Biological Indicator Tube Filler Sealer

A Biological Indicator Tube Filler Sealer is a specialized pharmaceutical or laboratory machine designed for automatically filling and sealing small glass tubes or ampoules used as biological indicators (BIs).

These BIs are critical for validating sterilization processes (e.g., in autoclaves, ethylene oxide, or radiation sterilization) in industries like pharmaceuticals, medical devices, and biotechnology. The indicators typically contain a known population of highly resistant bacterial spores in a nutrient broth or on a carrier, housed in thin-walled glass tubes that allow sterilant penetration while protecting the contents.

Biological Indicator Tube Filler Sealer Video

Key Features and Process

• Tube Type — Handles delicate open-mouth glass ampoules/tubes, minimum diameter ~7mm, height ~55mm.

• Operation — Monobloc design (filling and sealing on a single platform); ampoules/tubes are loaded via hopper, advanced through stations for nitrogen purging (to create inert atmosphere), precise volumetric filling, and flame sealing (pull-seal or tip-seal for hermetic closure).

• Capacity — Typically 10–250 units per minute, depending on model.

• Advantages — Ensures sterile, contamination-free production; suitable for biochemical applications, agro-insecticides, veterinary products, or cosmetics in similar glass formats.

• Also Known As — Onion Skin Ampoule Filler Sealer, Crushable Glass Tube Filler, or Biological Indicator Ampoule Filling Machine.

Salient Features of Automatic Ampoule Filler

• Compact model as per cGMP standard.

• Higher production output up to 12000 Ampoules per hour.

• All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.

• Minimum change over parts from 1ml to 10ml ampoule size.

• “No Ampoule – No Filling” system.

• Ampoule neck centering during gas flushing and filling operations.

• Possibility of nitrogen gas flushing before, during and after filling.

• Full accessibility allows easy maintenance.

• Machine equipped with pre-warming station.

• Flow Meters for regulating flames easily.

• Minimum change over time, little maintenance, easy cleaning.

Process Operation of Automatic Tube Filler

The sterilized tube tray directly loaded in to slant hopper of the unit. The Synchronized star wheel delivers tubes, one by one on moving eccentric tube rack in single. During the stoppage of rack sequentially pre-gassing, filling, post gassing, pre heating and final sealing is achieved.

Technical Specification of Tube Filler Sealer

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.