R&D Ampoule Filler , also known as a Lab Scale Ampoule Filling Machine or Pilot Ampoule Filling and Sealing Machine, is a compact, high-precision pharmaceutical machine designed for research, product development, clinical trials, and small-batch production. It automates the filling and flame sealing of glass ampoules with liquid formulations, including injectable drugs, cosmetics, veterinary medicines, agrochemicals, and other sterile solutions, ensuring accurate dosing, sterility, and contamination-free packaging.
Ideal for pharmaceutical laboratories, pilot plants, and low-volume manufacturing facilities, these machines are engineered to handle ampoules ranging from 1 ml to 25 ml, with production capacities of approximately 10 to 50 ampoules per minute. Their compact design, flexible operation, and quick changeover make them the preferred choice for formulation development, validation batches, and process optimization.
Unlike high-speed commercial ampoule filling machines that produce more than 300 ampoules per minute, R&D ampoule filling and sealing machines focus on precision, ease of operation, and process flexibility. They are typically manufactured using SS 316L stainless steel for superior corrosion resistance and feature autoclavable product-contact parts for easy sterilization. Built to meet stringent pharmaceutical regulations, these machines comply with cGMP (Current Good Manufacturing Practices) and US FDA guidelines, making them suitable for sterile manufacturing environments.
Machine having hopper for storing ampoules. User has to load empty ampoules on this hopper in bulk from where ampoule deliver onto moving rack one by one. In the movement over rack ampoule reaches to the filling station where filling needles fill preset volume of liquid in ampoules. Further ampoules reached to the sealing station where two burner nozzles installed in which first one is preheating nozzle and second is sealing nozzle. Rollers provided for rotation of ampoules, so evenly heating provided on all around the ampoule neck. During rotation of ampoule with nozzle gassing, the glass of ampoule get melt. Sealing clipper installed which do up & down movement above sealing unit. During down movement clipper take off excess melt part of ampoules and drop into waste glass collection box. Duly filled and packed ampoules get collected onto delivery tray of the machine.
This process ensures a fully automated, sterile workflow suitable for R&D trials.
Model | AFS-30 |
Production Output | Up to 25 ampules/minute |
Ampoule Size | 1ml to 30ml |
Filling Accuracy | ± 1% |
Require Gas for Sealing | LPG & Oxygen (O₂) |
Nitrogen Flushing | Pre & Post Nitrogen Flushing Available |
Power Specification | 0.5 H. P. |
Electrical Characteristics | 230 Volts, Single Phase, 50 Hertz |
Contact Parts | Made from Stainless Steel 316L. |
Non-Contact Parts | Made from Stainless Steel 304 |
Overall Dimension | 915mm (L) x 610mm (W) x 965mm (H) approx. |
Net Weight | 150 Kgs. approx. |
Gross Weight | 225 Kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
The R&D Ampoule Filling Machine is engineered to deliver exceptional precision, flexibility, and reliability for laboratory research, pilot production, and small-batch pharmaceutical manufacturing. Its advanced design ensures accurate filling, sterile sealing, and compliance with international quality standards.
Precision Filling System
Equipped with a high-accuracy dosing mechanism to ensure consistent filling volumes with minimal variation, reducing product wastage and improving batch quality.
Filling and Sealing in One Machine
Performs automatic liquid filling and flame sealing in a single integrated process, ensuring hermetically sealed ampoules for maximum product safety and sterility.
Suitable for Multiple Ampoule Sizes
Designed to handle glass ampoules ranging from 1 ml to 25 ml, with quick and easy size changeovers for greater production flexibility.
Compact Laboratory Design
The space-saving construction makes it ideal for pharmaceutical R&D laboratories, pilot plants, cleanrooms, and small-scale manufacturing facilities.
SS 316L Product Contact Parts
All product contact components are manufactured from SS 316L stainless steel, providing excellent corrosion resistance, durability, and compatibility with sterile pharmaceutical products.
Autoclavable Product Contact Components
Product contact parts can be easily removed and sterilized, supporting contamination-free production and simplified cleaning procedures.
User-Friendly Control Panel
Features an intuitive control system for easy operation, parameter adjustment, and process monitoring, reducing operator training time.
Adjustable Filling Volume
Allows quick adjustment of filling volumes to accommodate different formulations and production requirements without extensive machine modifications.
Low Product Loss
Optimized filling technology minimizes spillage and residual product, making the machine suitable for handling high-value pharmaceutical and biotechnology formulations.
Reliable Flame Sealing System
Provides uniform and secure sealing of glass ampoules to maintain sterility, prevent leakage, and extend product shelf life.
Easy Maintenance and Cleaning
Designed with accessible machine components for fast cleaning, routine maintenance, and reduced production downtime.
cGMP and US FDA Compliant Design
Manufactured according to Current Good Manufacturing Practices (cGMP) and US FDA recommendations, making it suitable for regulated pharmaceutical production environments.
Energy-Efficient Operation
Consumes less power while delivering consistent performance, helping reduce operational costs during laboratory and pilot-scale production.
Wide Application Range
Suitable for filling sterile liquid formulations such as injectable medicines, vaccines, cosmetic serums, veterinary products, biotech formulations, herbal extracts, and specialty chemicals.
Scalable Process Development
Supports formulation development, process optimization, and validation before transferring production to high-speed commercial ampoule filling lines, ensuring a smooth scale-up from R&D to full-scale manufacturing.
The machine is suitable for 1 ml to 30 ml glass ampoules. It offers quick and easy size changeovers, making it highly flexible for different formulations during R&D and pilot-scale trials.
The Model AFS-30 delivers an output of up to 25 ampoules per minute. This makes it ideal for low-volume production, validation batches, and process optimization rather than high-speed commercial manufacturing.
It provides excellent filling accuracy of ± 1%, ensuring consistent dosing and minimal product wastage — critical for high-value pharmaceutical and biotech formulations.
Yes. It features SS 316L stainless steel product contact parts that are autoclavable/sterilizable. Optional Class 100 Laminar Air Flow, pre- & post-nitrogen flushing, and cGMP-compliant design help maintain sterility throughout the filling and sealing process.
Empty ampoules are loaded into a hopper and fed to a traveling rack. They undergo nitrogen purging (optional), precise liquid filling via needles, pre-heating, and flame sealing while rotating. A sealing clipper trims excess glass, and filled/sealed ampoules are collected on a delivery tray. The entire process is automated for consistency and sterility.
The machine requires LPG and Oxygen (O₂) for flame sealing. Pre- and post-nitrogen flushing is also available to displace air and protect oxygen-sensitive products.
It is widely used in:
Yes. Options include variable speed via frequency drive, PLC with GUI, safety guards, laminar airflow, different filling mechanisms, IQ/OQ documentation, and voltage adjustments to match local power requirements. Contact the manufacturer for specific customization needs.
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Connect with our engineering team to discuss your specific production requirements. We provide customized, cGMP-compliant machinery solutions designed to optimize your manufacturing facility and maximize output.
Adinath International manufactures high-precision vial powder filling machines and complete packaging lines, providing reliable, hygienic, and efficient solutions for global pharmaceutical industries.
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