Glass Ampoule Filling Machine

Q: What is the filling accuracy of the machine?

Our Glass Ampoule Filling Machines utilize high-precision piston pumps (or optional peristaltic/servo systems) to achieve a filling precision of ± 1% . Additionally, the 'No Ampoule – No Filling' system ensures that no liquid is wasted if an ampoule is missing from the station.

Q: Is the machine compliant with international manufacturing standards?

Yes. The machine is a compact model built as per cGMP (Current Good Manufacturing Practice) standards. All contact parts are made from high-quality Stainless Steel 316L , while non-contact parts are made from Stainless Steel 304 , ensuring durability and easy sterilization.

Description

Glass Ampoule Filling Machine are specialized equipment used primarily in pharmaceutical, biotech, cosmetic, and chemical industries to fill and seal glass ampoules with liquids, powders, or other substances. These machines ensure precise dosing, hygienic processing, and airtight sealing to maintain product sterility and integrity. Below is a concise overview based on current information:

Production Needs: Choose based on output requirements (lab-scale vs. industrial-scale).

Ampoule Size: Ensure compatibility with desired sizes (e.g., 1 ml to 30 ml).

Regulatory Compliance: Look for cGMP, FDA, CE, or ISO certification.

Customization: Some manufacturers offer tailored solutions for specific liquids or ampoule types.

Glass Breakage Risk: Improper handling or sealing can lead to contamination or injury from glass fragments.

Maintenance: Requires regular cleaning and calibration to maintain sterile conditions.

Cost: High-speed or custom models can be expensive (e.g., ₹1.4 lakh to ₹8.2 lakh for some models in India).

If you need specific recommendations, pricing details, or a comparison of models for a particular application (e.g., pharmaceutical vs. cosmetic), please provide more details about your requirements.

Salient Features of Glass Ampoule Filling Machine

Compact model as per cGMP standard.
Higher production output up to 12000 Ampoules per hour.
“No Ampoule – No Filling” system.
Machine equipped with pre-warming station.
Full accessibility allows easy maintenance.
Flow Meters for regulating flames easily.

All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
Minimum change over parts from 1ml to 10ml ampoule size.
Ampoule neck centering during gas flushing and filling operations.
Possibility of nitrogen gas flushing before, during and after filling.
Minimum change over time, little maintenance, easy cleaning.

Working Principle of Glass Ampoule Filling Machine

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect one/two/four/eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. For detailed working process please explore Automatic Ampoule Filler Video in top right section of this page.

Technical Specification of Glass Ampoule Filling Machine

Model	AFS-1	AFS-2	AFS-4	AFS-8
No. of Head	Single	Two	Four	Eight
Syringes	One	Double	Four	Eight
Ampoule Sizes	1 ml to 30 ml	1 ml to 30 ml	1 ml to 20 ml	1 ml to 20 ml
Filling Speed	Up to 25 ampoules/minute	Up to 50 ampoules/minute	Up to 100 ampoules/minute	Up to 200 ampoules/minute
Filling Precision	± 1%	± 1%	± 1%	± 1%
Filling Pump	Piston Pump	Piston Pump	Piston Pump	Piston Pump
Burner Gas	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)	LPG & Oxygen (O₂)
Nitrogen Arrangement	Before & After Filling	Before & After Filling	Before & After Filling	Before & After Filling
Number of Fill Nozzles	One	Two	Four	Eight
Number of Nitrogen Nozzles	Two	Four	Eight	Sixteen
Number of Sealing Burners	Two	Four	Eight	Sixteen
Power Required	0.5 H.P.	1 H.P.	1 H.P.	2 H.P.
Power Voltage	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System	230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L	Made from Stainless Steel 316L
Overall Dimension	915mm (L) x 610mm (W) x 965mm (H) approx.	915mm (L) x 760mm (W) x 965mm (H) approx.	1200mm (L) x 1070mm (W) x 965mm (H) approx.	2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Ampoule Filling Machine

Automatic Ampoule Filling Sealing Machine

Laboratory Ampoule Filling Sealing Machine

Closed Ampoule Filling Machine

Open Mouth Ampoule Filling Machine

Onion Skin Ampoule Filling Machine

Single Head Ampoule Filling Machine

Double Head Ampoule Filling Machine

Four Head Ampoule Filling Machine

Six Head Ampoule Filling Machine

Eight Head Ampoule Filling Machine

Applications of Ampoule Filling Machine

Advantages of Glass Ampoule Filling Machine

Precision and Accuracy: Ensures exact dosing, critical for pharmaceuticals to avoid over- or under-dosing.

Sterility: Hermetic sealing and nitrogen flushing protect contents from contaminants, extending shelf life.

Efficiency: High-speed automation reduces labor and increases output.

Durability: Stainless steel construction ensures long-term reliability and easy maintenance.

Flexibility: Handles various ampoule sizes and liquid types (aqueous, viscous, or powders).

Key Features of Glass Ampoule Filling Machine

Functionality: These machines automate the process of filling glass ampoules with liquids (or sometimes powders/pellets) and sealing them, typically using a flame to melt the glass for hermetic sealing. Some models also include nitrogen purging to remove atmospheric air and prevent contamination.

Capacity and Speed: Machines vary in output, ranging from 15 to 36,000 ampoules per hour, depending on the model (e.g., single-head for lab-scale or eight-head for high-speed production). Fill volumes typically range from 0.2 ml to 30 ml.

Design: Built with stainless steel for durability and compliance with cGMP standards. Monoblock designs combine filling and sealing on a single platform for efficiency.

Filling Mechanisms: Common mechanisms include volumetric piston pumps, peristaltic pumps, or servo-driven systems for precise filling. Some feature “no ampoule, no fill” systems to prevent wastage.

Sealing Process: Typically involves pre-heating, gas flushing (oxygen and LPG/propane), and final sealing with a flame. Ampoule necks are centered and rotated during sealing for uniformity.

Additional Features:
- Nitrogen flushing (pre- and post-filling) to ensure sterility.
- PLC systems and HMI for real-time monitoring and error detection.
- Easy changeover for different ampoule sizes (1 ml to 30 ml) with minimal parts.
- Slant travel mechanism to accommodate variations in ampoule neck dimensions, thickness, and ovality.
- Waste tip collection and rejection systems for faulty ampoules.

FAQ for Glass Ampoule Filling Machine

What is the production capacity of the Glass Ampoule Filling Machine?

Our range of machines is designed to meet various production scales. Depending on the model (Single, Two, Four, or Eight-head), the output varies from 25 ampoules per minute (up to 1,500/hour) for lab-scale models to 200 ampoules per minute (up to 12,000/hour) for high-speed industrial models.

Which ampoule sizes can the machine handle?

The machine is highly versatile and can process glass ampoules ranging from 1ml to 30ml. It is designed with a “minimum changeover parts” philosophy, allowing for quick transitions between different sizes (e.g., 1ml to 10ml) with minimal downtime.

How does the machine ensure the sterility and stability of the product?

To ensure the highest pharmaceutical standards, the machine features a Nitrogen Flushing arrangement that can be applied before, during, and after the filling process. This removes atmospheric oxygen, preventing oxidation and maintaining the sterile integrity of the injectable liquid.

What is the filling accuracy of the machine?

Our Glass Ampoule Filling Machines utilize high-precision piston pumps (or optional peristaltic/servo systems) to achieve a filling precision of ± 1%. Additionally, the “No Ampoule – No Filling” system ensures that no liquid is wasted if an ampoule is missing from the station.

Is the machine compliant with international manufacturing standards?

Yes. The machine is a compact model built as per cGMP (Current Good Manufacturing Practice) standards. All contact parts are made from high-quality Stainless Steel 316L, while non-contact parts are made from Stainless Steel 304, ensuring durability and easy sterilization.

Countries We Export to

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

GET A QUOTE!