Two Head Ampoule Filling Machine

Q: How does the Two Head Ampoule Filling Machine work?

The machine works on the slant travel (walking beam) principle: Pre-sterilized ampoules are loaded into the hopper and transferred via star wheel. Nitrogen pre-gassing removes oxygen from the ampoules. Two filling heads accurately dose the liquid using volumetric syringes. Optional post-gassing with nitrogen is performed. Pre-heating and gas flame sealing (LPG + Oxygen) creates a hermetic seal. Filled and sealed ampoules are automatically discharged on the outfeed tray. It includes a “No Ampoule – No Fill” system and neck centering for zero wastage and perfect sealing every time.

Q: Which industries and products is the Two Head Ampoule Filling Machine suitable for?

The Two Head Ampoule Filling Machine is widely used in: Pharmaceuticals — Sterile injectables, vaccines, antibiotics, analgesics, and insulin Biotechnology — Biological products and R&D batches Veterinary — Animal health injectables Cosmetics — High-value sterile serums and liquids It is especially suitable for small to medium production runs where flexibility, accuracy, and sterility are essential.

Description

Two Head Ampoule Filling Machine (Model: AFS-2) is a compact, high-precision automatic ampoule filling and sealing machine designed for small to medium batch production of sterile injectable liquids. Manufactured by Adinath International, this cGMP-compliant machine simultaneously fills and hermetically seals two glass ampoules in each cycle using volumetric piston pumps (syringes). It is widely preferred by pharmaceutical companies, biotech firms, and contract manufacturers for producing high-quality injectable products such as vaccines, antibiotics, analgesics, insulin, and veterinary formulations with excellent filling accuracy and minimal product wastage.

Pre-sterilized empty ampoules are loaded into the hopper and transferred to the moving rack.

Pre-gassing — Nitrogen flushing removes oxygen from the ampoule.

Filling — Two filling heads accurately dose the liquid using volumetric syringes.

Post-gassing — Optional nitrogen flushing after filling to protect oxygen-sensitive products.

Sealing — Pre-heating followed by precise flame sealing creates a hermetic pull-seal or tip-seal.

Filled and sealed ampoules are automatically collected on the outfeed tray in upright position.

Salient Features of Two Head Ampoule Filling Machine

Compact cGMP model.
Higher output up to 3000 Ampoules per hour.
Full accessibility allows easy maintenance.
Flow Meters for regulating flames easily.
“No Ampoule – No Filling” system.
Machine equipped with pre-warming station.

Ampoule neck centering during gas flushing and filling operations.
Possibility of nitrogen gas flushing before, during and after filling.
All contact parts made from high quality Stainless Steel 316 & other Non-contact parts made from Stainless Steel 304.
Minimum change over parts from 1ml to 10ml ampoule size.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Two Head Ampoule Filling Machine

Empty washed & sterilized ampoules receive automatically on wire mesh conveyor belt from outfeed of sterilizing tunnel. Ampoule fed automatically into in-feed hopper from the left hand side of the machine and feed to receiving rack through cassette. The moving rack which moves horizontally collect two ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position through pre-gassing. Pre-gassing, Filling, Post Gassing, Pre-heating & sealing station.

Technical Specification of Two Head Ampoule Filling Machine

Model Name	AFS-2
Production Speed	Up to 50 ampules/minute
Ampoule Sizes	1 ml to 30 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	0.5 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	915mm (L) x 760mm (W) x 965mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Benefits of Two Head Ampoule Filling Machine

High precision and efficiency with minimal product loss.

Compact design requiring less floor space, ideal for small to medium-scale facilities.

Customizable filling mechanisms (piston, servo, or peristaltic) to meet specific needs.

Robust, durable construction for long-term use with minimal upkeep.

Energy-efficient with automated features to streamline production.

Key Features and Description of Two Head Ampoule Filling Machine

Construction: Made with a stainless steel (SS) square pipe frame and SS 316L contact parts for durability and compliance with cGMP standards. Non-contact parts are typically SS 304, with a matte finish for aesthetic appeal and ease of cleaning.

Filling Capacity: Suitable for filling 1ml to 25ml ampoules, with a dosing range of 0.5ml to 25ml per cycle. It operates using volumetric piston pumps, servo-driven pumps, or peristaltic pumps, depending on customization.

Output: Capable of filling 30 to 90 ampoules per minute (approximately 1,800 to 5,400 ampoules per hour), ideal for small to medium-scale production.

Operation: Fully automatic with minimal human intervention. Ampoules are loaded into an in-feed hopper, transferred via a synchronized star wheel to a transport rack, and moved through sequential stations:
- Pre-Nitrogen Flushing: Inert gas (nitrogen) is flushed to reduce oxygen exposure.
- Filling: Two filling heads discharge precise liquid volumes, with neck centering for accuracy.
- Post-Nitrogen Flushing: Additional nitrogen flush to maintain sterility.
- Pre-Heating: A low-pressure flame warms ampoules for sealing.
- Sealing: Uses oxygen and LPG (propane) with specially designed rollers for uniform sealing of open or closed-type ampoules (Type B and C).

Sealing Process: Features a two-stage sealing system (pre-heating and final sealing) to ensure clean, precise seals. Waste tips are collected in a high-quality SS container.

Flexibility: Minimal changeover parts required for different ampoule sizes (1ml to 20ml or 30ml, depending on the model). Format parts can be changed by hand without tools.

Control System: Equipped with a user-friendly touchscreen interface for adjusting fill volume, speed, and sealing temperature. Some models include PLC-based controls for automated fill volume adjustments and an automatic stop function to prevent accidents and reduce wastage.

Maintenance: Designed for low maintenance with easy-clean features, including a large bottom opening for access. Stainless steel construction ensures corrosion resistance and sterility.

Safety and Compliance: Complies with GMP and CE standards. Optional safety cabinets, laminar airflow, or isolators can be integrated for sterile Class 100 filling. Energy-saving features, such as automatic shut-off when idle, reduce operational costs.

Additional Features:
- Dead tray for upright ampoule collection.
- Pre-warming station for thick glass ampoules to ensure perfect sealing.
- Adjustable ampoule loading tray for handling various sizes.
- Optional servo-driven or peristaltic pump for enhanced precision and sterility.

FAQ for Two Head Ampoule Filling Machine

What is a Two Head Ampoule Filling Machine?

The Two Head Ampoule Filling Machine (Model AFS-2) is a compact automatic ampoule filling and sealing machine designed for small to medium batch production. It simultaneously fills and hermetically seals two glass ampoules per cycle using volumetric piston pumps. Manufactured by Adinath International, this cGMP-compliant machine is ideal for pharmaceutical companies requiring precise, sterile filling of injectables, vaccines, antibiotics, and other liquid formulations with high accuracy and minimal wastage.

What is the production capacity of the Two Head Ampoule Filling Machine?

The Two Head Ampoule Filling Machine delivers an output of up to 50 ampoules per minute (approximately 3,000 ampoules per hour). It can efficiently handle ampoule sizes ranging from 1 ml to 30 ml. This makes it the perfect choice for small to medium-scale production, pilot batches, and scaling up from single-head machines.

How does the Two Head Ampoule Filling Machine work?

The machine works on the slant travel (walking beam) principle:

Pre-sterilized ampoules are loaded into the hopper and transferred via star wheel.
Nitrogen pre-gassing removes oxygen from the ampoules.
Two filling heads accurately dose the liquid using volumetric syringes.
Optional post-gassing with nitrogen is performed.
Pre-heating and gas flame sealing (LPG + Oxygen) creates a hermetic seal.
Filled and sealed ampoules are automatically discharged on the outfeed tray.

It includes a “No Ampoule – No Fill” system and neck centering for zero wastage and perfect sealing every time.

What are the key features of the Two Head Ampoule Filling Machine?

Compact cGMP model with easy maintenance
All contact parts made of SS 316L stainless steel
Pre & post nitrogen gas flushing facility
Pre-warming station for strong and uniform sealing
“No Ampoule – No Fill” safety system
Flow meters for precise flame regulation
Quick change-over and minimum change parts
Low power consumption (1 H.P.) and compact footprint
Suitable for open-mouth ampoules with ±1% filling accuracy

These features ensure high reliability and compliance with international regulatory standards.

Which industries and products is the Two Head Ampoule Filling Machine suitable for?

The Two Head Ampoule Filling Machine is widely used in:

Pharmaceuticals — Sterile injectables, vaccines, antibiotics, analgesics, and insulin
Biotechnology — Biological products and R&D batches
Veterinary — Animal health injectables
Cosmetics — High-value sterile serums and liquids

It is especially suitable for small to medium production runs where flexibility, accuracy, and sterility are essential.

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