Pharmaceutical Dry Powder Filling Machine

Pharmaceutical Dry Powder Filling Machine are specialized equipment used in the pharmaceutical industry to accurately and sterilely fill dry powders—such as antibiotics, acyclovir, or lyophilized pellets—into vials, syringes, bottles, or sachets. These machines are essential for producing injectable or oral powder formulations that require stability and cannot be stored in liquid form. They ensure precise dosing, minimize dust and waste, and comply with strict cGMP (Current Good Manufacturing Practice) standards for sterility and contamination prevention.

Pharmaceutical Dry Powder Filling Machine Video

Key Features and Benefits

• Precision and Accuracy: Utilizes auger, volumetric, or vacuum-driven mechanisms to achieve filling accuracy within ±1-2%, critical for dosage-sensitive drugs.

• Sterility: Operates in cleanroom environments with isolator or RABS technology to separate operators from the product.

• Versatility: Handles free-flowing and non-free-flowing powders, granules, or pastes; supports various container sizes and optional stoppering, capping, or sealing.

• Efficiency: High-speed models fill 80-240 vials per minute, reducing manual labor and production time while minimizing powder loss.

• Customization: Modular designs allow integration of weighing modules, servo motors for vibration-free operation, and PLC/HMI controls for easy setup and validation.

How Dry Powder Filling Machines Work

1. Material Loading: Powder is loaded into a hopper, where agitation prevents clumping.

2. Filling: An auger screw or vacuum wheel meters and dispenses the exact powder volume into containers via funnels. Servo-driven systems ensure consistent dosing.

3. Stoppering/Bunging: Rubber stoppers are inserted partially or fully, often for lyophilization compatibility.

4. Capping/Sealing: Aluminum seals or screw caps are applied to prevent contamination and ensure tamper-proof packaging.

5. Inspection and Ejection: Automated checks for fill levels, then filled containers are ejected for downstream processes like labeling.

Salient Features of Dry Powder Filling Machine

• Compact GMP Model.

• Suitable to fill 50mg to 1500mg in single dosing.

• Powder wheel rotation and vial transportation through servo motors.

• Vacuum driven specially designed Powder Wheels.

• All contact parts made of SS316L materials with easy removal system for Autoclaving / Sterilization.

• Filling Accuracy of ± 2% depending upon powder characteristics and environmental conditions.

• Built in Rubber Stoppering System.

• Multiple dosing system with the help of change parts.

• Built in Turn Tables with Separate Drive for speed control of infeed and outfeed of vials.

• Various safety features including Clutch system for Vial Breakage.

• Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.

• IQ/OQ Validation documentation can be provided.

• PLC system with Graphical User Interface can be offered.

• Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.

• Sampling and Rejection system can be provided on demand.

Process Operation of Dry Powder Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air, sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.

The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.

The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.

Technical Specification of Dry Powder Filler Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

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