Injectable Powder Filling Machine (injection powder filler) including Vial dry powder filling machine is cGMP machine designed to fill powder injection vials. Sterile Powder Filler is the monobloc machine which can do filling and stoppering/bunging operations on same platform. All contact parts are made from Stainless Steel 316L or FDA approved materials for cGMP compliance.
Injectable Powder Filling Machine available in Single Powder Wheel and Double Powder Wheel models variants which provide production output ranging from 60 VPM to 200 VPM. Vacuum driven powder wheel with special design to achieve higher filling accuracy. We also offer Vial Cap Sealing Machine and Vial Labeling Machine which makes complete automatic Vial Powder Filling Line.
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.
The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.
The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.
Models | APF 12S | APF 12D |
Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
Fill Volume | 50 mg to 1200 mg | 50 mg to 1200 mg |
Vial Size | 5ml to 100ml | 5ml to 100ml |
Filling Accuracy | ± 2–3% | ± 2–3% |
Power Load | 3.5 H.P. | 4.5 H.P. |
Overall Dimension | 2600mm x 1100mm x 1800mm | 3000mm x 1100mm x 1800mm |
Net Weight | 500 kgs approx. | 700 kgs approx. |
Gross Weight | 750 kgs approx. | 950 kgs approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
The machine typically uses a servo-driven auger screw or vacuum-assisted dosing system to measure and dispense a precise quantity of powder into each vial. Vials are fed through a conveyor, filled in a sterile environment (usually Class 100 / ISO 5 laminar airflow), and then stoppered or sealed. Advanced models feature no-vial-no-fill systems, weight checking, and dust extraction to maintain accuracy and prevent contamination.
Most injectable powder filling machines offer high accuracy of ±1% or better, depending on powder characteristics and vial size. Output capacity typically ranges from 50 to 300 vials per minute (depending on the model and number of filling heads). For exact specifications, check the technical details on our page, as different models support various vial sizes (2ml to 100ml) and production requirements.
Yes, our Injectable Powder Filling Machine is specifically designed for aseptic filling. It features stainless steel contact parts (usually SS 316L), CIP/SIP compatibility, laminar airflow integration, and HEPA filtration to maintain sterility. It meets stringent regulatory requirements for sterile pharmaceutical manufacturing, including FDA, EU GMP, and other international standards.
Key features include servo motor control for precise dosing, no-vial-no-fill and no-stoppers-no-fill systems, easy changeover for different vial sizes, dust-free operation, PLC with HMI for user-friendly operation, and low maintenance design. Benefits include high filling accuracy, reduced product wastage, improved production efficiency, compliance with cGMP norms, and long-term reliability for pharmaceutical companies producing injectable powders.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.
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