMP standards.

Key Features of Six Head Ampoule Filling Machine

Design and Construction:
- Principle of Operation: Built on the principle of slant travel of ampoules during filling and sealing to accommodate variations in ampoule neck dimensions, thickness, and ovality. This ensures compatibility with a wide range of standard glass ampoules.
- Material: Contact parts are made of high-quality Stainless Steel 316L, compliant with cGMP standards, while non-contact parts are typically Stainless Steel 304. This ensures durability, corrosion resistance, and hygiene.
- Frame: Constructed with a sturdy stainless steel square pipe frame, fully encompassed with stainless steel coverings in a matte finish for aesthetic appeal and ease of cleaning. A large bottom opening facilitates thorough cleaning and maintenance.

Filling and Sealing Process:
- Ampoule Handling: Sterilized ampoules are loaded into a slant hopper, and a synchronized star wheel delivers them one by one (or in groups of six) to an eccentric transport rack. The rack pauses sequentially for pre-gassing, filling, post-gassing, pre-heating, and sealing operations.
- Filling Capacity: Suitable for filling 0.5ml to 10ml or 1ml to 20ml ampoules, depending on the model. Some machines support up to 30ml with minimal changeover parts.
- Filling Mechanism: Utilizes volumetric piston pumps, peristaltic pumps, or servo-driven systems for precise liquid filling. Nitrogen flushing (pre- and post-filling) is available to prevent contamination and oxidation.
- Sealing: Features pre-warming and sealing stations using combustible gases (oxygen and LPG/propane). Specially designed rollers rotate ampoules during sealing to ensure uniform, high-quality seals with a sealing efficiency of up to 99.8%. Waste tips are clipped and collected separately.

Output and Efficiency:
- Production Capacity: Typically ranges from 80 to 150 ampoules per minute, with some models achieving up to 9000 ampoules per hour for large-scale production. Output varies based on ampoule size (e.g., 120 ampoules/min for 1ml ampoules).
- Changeover Time: Minimal changeover time for different ampoule sizes (1ml to 10ml or 20ml) due to fewer changeover parts, enhancing operational efficiency.
- No Ampoule, No Fill System: Prevents wastage of costly liquids by ensuring filling only occurs when an ampoule is present.

Applications:
- Widely used for filling sterile injectables (e.g., vaccines, drugs), agro-insecticides, veterinary medicines, and cosmetic products. Suitable for liquids, powders, or viscous substances like oils.

Maintenance and Cleaning:
- Designed for easy maintenance with full accessibility and minimal downtime. The large bottom opening and removable parts simplify cleaning, meeting stringent aseptic requirements.

Optional Features:
- Pre-warming station for perfect sealing.
- Laminar Air Flow (LAF), isolators, or RABS (Restricted Access Barrier Systems) for enhanced sterility.
- Servo-based or peristaltic pump filling for high-precision needs.
- Combination machines for processing both ampoules and vials.

FAQ for Six Head Ampoule Filling Machine

What is the production capacity of the Six Head Ampoule Filling Machine?

The Six Head Ampoule Filling Machine (Model AFS-6) can fill and seal up to 150 ampoules per minute, which translates to approximately 9,000 ampoules per hour. With six filling heads working simultaneously, it is designed for higher-volume sterile liquid production while maintaining excellent filling accuracy and cGMP compliance.

Which ampoule sizes can the Six Head Ampoule Filling Machine handle?

This machine is suitable for ampoule sizes from 1 ml to 10 ml (extendable up to 20 ml with change parts). It features quick format changeover with minimum change parts. The slant travel mechanism ensures smooth and gentle handling of ampoules with varying neck dimensions and glass thickness.

What is the filling accuracy and how does the machine maintain sterility?

The Six Head Ampoule Filling Machine offers a filling accuracy of ±1%. Sterility is ensured through pre- and post-nitrogen gas flushing with neck centering, a “No Ampoule – No Filling” system, pre-warming station before sealing, and full cGMP-compliant design. All product contact parts are made of Stainless Steel 316L, and the machine supports operation under laminar airflow (Class 100 environment).

What materials are used in the construction of the Six Head Ampoule Filling Machine?

All product contact parts are manufactured from high-quality Stainless Steel 316L, while non-contact parts and the sturdy frame use Stainless Steel 304 with a matte finish. This material selection ensures corrosion resistance, easy cleaning, long operational life, and full compliance with pharmaceutical industry standards.

What industries is the Six Head Ampoule Filling Machine suitable for?

The Six Head Ampoule Filling Machine is primarily used in the pharmaceutical industry for sterile injectables, vaccines, antibiotics, and other liquid formulations. It is also ideal for biotech, veterinary, cosmetics (serums and high-value liquids), and certain chemical applications that require precise, contamination-free filling and sealing of glass ampoules.

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Six Head Ampoule Filling Machine

Description

Salient Features of Six Head Ampoule Filling Machine

Working Principle of Six Head Ampoule Filling Machine

Technical Specification of Six Head Ampoule Filling Machine

Types of Ampoule Filling Machine

Applications of Ampoule Filling Machine

Benefits of Six Head Ampoule Filling Machine

High Precision: Ensures accurate dosing and reliable sealing, critical for pharmaceutical safety.

Efficiency: High output and fast changeover times boost productivity.

Flexibility: Handles a wide range of ampoule sizes and liquid types with minimal adjustments.

Aseptic Processing: Nitrogen flushing and sterile design minimize contamination risks.

Durability: Stainless steel construction ensures long-term reliability and compliance with GMP standards.

Key Features of Six Head Ampoule Filling Machine

FAQ for Six Head Ampoule Filling Machine

Countries We Export to

Partner with Industry Experts

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