Automatic Dry Powder Filling Rubber Stoppering Machine

Q: What is the production capacity and filling accuracy of the machine?

APF 12S (Single Head) : Up to 100 vials/minute APF 12D (Double Head) : Up to 200 vials/minute Fill volume ranges from 50 mg to 10 grams per dose (customizable). Filling accuracy is ±1–3% (typically ±2–3% in single dosing), depending on powder consistency and uniform bulk density.

Q: What are the key features of the Automatic Dry Powder Filling Rubber Stoppering Machine?

Compact cGMP model with SS316 contact parts (easily removable for autoclaving/sterilization) and SS304 frame. “No Vial – No Fill” and “No Stopper – Machine Stop” systems. Built-in Rubber Stoppering Unit with vibratory bowl. Safety clutch, variable AC frequency drive, multiple dosing system, and imported gear motors. Options include PLC/HMI, inbuilt Laminar Air Flow, and IQ/OQ documentation.

Description

Automatic Dry Powder Filling Rubber Stoppering Machine is a specialized pharmaceutical packaging system designed for the precise filling of sterile dry powders into glass vials and immediate sealing with rubber stoppers (bungs). It combines powder dosing via a vacuum-pressure or servo-driven powder wheel with an integrated rubber stoppering unit, ensuring aseptic conditions under laminar flow or isolator technology. This monobloc (single-unit) design minimizes space in cleanrooms, reduces contamination risks, and complies with cGMP, 21 CFR, and FDA standards. It’s ideal for micro-doses of injectable powders, handling vial sizes from 5ml to 30ml with necks of 13mm or 20mm. Unlike general powder fillers, this machine uses time-dosed air/nitrogen flushing for accuracy (±1-2% variance) and features safety interlocks like “no vial/no fill” and “no stopper/machine stop” to prevent errors. It’s commonly used in high-volume sterile production lines.

The machine operates in an intermittent or continuous motion cycle, integrating filling and stoppering in a compact footprint:

Vial Infeed: Sterilized vials enter via an infeed turntable and Delrin conveyor belt, guided by separators to maintain upright orientation.

Powder Filling: Vials index to the powder wheel. Powder from the SS316L hopper is dosed using vacuum to draw it into ports, followed by timed bursts of sterilized compressed air or nitrogen to dispense exact amounts into vials. Pre- and post-gassing options flush oxygen for stability.

Vial Separation: Filled vials are separated by grooves on the conveyor and moved to the stoppering station.

Rubber Stoppering: Sterilized, siliconized rubber stoppers are oriented in a vibratory bowl, stacked in a chute, and picked/placed via vacuum or roller systems. Vials pass under pressing rollers for secure full or half-bunging.

Outfeed: Completed vials exit via an outfeed turntable, ready for capping or labeling. AC frequency drives synchronize speeds, with PLC/HMI for servo models enabling multi-dose adjustments.

Maintenance involves tool-free disassembly of SS316L contact parts for autoclaving. Dust extraction and HEPA filtration ensure sterility.

If you need details on specific models and pricing, let me know!

Salient Features of Automatic Dry Powder Filling Machine

Compact cGMP model.
“No Vial – No Filling” system.
All parts and assemblies coming in contact with powder and rubber stopper are made of S.S.316 and easily removable for mandatory Autoclaving/ Sterilization.
± 1% filling accuracy.
Built-in Rubber Stoppering Unit saves lot of space in the Sterile Area & reduces the length of Laminar Flow.
“No stopper in chute – Machine stop” system.
All motors are provided with appropriate contractors and relays for the protection against any overload or jamming.

All motors are provided with appropriate contractors and relays for the protection against any overload or jamming.
Safety clutch system to avoid Bottle breakage.
Variable A.C. Frequency Drive for speed control.
Multiple Dosing System.
S.S. square pipe frame structure to avoid vibration.
All driving is through High quality imported Gear motor for better machine performance without vibration or leakage of oil of area floor from gear box.
Imported Gear Motor for Main drive, in feed and out feed table.

Working Principle of Automatic Dry Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Automatic Dry Powder Filling Machine

Models	APF 12S	APF 12D
Production Output	Up to 100 vials/minute	Up to 200 vials/minute
Fill Volume	50 mg. to 10grams	50 mg. to 10 grams
Vial Size	5ml to 250ml	5ml to 250ml
Filling Accuracy	± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder	± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder
Power Load	3.5 H. P.	4.5 H. P.
Overall Dimension	2600mm (L) X 1100mm (W) X 1800mm (H) approx.	3000mm (L) X 1100mm (W) X 1800mm (H) approx.
Net Weight	500 kgs. approx.	700 kgs. approx.
Gross Weight	750 kgs. approx.	950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machines

Antibiotic Powder Filling Machine

Injectable Powder Filling Machine

Auger Powder Filling Machine

Bottle Dry Injectable Filling Machine

Automatic Dry Syrup Powder Filling Machine

Dry Syrup Powder Filler Capper

Dry Syrup Powder Filling Machine

Double Head Auger Powder Filling Machine

Applications of Powder Filling Machines

Advantages of Automatic Dry Powder Filling Rubber Stoppering Machine

High Precision and Filling Accuracy

High-Speed Production and Efficiency

Hygienic Design and Easy Maintenance

Regulatory Compliance and Cost-Effectiveness

Key Features of Automatic Dry Powder Filling Rubber Stoppering Machine

Compact cGMP Compliant Design

Monobloc construction that integrates powder filling and rubber stoppering on a single platform. This saves valuable space in the sterile area and reduces the required length of laminar airflow.

High Volumetric Filling Accuracy

Achieves ±2–3% accuracy (depending on powder uniformity). Precise dosing is controlled by adjustable piston depth in the powder wheel ports, with multiple dosing options available. Vacuum-assisted powder wheel with doctor blade ensures consistent fill weights from 50 mg to 10 grams.

Integrated Rubber Stoppering Unit

Built-in vibratory bowl feeder, stopper chute, and pressing rollers for immediate and secure stoppering after filling. This minimizes product exposure and maintains sterility throughout the process.

Hygienic Construction and Easy Maintenance
All contact parts made of SS316L (easily removable for autoclaving/sterilization).
Non-contact parts in SS304.
Individual drives for filling and stoppering to synchronize operations.
Quick-release tooling and tool-less adjustments (e.g., doctor blade).

Advanced Safety and Control Systems
“No Vial, No Fill” system to eliminate powder wastage.
Safety clutch mechanism to prevent vial breakage.
Overload/jamming protection with contactors and relays.
Variable AC Frequency Drive for adjustable speed.
Digital production counter.

FAQ for Automatic Dry Powder Filling Rubber Stoppering Machine

What is an Automatic Dry Powder Filling Rubber Stoppering Machine and how does it work?

An Automatic Dry Powder Filling Rubber Stoppering Machine is a monobloc aseptic system designed for filling sterile dry powders into glass vials and immediately applying rubber stoppers. Powder from the SS316L hopper is metered using a vacuum-assisted powder wheel with pistons. Excess powder is removed by a doctor blade, and the dose is flushed into vials using compressed air or nitrogen. Filled vials then move to the integrated stoppering station where siliconized rubber stoppers are placed and pressed securely. This minimizes exposure and ensures sterility.

What is the production capacity and filling accuracy of the machine?

APF 12S (Single Head): Up to 100 vials/minute
APF 12D (Double Head): Up to 200 vials/minute

Fill volume ranges from 50 mg to 10 grams per dose (customizable). Filling accuracy is ±1–3% (typically ±2–3% in single dosing), depending on powder consistency and uniform bulk density.

What types of products and containers can it handle?

It is ideal for sterile injectable dry powders (e.g., antibiotics) in the Pharmaceutical and Biotech industries. The machine handles vial sizes from 5 ml to 250 ml (commonly 5–30 ml with 13 mm or 20 mm necks) under controlled cleanroom conditions with laminar airflow.

What are the key features of the Automatic Dry Powder Filling Rubber Stoppering Machine?

Compact cGMP model with SS316 contact parts (easily removable for autoclaving/sterilization) and SS304 frame.
“No Vial – No Fill” and “No Stopper – Machine Stop” systems.
Built-in Rubber Stoppering Unit with vibratory bowl.
Safety clutch, variable AC frequency drive, multiple dosing system, and imported gear motors.
Options include PLC/HMI, inbuilt Laminar Air Flow, and IQ/OQ documentation.

What are the main advantages of using an Automatic Dry Powder Filling Rubber Stoppering Machine?

Superior sterility with integrated filling and immediate stoppering in a compact monobloc design.
High precision with minimal wastage and consistent dosing.
Saves space in the sterile area and reduces laminar flow requirements.
Hygienic, easy-to-clean design with fast changeover and low maintenance.
Full regulatory compliance (cGMP, FDA) and high-speed automation for efficient production.

Countries We Export to

Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

GET A QUOTE!