Pharmaceutical Dry Injection Filling Machine

Description

Pharmaceutical Dry Injection Filling Machine is specialized equipment used for the aseptic filling of sterile dry powders, such as antibiotics, vaccines, or other active pharmaceutical ingredients (APIs), into vials, ampoules, or syringes for injectable use. Dry Injection Filling Machine are designed to ensure precise dosing, maintain sterility, and comply with current Good Manufacturing Practices (cGMP) for parenteral drug production. They are critical in pharmaceutical manufacturing for producing dry powder injections that are later reconstituted with a solvent before administration.

  • Powder Loading: Sterile powder is loaded into a hopper with agitators to ensure uniform flow and prevent clumping.

 

  • Container Handling: Pre-sterilized vials or ampoules are fed via a conveyor or rotary wheel into the filling station.

 

  • Dosing: Powder is dispensed using:
    • Volumetric Systems: Adjustable cavities or augers for consistent volume.
    • Gravimetric Systems: Weight-based dosing with real-time feedback.
    • Vacuum-Pressure Systems: For precise filling of fine or sticky powders.

 

  • Stoppering/Capping: Rubber stoppers are placed, and vials are sealed under sterile conditions.

 

  • Inspection: Automated checks for fill accuracy, container integrity, and sterility; defective units are rejected.

 

  • Output: Filled and sealed vials are collected for labeling, packaging, or further processing.

If you need details on specific models and pricing, let me know!

Working Principle of Pharmaceutical Dry Injection Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Pharmaceutical Dry Injection Filling Machine

Models

APF 12S

APF 12D

Production Output

Up to 100 vials/minute

Up to 200 vials/minute

Fill Volume

50 mg. to 10grams

50 mg. to 10 grams

Vial Size

5ml to 250ml

5ml to 250ml

Filling Accuracy

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder

Power Load

3.5 H. P.

4.5 H. P.

Overall Dimension

2600mm (L) X 1100mm (W) X 1800mm (H) approx.

3000mm (L) X 1100mm (W) X 1800mm (H) approx.

Net Weight

500 kgs. approx.

700 kgs. approx.

Gross Weight

750 kgs. approx.

950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Types of Powder Filling Machine

Applications of Powder Filling Machine

Advantages of Pharmaceutical Dry Injection Filling Machine

Superior Sterility and Product Safety

High Filling Accuracy and Minimal Wastage

Increased Efficiency and High-Speed Production

Hygienic Design, Easy Maintenance, and Versatility

Key Features of Pharmaceutical Dry Injection Filling Machine

  • Aseptic Processing: Operates in cleanroom environments with laminar airflow or Restricted Access Barrier Systems to prevent contamination.

 

  • Precision Dosing: Utilizes volumetric, gravimetric, or vacuum-pressure systems to achieve accurate fill weights, often with 100% in-process control.

 

  • Containment: Incorporates isolators or barrier systems to protect operators from potent/toxic powders and prevent cross-contamination.

 

  • High Throughput: Capable of filling 60–450 vials per minute (VPM), depending on the machine’s configuration.

 

  • Integrated Functions: Combines filling, stoppering, and capping in a single monobloc system for efficiency.

 

  • Sterilization: Features in-line sterilization and compatibility with pre-sterilized containers.

 

  • Automation: Includes real-time weight checks, rejection systems for defective vials, and data logging for regulatory compliance.

FAQ for Pharmaceutical Dry Injection Filling Machine

The machine offers a filling accuracy of ±2–3% depending on powder characteristics, bulk density uniformity, and environmental conditions.

  • APF 12S (Single Head): Up to 100 vials per minute
  • APF 12D (Double Head): Up to 200 vials per minute Fill range: 50 mg to 10 grams (with multiple dosing options). It includes a “No Vial, No Fill” system to eliminate powder wastage.

It is ideal for sterile dry powder injectables like antibiotics, vaccines, and other sensitive APIs in the pharmaceutical and biotech industries. The machine handles vial sizes from 5 ml to 250 ml and supports various powder types with consistent flow properties. It operates effectively in Class 100 / ISO 5 cleanroom environments with laminar airflow.

  • Compact cGMP model with SS316L contact parts (easily removable for autoclaving).
  • “No Vial – No Fill” system and safety clutch to prevent vial breakage.
  • Built-in rubber stoppering unit, multiple dosing capability, and variable AC frequency drive.
  • Tool-less doctor blade adjustment and digital production counter.
  • Options for PLC/HMI, in-built laminar airflow, and easy integration into complete sterile lines.

  • Superior sterility assurance and product safety in aseptic processing.
  • High precision dosing with minimal wastage.
  • Increased production efficiency with high-speed automated operation.
  • Hygienic design for easy cleaning, fast changeover, and low maintenance.
  • Regulatory compliance (cGMP, FDA) and extended shelf life for heat-sensitive formulations compared to liquids.

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Partner with Industry Experts

Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.

Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.

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