Injectable Powder Filling Machine

Description

Injectable Powder Filling Machine is a specialized piece of pharmaceutical equipment designed for the precise, sterile filling of dry powders into glass vials or bottles intended for injectable use. These machines ensure accurate dosing, typically ranging from 50 mg to 1,500 mg per vial, while maintaining aseptic conditions to meet cGMP (Current Good Manufacturing Practice) standards. They often integrate filling, rubber stoppering (bunging), and sometimes capping or labeling in a monobloc or linear setup, minimizing contamination risks and supporting high-speed production in cleanroom environments. Injectable Powder Filling Machine are essential in the pharmaceutical, biotech, and nutraceutical industries for packaging cost-sensitive products like penicillin or cephalosporins, where precision is critical to avoid product loss and ensure patient safety.

  • Vial Feeding: Empty sterilized vials are fed via a conveyor or rotary table.

 

  • Powder Agitation: Sterile powder in a hopper is agitated mechanically for consistency.

 

  • Filling: Vials are positioned under the powder wheel; vacuum and air pressure draw and dispense exact doses into each vial.

 

  • Stoppering: Rubber stoppers are automatically picked and pressed into the vials.

 

  • Output: Filled and sealed vials exit for downstream processes like capping, labeling, or inspection.

 

This process operates under controlled humidity and temperature to handle sensitive powders.

If you need details on specific models and pricing, let me know!

Working Principle of Injectable Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

 

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

 

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Injectable Powder Filling Machine

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machines

Applications of Powder Filling Machines

Advantages of Injectable Powder Filling Machine

Superior Sterility Assurance

High Filling Accuracy and Consistency

Hygienic Design and Easy Maintenance

Reduced Wastage and Operational Efficiency

Key Features of Injectable Powder Filling Machine

  • Filling Mechanism: Vacuum-driven or servo-based powder wheels with agitators to maintain uniform powder density and prevent bridging. Accuracy is typically ±2% depending on powder characteristics.

 

  • Stoppering System: Integrated rubber stopper insertion for immediate sealing post-filling.

 

  • Sterility Controls: Inbuilt laminar airflow, no-vial-no-fill sensors, low-air/vacuum stop systems, and optional 100% in-process control (IPC) weighing for quality assurance.

 

  • Construction: Made from stainless steel for durability and easy cleaning/sterilization.

 

  • Safety and Automation: HMI/PLC controls, vial counters, rejection systems, and sensors for powder levels or accumulation to prevent downtime.

FAQ for Injectable Powder Filling Machine

The machine offers a filling accuracy of ±2–3% (depending on powder characteristics, bulk density uniformity, and environmental conditions).

  • APF 12S (Single Powder Wheel): Up to 100 vials/minute
  • APF 12D (Double Powder Wheel): Up to 200 vials/minute Fill range: 50mg to 1200mg (up to 1500mg in single dosing with change parts).

It is ideal for sterile dry powder injectables such as antibiotics, vaccines, and other formulations unstable in liquid form. The machine handles vial sizes from 5ml to 100ml and is widely used in the Pharmaceutical, Biotech, and Nutraceutical industries under controlled sterile environments.

  • Compact cGMP model with SS316L contact parts (easily removable for autoclaving/sterilization).
  • Servo-driven powder wheel and vial transport, vacuum-driven dosing, and tool-less doctor/wiper blade adjustment.
  • Built-in turn tables, integrated rubber stoppering system, and safety features like clutch for vial breakage protection.
  • Options include PLC with HMI, inbuilt Laminar Air Flow (Class 100), IQ/OQ documentation, multiple dosing, and sampling/rejection systems.

  • Superior sterility assurance with minimal contamination risk for injectable powders.
  • High precision dosing with minimal wastage and consistent results.
  • High-speed automated operation suitable for large-scale production.
  • Hygienic design with easy cleaning, fast changeover, and low maintenance.
  • Full regulatory compliance and seamless integration into complete sterile vial filling lines.

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Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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