

In today’s fast-paced manufacturing landscape, the crushable tube filler sealer has become an essential piece of equipment for industries requiring accurate, sterile, and efficient packaging of liquid and semi-liquid products. Also known as an ampoule filling and sealing machine or onion skin tube filler, this specialized machinery is designed specifically to handle thin, fragile crushable glass tubes (commonly called onion skin tubes, crushable ampoules, or biological indicator tubes).
These delicate, open-mouth glass tubes are intentionally designed to be easily crushable for single-use applications. Their thin walls allow for quick opening by hand or with simple tools while maintaining product integrity until the moment of use. Because of their precision and sterility, crushable glass tubes are widely used across multiple high-regulation sectors.
The sterilized tube tray directly loaded in to slant hopper of the unit. The Synchronized star wheel delivers tubes, one by one on moving eccentric tube rack in single. During the stoppage of rack sequentially pre-gassing, filling, post gassing, pre heating and final sealing is achieved.
Model | AFS-1 | AFS-2 | AFS-4 | AFS-8 |
No. of Head | Single | Two | Four | Eight |
Syringes | One | Double | Four | Eight |
Ampoule Sizes | 1 ml to 30 ml | 1 ml to 30 ml | 1 ml to 20 ml | 1 ml to 20 ml |
Filling Speed | Up to 25 ampoules/minute | Up to 50 ampoules/minute | Up to 100 ampoules/minute | Up to 200 ampoules/minute |
Filling Precision | ± 1% | ± 1% | ± 1% | ± 1% |
Filling Pump | Piston Pump | Piston Pump | Piston Pump | Piston Pump |
Burner Gas | LPG & Oxygen (O₂) | LPG & Oxygen (O₂) | LPG & Oxygen (O₂) | LPG & Oxygen (O₂) |
Nitrogen Arrangement | Before & After Filling | Before & After Filling | Before & After Filling | Before & After Filling |
Number of Fill Nozzles | One | Two | Four | Eight |
Number of Nitrogen Nozzles | Two | Four | Eight | Sixteen |
Number of Sealing Burners | Two | Four | Eight | Sixteen |
Power Required | 0.5 H.P. | 1 H.P. | 1 H.P. | 2 H.P. |
Power Voltage | 230 Volts, Single Phase, 50 Hertz, 4 Wire System | 230 Volts, Single Phase, 50 Hertz, 4 Wire System | 230 Volts, Single Phase, 50 Hertz, 4 Wire System | 230 Volts, Single Phase, 50 Hertz, 4 Wire System |
Contact Parts | Made from Stainless Steel 316L | Made from Stainless Steel 316L | Made from Stainless Steel 316L | Made from Stainless Steel 316L |
Overall Dimension | 915mm (L) x 610mm (W) x 965mm (H) approx. | 915mm (L) x 760mm (W) x 965mm (H) approx. | 1200mm (L) x 1070mm (W) x 965mm (H) approx. | 2200mm (L) x 1400mm (W) x 1100mm (H) approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
It is specialized machinery designed for accurate, sterile, and efficient filling and sealing of thin, fragile crushable glass tubes (also called onion skin tubes, crushable ampoules, or biological indicator tubes). These open-mouth tubes are used for liquid and semi-liquid products and are intentionally easy to crush for single-use applications while preserving product integrity until use. It is also known as an ampoule filling and sealing machine or onion skin tube filler.
It is widely used in the pharmaceutical, nutraceutical, herbal, Ayurvedic, biotech, cosmetic, and chemical industries for packaging products that require sterile, precise handling of crushable glass tubes.
Sterilized tube trays are loaded into a slant hopper. A synchronized star wheel delivers tubes one by one onto a moving eccentric tube rack. During rack stoppages, the machine sequentially performs pre-gassing, filling, post-gassing, pre-heating, and final sealing.
Key features include a compact cGMP-compliant design, production output up to 12,000 ampoules per hour, a “No Ampoule – No Filling” system, flow meters for easy flame regulation, minimum changeover parts for 1 ml to 10 ml sizes, ampoule neck centering during gas flushing and filling, full accessibility for maintenance, nitrogen gas flushing options (before, during, and after filling), a pre-warming station, SS 316L contact parts and SS 304 non-contact parts, plus easy cleaning and low maintenance.
Models range from AFS-1 (single head, up to 25 ampoules/minute) to AFS-8 (eight heads, up to 200 ampoules/minute). Intermediate models include AFS-2 (up to 50/min) and AFS-4 (up to 100/min). Higher overall output is noted up to 12,000 ampoules per hour depending on configuration.
It handles ampoule sizes from 1 ml to 30 ml (depending on the model; some models limited to 1–20 ml). Filling precision is ±1% across models, using piston pumps.
Yes, nitrogen arrangement is available before and after filling (and optionally during). Sealing uses LPG and oxygen burners, with multiple sealing burners and nitrogen nozzles scaling by model (e.g., up to 16 sealing burners and 16 nitrogen nozzles on the eight-head model). A pre-warming station is also included.
Contact parts are made of high-quality Stainless Steel 316L; non-contact parts use Stainless Steel 304. The design offers full accessibility for easy maintenance, minimum changeover time, little maintenance overall, and easy cleaning. Changeover parts are minimized for size ranges such as 1 ml to 10 ml.
It automates the filling and sealing process to reduce manual labor and human error, delivers high production speeds for greater efficiency, ensures precise and consistent fill volumes to minimize wastage, and provides airtight seals that protect contents from contamination while extending shelf life.
Power typically ranges from 0.5 H.P. (single-head) to 2 H.P. (eight-head) at 230 Volts, single phase, 50 Hz (adjustable to local voltage). Approximate dimensions vary by model—for example, AFS-1 is about 915 mm (L) × 610 mm (W) × 965 mm (H), while AFS-8 is about 2200 mm (L) × 1400 mm (W) × 1100 mm (H). Technical improvements and modifications are reserved by the manufacturer.
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