Eight Head Ampoule Filling Machine

Description

Eight Head Ampoule Filling Machine (Model AFS-8) is a high-speed, fully automatic pharmaceutical equipment designed for precise filling and sealing of glass ampoules at large-scale production levels. It is ideal for high-volume manufacturing of sterile liquid injectables, offering significantly higher output compared to four-head and six-head models. This advanced machine operates on the slant travel principle, where ampoules move at an angle through various stations. This design effectively handles variations in ampoule neck dimensions and glass thicknesses, ensuring gentle handling, accurate filling, and uniform sealing while maintaining strict sterility and full cGMP compliance.

PLC-Based Control: Some models include a PLC with an HMI touch screen for automatic fill volume adjustments, reducing manual intervention.

Servo-Based Vertical Models: High-speed vertical fillers with 8, 12, or 16 nozzles for enhanced precision.

Pre-Warming Unit: Ensures proper heating of ampoule necks for flawless sealing, especially for thicker glass.

Gas Flow Meters: Acrylic body meters for easy flame setting (oxygen and LPG).

Optional Features:
1. Safety cabinet with doors and Class 100 laminar airflowfor sterile filling.
2. Compatibility with both open-mouthand closed-mouth (Type B and C)
3. Dead tray for upright collection of filled ampoules and waste tip collector for easy disposal.
4. CE and ISO 9001:2000 certifications for quality assurance.

Salient Features of Eight Head Ampoule Filling Machine

Compact cGMP model.
Higher output up to 12000 Ampoules per hour.
Full accessibility allows easy maintenance.
Flow Meters for regulating flames easily.
“No Ampoule – No Filling” system.
Machine equipped with pre-warming station.

Ampoule neck centering during gas flushing and filling operations.
Possibility of nitrogen gas flushing before, during and after filling.
All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Minimum change over parts from 1ml to 10ml ampoule size.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Eight Head Ampoule Filling Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform Filling and Sealing Operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Sterilized ampoules are loaded into the slant hopper.

A synchronized star wheel delivers ampoules (in groups of eight) to a moving eccentric rack.

Ampoules move through stations for:
- Pre-Nitrogen Flushing: Inert gas to maintain sterility.
- Filling: Precise liquid dosing via chosen pump mechanism.
- Post-Nitrogen Flushing: Additional gas flush to prevent contamination.
- Preheating: Warms ampoule necks for sealing.
- Sealing: Uses LPG/oxygen for a clean, secure seal.

Filled and sealed ampoules are automatically collected in an upright position on a tray, with waste tips ejected into a separate container.

Technical Specification of Eight Head Ampoule Filling Machine

Model Name	AFS-8
Production Speed	Up to 200 ampules/minute
Ampoule Sizes	1 ml to 20 ml
Filling Error	± 1%
Sealing Gas	LPG and Oxygen (O₂)
Nitrogen Gas	Pre & Post Nitrogen
Power Load	2 H. P.
Power Voltage	230 Volts, Single Phase, 50 Hertz
Contact Parts	Made from Stainless Steel 316L
Non-Contact Parts	Made from Stainless Steel 304
Machine Size	2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Eight Head Ampoule Filling Machine

High Precision: Minimal breakage and accurate dosing for high reliability.

Low Maintenance: Quick-change parts and easy cleaning reduce operational costs.

Versatility: Handles a wide range of ampoule sizes and liquid types with customizable filling options.

Sterility: Nitrogen flushing and GMP-compliant materials ensure product safety.

Global Reach: Machines are exported to over 48 countries, with manufacturers like Adinath International offering tailored solutions.

Key Features of Eight Head Ampoule Filling Machine

High-Speed Production:
- Capable of filling and sealing up to 12,000 ampoules per hour (approximately 80–280 ampoules per minute, depending on ampoule size and liquid viscosity). For example, it can process up to 290 ampoules/min for 1ml ampoules, 270 for 2ml, 260 for 3ml, 240 for 5ml, and 150 for 10ml.
- Ideal for medium to large-scale production lines requiring high output with minimal errors.

Filling and Sealing Mechanism:
- Filling Capacity: Handles ampoule sizes from 0.5ml to 25ml in a single dose, with precise volume control. Common models support 1ml to 10ml ampoules, with some offering flexibility up to 20ml.
- Filling Options: Equipped with multiple filling mechanisms, including:
  1. Piston Pump Filling: Ensures consistent dosing for various liquids.
  2. Servo-Driven Filling: Enhances accuracy with programmable control.
  3. Peristaltic Pump Filling: Ideal for sterile operations, minimizing contamination.
- Two-Stage Sealing Process:
  1. Preheating: Removes residual droplets to ensure clean sealing.
  2. Sealing: Uses LPG and oxygen with clippers for precise, defect-free seals.
- Nitrogen Flushing: Pre- and post-filling nitrogen purging to maintain sterility and prevent contamination.

Construction and Compliance:
- Built on a stainless steel square pipe frame with SS 316L contact parts for injectable liquids, ensuring compliance with cGMP standards. Non-contact parts are typically made of SS 304.
- GMP Compliance: Designed for sterility, with contact surfaces ensuring hygiene for injectable liquids.
- Robust Design: Heavy-duty stainless steel piping and anti-rust treatment for durability and jerk-free operation.
- Easy Maintenance: Features a large bottom opening for cleaning and quick-changeover parts to minimize downtime when switching ampoule sizes (1ml to 10ml).

Operational Efficiency:
- Slant Travel Mechanism: Ampoules move in an inclined position through filling and sealing stations, accommodating variations in neck dimensions and thicknesses.
- No Ampoule, No Fill System: Prevents liquid wastage by halting filling when no ampoule is detected.
- Neck Centering: Ensures precise alignment during filling, gas flushing, and sealing for improved accuracy.
- Automated Process: Sterilized ampoules are loaded into a slant hopper, delivered via a synchronized star wheel to an eccentric rack, and processed through pre-gassing, filling, post-gassing, preheating, and sealing stations. Filled ampoules are collected automatically without manual handling.

FAQ for Eight Head Ampoule Filling Machine

What is the production capacity of the Eight Head Ampoule Filling Machine?

The Eight Head Ampoule Filling Machine (Model AFS-8) can fill and seal up to 200 ampoules per minute, which translates to approximately 12,000 ampoules per hour. With eight filling heads operating simultaneously, it is designed for high-volume sterile liquid production. Actual output may vary

Which ampoule sizes can the Eight Head Ampoule Filling Machine handle?

This machine supports ampoule sizes from 1 ml to 20 ml (with some configurations handling 0.5 ml to 25 ml). It features minimum change-over parts and quick format change, allowing easy switching between sizes with very little downtime. The slant travel mechanism ensures gentle and precise handling across different neck dimensions and glass thicknesses.

What is the filling accuracy and how is sterility maintained?

The Eight Head Ampoule Filling Machine offers a filling accuracy of ±1%. Sterility is maintained through pre- and post-nitrogen gas flushing (with neck centering), a “No Ampoule – No Filling” system, a pre-warming station before sealing, and full cGMP-compliant design. All product contact parts are made of Stainless Steel 316L, and the machine can be equipped with optional Class 100 laminar airflow for enhanced sterile operation.

What materials are used in the construction of the Eight Head Ampoule Filling Machine?

All product contact parts are manufactured from high-quality Stainless Steel 316L, while non-contact parts and the sturdy frame use Stainless Steel 304 with a matte finish and anti-rust treatment. This material selection ensures excellent corrosion resistance, easy cleaning, long-term durability, and complete compliance with pharmaceutical standards.

What industries is the Eight Head Ampoule Filling Machine suitable for?

The Eight Head Ampoule Filling Machine is primarily designed for the pharmaceutical industry for high-volume production of sterile injectables, vaccines, antibiotics, and other liquid formulations. It is also widely used in biotech, veterinary, cosmetics (serums and high-value liquids), chemical, and agrochemical industries where precise, contamination-free filling and sealing of glass ampoules is required.

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Eight Head Ampoule Filling Machine

Description

Salient Features of Eight Head Ampoule Filling Machine

Working Principle of Eight Head Ampoule Filling Machine

Technical Specification of Eight Head Ampoule Filling Machine

Types of Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Eight Head Ampoule Filling Machine

High Precision: Minimal breakage and accurate dosing for high reliability.

Low Maintenance: Quick-change parts and easy cleaning reduce operational costs.

Versatility: Handles a wide range of ampoule sizes and liquid types with customizable filling options.

Sterility: Nitrogen flushing and GMP-compliant materials ensure product safety.

Global Reach: Machines are exported to over 48 countries, with manufacturers like Adinath International offering tailored solutions.

Key Features of Eight Head Ampoule Filling Machine

FAQ for Eight Head Ampoule Filling Machine

Countries We Export to

Partner with Industry Experts

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